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Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases

  • Authors:
    • Marinela Bostan
    • Georgiana Gabriela Petrică‑Matei
    • Gabriela Ion
    • Nicoleta Radu
    • Mirela Mihăilă
    • Răzvan Hainăroşie
    • Lorelei Irina Braşoveanu
    • Viviana Roman
    • Carolina Constantin
    • Monica Teodora Neagu
  • View Affiliations / Copyright

    Affiliations: ‘Stefan S. Nicolau’ Institute of Virology, Center of Immunology, 030304 Bucharest, Romania, Department of Cytogenetics, Personal Genetics ‑ Medical Genetics Center, 010987 Bucharest, Romania, Department of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Βucharest, Romania, ‘Prof. Dr. Dorin Hociotă’ Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania, Department of Immunology, ‘Victor Babeș’ National Institute of Pathology, 050096 Bucharest, Romania
    Copyright: © Bostan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5041-5051
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    Published online on: October 25, 2019
       https://doi.org/10.3892/etm.2019.8139
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Abstract

The extracellular signal‑regulated kinases (ERKs) are key transducers of the extracellular signals into intracellular responses and represent major molecular players in tumorigenesis. The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin‑CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA‑PJ49) and the involvement of ERK1/2 and/or p53 activation in this process. Data have shown that the CisPt effect is potentiated by CRM. CRM induced an increase of p53 protein phosphorylation in both cell lines. CisPt decreased p53 protein phosphorylation in FaDu cells, but increased it in PE/CA‑PJ49 cells. Data showed that the constitutive expression of activated ERK1/2 protein‑kinase was different in the two analyzed tumor cell lines. ERK1/2 activation status was essential for both cell processes, proliferation and apoptosis induced by CisPt and/or CRM treatment on squamous cell carcinoma cells. Our data suggest that p53 phosphorylation in the apoptotic process induced by CRM treatment might require the involvement of ERK1/2. In this regard the CisPt treatment suggested that p53 phosphorylation is ERK1/2 independent in FaDu cells having a p53 gene deletion and ERK1/2 dependent in PE/CA‑PJ49 cells having a p53 gene amplification. Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation‑ERK1/2 activation‑dependent in the apoptosis induced by combined treatments (CisPt and CRM). The use of CRM as adjuvant could increase the efficiency of chemotherapy by modulating cellular activation processes of ERK1/2 signaling pathways. In conclusion, the particular mode of intervention by which ERK1/2 might influence cell proliferation and/or apoptosis processes depends on the type of therapeutic agent, the cells' particularities, and the activation status of the ERK1/2.
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View References

1 

Ursu RG, Danciu M, Spiridon IA, Ridder R, Rehm S, Maffini F, McKay-Chopin S, Carreira C, Lucas E, Costan VV, et al: Role of mucosal high-risk human papillomavirus types in head and neck cancers in Romania. PLoS One. 13:e01996632018. View Article : Google Scholar : PubMed/NCBI

2 

Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R and Ferlay J: Cancer Incidence in Five Continents VolX. International Agency for Research on Cancer; Lyon: 2014

3 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Kumar M, Nanavati R, Modi TG and Dobariya C: Oral cancer: Etiology and risk factors: A review. J Cancer Res Ther. 12:458–463. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Vigneswaran N and Williams MD: Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin North Am. 26:123–141. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, et al EORTC 24971/TAX 323 Study Group, : Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 357:1695–1704. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Jimenez L, Jayakar SK, Ow TJ and Segall JE: Mechanisms of invasion in head and neck cancer. Arch Pathol Lab Med. 139:1334–1348. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Voiculescu VM, Caruntu C, Solomon I, Lupu M, Ilie MA, Boda D, Constantin C and Neagu M: Squamous cell carcinoma: Biomarkers and potential therapeutic targetsHuman Skin Cancers - Pathways, Mechanisms, Targets and Treatments. Blumenberg M: IntechOpen; London: pp. 135–159. 2018

