Open Access

Dexmedetomidine enhances hypoxia‑induced cancer cell progression

  • Authors:
    • Hua Yan Chen
    • Geng Hua Li
    • Guo Cheng Tan
    • Hua Liang
    • Xiao Hong Lai
    • Qiong Huang
    • Ji Ying Zhong
  • View Affiliations

  • Published online on: October 25, 2019     https://doi.org/10.3892/etm.2019.8136
  • Pages: 4820-4828
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dexmedetomidine (DEX) is widely used in perioperative settings for analgesia and sedation; however, little is known about its effects on the hypoxia‑induced progression of tumor cells. In the present study, the effects of DEX on hypoxia‑induced growth and metastasis of lung cancer cells and colorectal cancer cells was examined. A549 cells and HCT116 cells were treated with normoxia, hypoxia, co‑treatment of hypoxia and DEX, and atipamezole (an α2 adrenoceptor antagonist) for 4 h. The proliferation rate of cells was determined by MTT assays. Cell metastatic potential was evaluated by Transwell assays. Survivin and hypoxia inducible factor (HIF)‑1α were detected by western blotting. Matrix metalloproteinase (MMP)‑2 and MMP‑9 were measured using reverse transcription‑quantitative PCR. It was demonstrated that hypoxia treatment promoted the proliferation and may promote the metastasis of the two cancer cell lines. DEX substantially contributed to the survival and aggressiveness of the two cancer cell lines following hypoxia. Furthermore, DEX upregulated the expression of survivin, MMP‑2, MMP‑9 and HIF‑1α in the two cancer cell lines in response to hypoxia. Finally, the effects of DEX on the hypoxia‑induced growth and metastatic potential of cancer cells were reversed by atipamezole. Collectively, DEX enhances the hypoxia‑induced progression of lung cancer cells and colorectal cancer cells by regulating HIF‑1α signaling, which may be associated with the α2 adrenoceptor pathway.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Chen, H.Y., Li, G.H., Tan, G.C., Liang, H., Lai, X.H., Huang, Q., & Zhong, J.Y. (2019). Dexmedetomidine enhances hypoxia‑induced cancer cell progression. Experimental and Therapeutic Medicine, 18, 4820-4828. https://doi.org/10.3892/etm.2019.8136
MLA
Chen, H. Y., Li, G. H., Tan, G. C., Liang, H., Lai, X. H., Huang, Q., Zhong, J. Y."Dexmedetomidine enhances hypoxia‑induced cancer cell progression". Experimental and Therapeutic Medicine 18.6 (2019): 4820-4828.
Chicago
Chen, H. Y., Li, G. H., Tan, G. C., Liang, H., Lai, X. H., Huang, Q., Zhong, J. Y."Dexmedetomidine enhances hypoxia‑induced cancer cell progression". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4820-4828. https://doi.org/10.3892/etm.2019.8136