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LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer

  • Authors:
    • Shuang Han
    • De‑Zhan Li
    • Mei‑Fang Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei 434020, P.R. China, Department of Anesthesiology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei 434020, P.R. China, Department of Clinical Laboratory, Center for Laboratory Medicine, Hainan Women and Children's Medical Center, Haikou, Hainan 570206, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4673-4681
    |
    Published online on: October 25, 2019
       https://doi.org/10.3892/etm.2019.8135
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Abstract

Ovarian cancer (OC) is one of the most fatal types of gynecological malignancy. Certain long non‑coding RNAs (lncRNA) have been reported to have crucial roles in cancer progression. Zinc finger nuclear transcription factor, X‑box binding 1‑type containing 1 antisense RNA 1 (ZFAS1) is a novel regulator lncRNA in various cancer types. The expression pattern of most lncRNAs, including ZFAS1, in OC remains to be determined. In the present study, it was demonstrated that ZFAS1 was overexpressed in OC vs. normal cell lines. However, ZFAS1 was downregulated in OC compared with normal samples in the GEPIA dataset. Furthermore, OC samples of higher stages (stage III/IV) had higher levels of ZFAS1 compared with those in early‑stage OC (stage I/II) samples. Of note, higher ZFAS1 expression was associated with shorter overall survival time and disease‑free survival time of OC patients. Protein‑protein interaction networks of proteins co‑expressed with ZFAS1 in OC were constructed. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of genes co‑expressed with ZFAS1 indicated that ZFAS1 is associated with translation, mRNA splicing, cell‑cell adhesion, DNA repair, protein sumoylation, positive regulation of GTPase activity and DNA replication. The present study may provide novel clues to validate ZFAS1 as a biomarker in OC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 671:7–30. 2017. View Article : Google Scholar

2 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ma J and Xue M: LINK-A lncRNA promotes migration and invasion of ovarian carcinoma cells by activating TGF-β pathway. Biosci Rep. 38(pii): BSR201809362018. View Article : Google Scholar : PubMed/NCBI

4 

Shu C, Yan D, Mo Y, Gu J, Shah N and He J: Long noncoding RNA lncARSR promotes epithelial ovarian cancer cell proliferation and invasion by association with HuR and miR-200 family. Am J Cancer Res. 86:981–992. 2018.

5 

Nie F, Yu X, Huang M, Wang Y, Xie M, Ma H, Wang Z, De W and Sun M: Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. Oncotarget. 824:38227–38238. 2017.

6 

Fang C, Zan J, Yue B, Liu C, He C and Yan D: Long non-coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression. J Gastroenterol Hepatol. 326:1204–1211. 2017. View Article : Google Scholar

7 

Xia B, Hou Y, Chen H, Yang S, Liu T, Lin M and Lou G: Long non-coding RNA ZFAS1 interacts with miR-150-5p to regulate Sp1 expression and ovarian cancer cell malignancy. Oncotarget. 8:19534–19546. 2017.PubMed/NCBI

8 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42((Database Issue)): D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. eLife. 4:e050052015. View Article : Google Scholar

11 

Garcia DM, Baek D, Shin C, Bell GW, Grimson A and Bartel DP: Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol. 18:1139–1146. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Franceschini A, Lin J, von Mering C and Jensen LJ: SVD-phy: Improved prediction of protein functional associations through singular value decomposition of phylogenetic profiles. Bioinformatics. 32:1085–1087. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 254:402–408. 2001. View Article : Google Scholar

16 

Wang JS, Liu QH, Cheng XH, Zhang WY and Jin YC: The long noncoding RNA ZFAS1 facilitates bladder cancer tumorigenesis by sponging miR-329. Bio Pharm. 103:174–181. 2018. View Article : Google Scholar

17 

Huang Y, Hu Y, Jin Z and Shen Z: LncRNA snaR upregulates GRB2-associated binding protein 2 and promotes proliferation of ovarian carcinoma cells. Biochem Biophys Res Commun. 503:2028–2032. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH and Zhao Y: LncRNA PCGEM1 induces ovarian carcinoma tumorigenesis and progression through RhoA pathway. Cell Physiol Biochem. 474:1578–1588. 2018. View Article : Google Scholar

19 

Jin Y, Feng SJ, Qiu S, Shao N and Zheng JH: LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. Eur Rev Med Pharmacol Sci. 2114:3176–3184. 2017.

20 

Wang W and Xing C: Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer. Pathol Res Pract. 2128:690–695. 2016. View Article : Google Scholar

21 

Song W, Tian C, Zhang RJ, Zou SB and Wang K: Meta-analysis of the prognostic value of lncRNA ZFAS1 in patients with solid tumors. Oncotarget. 852:90301–90307. 2017.

22 

Chen X, Li J, Li CL and Lu X: Long non-coding RAN ZFAS1 promotes nasopharyngeal carcinoma through activation of Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2211:3423–3429. 2018.

23 

Chen X, Yang C, Xie S and Cheung E: Long non-coding RNA GAS5 and ZFAS1 are prognostic markers involved in translation targeted by miR-940 in prostate cancer. Oncotarget. 91:1048–1062. 2018.

24 

Li N, Sun ZH, Fang M, Xin JY and Wan CY: Long non-coding RNA ZFAS1 sponges miR-486 to promote osteosarcoma cells progression and metastasis in vitro and vivo. Oncotarget. 861:104160–104170. 2017.

25 

Xie S, Ge Q, Wang X, Sun X and Kang Y: Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer. Cell Cycle. 172:154–161. 2018. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Han S, Li DZ and Xiao MF: LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer. Exp Ther Med 18: 4673-4681, 2019.
APA
Han, S., Li, D., & Xiao, M. (2019). LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer. Experimental and Therapeutic Medicine, 18, 4673-4681. https://doi.org/10.3892/etm.2019.8135
MLA
Han, S., Li, D., Xiao, M."LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer". Experimental and Therapeutic Medicine 18.6 (2019): 4673-4681.
Chicago
Han, S., Li, D., Xiao, M."LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4673-4681. https://doi.org/10.3892/etm.2019.8135
Copy and paste a formatted citation
x
Spandidos Publications style
Han S, Li DZ and Xiao MF: LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer. Exp Ther Med 18: 4673-4681, 2019.
APA
Han, S., Li, D., & Xiao, M. (2019). LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer. Experimental and Therapeutic Medicine, 18, 4673-4681. https://doi.org/10.3892/etm.2019.8135
MLA
Han, S., Li, D., Xiao, M."LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer". Experimental and Therapeutic Medicine 18.6 (2019): 4673-4681.
Chicago
Han, S., Li, D., Xiao, M."LncRNA ZFAS1 serves as a prognostic biomarker to predict the survival of patients with ovarian cancer". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4673-4681. https://doi.org/10.3892/etm.2019.8135
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