9 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Zhai TT, van Dijk LV, Huang BT, Lin ZX, Ribeiro CO, Brouwer CL, Oosting SF, Halmos GB, Witjes MJH, Langendijk JA, et al: Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters. Radiother Oncol. 124:256–262. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Lupu M, Caruntu A, Caruntu C, Boda D, Moraru L, Voiculescu V and Bastian A: Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. Mol Clin Oncol. 8:640–646. 2018.PubMed/NCBI

12 

Boda D, Docea AO, Calina D, Ilie MA, Caruntu C, Zurac S, Neagu M, Constantin C, Branisteanu DE, Voiculescu V, et al: Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review). Int J Oncol. 52:637–655. 2018.PubMed/NCBI

13 

Hassan M, Watari H, AbuAlmaaty A, Ohba Y and Sakuragi N: Apoptosis and molecular targeting therapy in cancer. BioMed Res Int. 2014:1508452014. View Article : Google Scholar : PubMed/NCBI

14 

Neagu M, Constantin C, Popescu ID, Zipeto D, Tzanakakis G, Nikitovic D, Fenga C, Stratakis CA, Spandidos DA and Tsatsakis AM: Inflammation and metabolism in cancer cell - mitochondria key player. Front Oncol. 9:3482019. View Article : Google Scholar : PubMed/NCBI

15 

Cagnol S and Chambard JC: ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence. FEBS J. 277:2–21. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Huang J, Zhang J, Shi C, Liu L and Wei Y: Survival, recurrence and toxicity of HNSCC in comparison of a radiotherapy combination with cisplatin versus cetuximab: A meta-analysis. BMC Cancer. 16:6892016. View Article : Google Scholar : PubMed/NCBI

17 

Neagu M, Caruntu C, Constantin C, Boda D, Zurac S, Spandidos DA and Tsatsakis AM: Chemically induced skin carcinogenesis: Updates in experimental models (Review). Oncol Rep. 35:2516–2528. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Kass JI, Moskowitz HS and Grandis JR: Oncogenomics/Proteomics of Head and Neck Cancers. Head and Neck CancerMultimodality Management. 2nd. Springer International Publishing; New York, NY: pp. 101–114. 2016

19 

Chen L and Tweddle DA: p53, SKP2, DKK3 as MYCN target genes and their potential therapeutic significance. Cancer Molecular Targets and Therapeutic. Front Oncol. 2:1732012. View Article : Google Scholar : PubMed/NCBI

20 

Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013. View Article : Google Scholar

21 

Powell E, Piwnica-Worms D and Piwnica-Worms H: Contribution of p53 to metastasis. Cancer Discov. 4:405–414. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Samatar AA and Poulikakos PI: Targeting RAS-ERK signalling in cancer: Promises and challenges. Nat Rev Drug Discov. 13:928–942. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Solomon I, Voiculescu VM, Caruntu C, Lupu M, Popa A, Ilie MA, Albulescu R, Caruntu A, Tanase C, Constantin C, et al: Neuroendocrine factors and head and neck squamous cell carcinoma: An affair to remember. Dis Markers. 2018:97878312018. View Article : Google Scholar : PubMed/NCBI

24 

Yang SH, Sharrocks AD and Whitmarsh AJ: MAP kinase signalling cascades and transcriptional regulation. Gene. 513:1–13. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lupu M, Caruntu A, Caruntu C, Papagheorghe LM, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, et al: Neuroendocrine factors: The missing link in non melanoma skin cancer (Review). Oncol Rep. 38:1327–1340. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Burotto M, Chiou VL, Lee JM and Kohn EC: The MAPK pathway across different malignancies: A new perspective. Cancer. 120:3446–3456. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Urosevic J, Nebreda AR and Gomis RR: MAPK signaling control of colon cancer metastasis. Cell Cycle. 13:2641–2642. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Tanase CP, Neagu M and Albulescu R: Key signaling molecules in pituitary tumors. Expert Rev Mol Diagn. 9:859–877. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Yang M and Huang CZ: Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer. World J Gastroenterol. 21:11673–11679. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Peng Q, Deng Z, Pan H, Gu L, Liu O and Tang Z: Mitogen-activated protein kinase signaling pathway in oral cancer. Oncol Lett. 15:1379–1388. 2018.PubMed/NCBI

31 

Kumari R, Chouhan S, Singh S, Chhipa RR, Ajay AK and Bhat MK: Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. J Biosci. 42:31–41. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Wang J, Luo L, Wang D, Guo B, Li J, Yang Z and Tang D: Combination adjuvant chemotherapy with targeted drugs for treatment of colorectal cancer: A network meta-analysis. J Cell Biochem. 119:1521–1537. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Bailon-Moscoso N, Cevallos-Solorzano G, Romero-Benavides JC and Orellana MI: Natural compounds as modulators of cell cycle arrest: Application for anticancer chemotherapies. Curr Genomics. 18:106–131. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Seca AM and Pinto DC: Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. Int J Mol Sci. 19:E2632018. View Article : Google Scholar : PubMed/NCBI

35 

Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Tan BK, Kumar AP and Sethi G: The multifaceted role of curcumin in cancer prevention and treatment. Molecules. 20:2728–2769. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Miao Y, Zhao S, Gao Y, Wang R, Wu Q, Wu H and Luo T: Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling. Brain Res Bull. 121:9–15. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Shi D, Xu Y, Du X, Chen X, Zhang X, Lou J, Li M and Zhuo J: Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways. Mol Med Rep. 12:8223–8228. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Patel PB, Thakkar VR and Patel JS: Cellular effect of curcumin and citral combination on breast cancer cells: Induction of apoptosis and cell cycle arrest. J Breast Cancer. 18:225–234. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Neagu M, Constantin C, Tanase C and Boda D: Patented biomarker panels in early detection of cancer. Recent Pat Biomark. 1:10–24. 2011. View Article : Google Scholar

40 

Chen XY, Cai HZ, Wang XY, Chen QY, Yang H, Chen YJ and Tang YP: Application of the ERK signaling pathway inhibitor PD98059 in long-term in vivo experiments. Genet Mol Res. 14:18325–33. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Barltrop JA, Owen TC, Cory AH and Cory JG: 5-(3-carboxymethoxyphenyl)-2-(4,5-dimenthylthiazoly)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans as cell-viability indicators. Bioorg Med Chem Lett. 1:611–614. 1991. View Article : Google Scholar

42 

Petrică-Matei GG, Iordache F, Hainăroşie R and Bostan M: Characterization of the tumor cells from human head and neck cancer. Rom J Morphol Embryol. 57 (Suppl 2):791–799. 2016.PubMed/NCBI

43 

Hirshberg A, Yarom N, Amariglio N, Yahalom R, Adam I, Stanchescu R, Ben-Dov I, Taicher S, Rechavi G and Trakhtenbrot L: Detection of non-diploid cells in premalignant and malignant oral lesions using combined morphological and FISH analysis - a new method for early detection of suspicious oral lesions. Cancer Lett. 253:282–290. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Salido M, Tusquets I, Corominas JM, Suarez M, Espinet B, Corzo C, Bellet M, Fabregat X, Serrano S and Solé F: Genetic alterations of chromosome 17 in human breast carcinoma studied by fluorescence in situ hybridization and molecular DNA techniques. Breast Cancer Res. 7:267–273. 2005. View Article : Google Scholar

45 

Sunahori K, Nagpal K, Hedrich CM, Mizui M, Fitzgerald LM and Tsokos GC: The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients. J Biol Chem. 288:21936–21944. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Bundscherer A, Malsy M, Lange R, Hofmann P, Metterlein T, Graf BM and Gruber M: Cell harvesting method influences results of apoptosis analysis by Annexin V staining. Anticancer Res. 33:3201–3204. 2013.PubMed/NCBI

47 

Zedan W, Mourad MI, El-Aziz SMA, Salamaa NM and Shalaby AA: Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma. Diagn Pathol. 10:22015. View Article : Google Scholar : PubMed/NCBI

48 

Jin C, Jin Y, Wennerberg J, Akervall J, Dictor M and Mertens F: Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck. Cancer Genet Cytogenet. 132:85–96. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Papavasileiou D, Tosios K, Christopoulos P, Goutas N and Vlachodimitropoulos D: Her-2 immunohistochemical expression in oral squamous cell carcinomas is associated with polysomy of chromosome 17, not Her-2 amplification. Head Neck Pathol. 3:263–270. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Wang L, Liu T, Nishioka M, Aguirre RL, Win SS and Okada N: Activation of ERK1/2 and cyclin D1 expression in oral tongue squamous cell carcinomas: Relationship between clinicopathological appearances and cell proliferation. Oral Oncol. 42:625–631. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Chambard JC, Lefloch R, Pouysségur J and Lenormand P: ERK implication in cell cycle regulation. Biochim Biophys Acta. 1773:1299–1310. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Aguzzi A, Maggioni D, Nicolini G, Tredici G, Gaini RM and Garavello W: MAP kinase modulation in squamous cell carcinoma of the oral cavity. Anticancer Res. 29:303–308. 2009.PubMed/NCBI

53 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Engelbrecht AM, Gebhardt S and Louw L: Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis. Cancer Lett. 235:93–99. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH and Holland EC: Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell. 18:619–629. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Hasima N and Aggarwal BB: Cancer-linked targets modulated by curcumin. Int J Biochem Mol Biol. 3:328–351. 2012.PubMed/NCBI

57 

Baharuddin P, Satar N, Fakiruddin KS, Zakaria N, Lim MN, Yusoff NM, Zakaria Z and Yahaya BH: Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines. Oncol Rep. 35:13–25. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Borges GÁ, Rêgo DF, Assad DX, Coletta RD, De Luca Canto G and Guerra EN: In vivo and in vitro effects of curcumin on head and neck carcinoma: A systematic review. J Oral Pathol Med. 46:3–20. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bostan M, Petrică‑Matei GG, Ion G, Radu N, Mihăilă M, Hainăroşie R, Braşoveanu LI, Roman V, Constantin C, Neagu MT, Neagu MT, et al: Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Exp Ther Med 18: 5041-5051, 2019.
APA
Bostan, M., Petrică‑Matei, G.G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R. ... Neagu, M.T. (2019). Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Experimental and Therapeutic Medicine, 18, 5041-5051. https://doi.org/10.3892/etm.2019.8139
MLA
Bostan, M., Petrică‑Matei, G. G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R., Braşoveanu, L. I., Roman, V., Constantin, C., Neagu, M. T."Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases". Experimental and Therapeutic Medicine 18.6 (2019): 5041-5051.
Chicago
Bostan, M., Petrică‑Matei, G. G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R., Braşoveanu, L. I., Roman, V., Constantin, C., Neagu, M. T."Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5041-5051. https://doi.org/10.3892/etm.2019.8139
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Spandidos Publications style
Bostan M, Petrică‑Matei GG, Ion G, Radu N, Mihăilă M, Hainăroşie R, Braşoveanu LI, Roman V, Constantin C, Neagu MT, Neagu MT, et al: Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Exp Ther Med 18: 5041-5051, 2019.
APA
Bostan, M., Petrică‑Matei, G.G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R. ... Neagu, M.T. (2019). Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Experimental and Therapeutic Medicine, 18, 5041-5051. https://doi.org/10.3892/etm.2019.8139
MLA
Bostan, M., Petrică‑Matei, G. G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R., Braşoveanu, L. I., Roman, V., Constantin, C., Neagu, M. T."Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases". Experimental and Therapeutic Medicine 18.6 (2019): 5041-5051.
Chicago
Bostan, M., Petrică‑Matei, G. G., Ion, G., Radu, N., Mihăilă, M., Hainăroşie, R., Braşoveanu, L. I., Roman, V., Constantin, C., Neagu, M. T."Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5041-5051. https://doi.org/10.3892/etm.2019.8139
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