Antidepressant effect of the interaction of fluoxetine with granisetron

Costescu,Mihnea; Paunescu,Horia; Coman,Oana  Andreia; Coman,Laurențiu; Fulga,Ion

doi:10.3892/etm.2019.8141

December-2019 Volume 18 Issue 6

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December-2019 Volume 18 Issue 6

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Article

Antidepressant effect of the interaction of fluoxetine with granisetron

Authors:
- Mihnea Costescu
- Horia Paunescu
- Oana Andreia Coman
- Laurențiu Coman
- Ion Fulga
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Affiliations: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, UMF Carol Davila, 050474 Bucharest, Romania, Department of Physiology, Faculty of Pharmacy, UMF Carol Davila, 050474 Bucharest, Romania
Pages: 5108-5111
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Published online on: October 29, 2019

https://doi.org/10.3892/etm.2019.8141
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Abstract

Selective serotonin reuptake inhibitors (SSRIs) may produce digestive side effects such as nausea and vomiting, diarrhoea and decreased appetite. These side effects are determined by the increase in serotonin availability at 5‑HT3 receptors. Granisetron, a serotonin 5‑HT3 receptor antagonist, is expected to antagonize the digestive adverse effects of serotonin reuptake inhibitors, but the question is to what extent granisetron influences the antidepressant effect of these substances. The aim of this study was to determine the dose of fluoxetine that has an antidepressant effect in the Porsolt test, and the interaction between fluoxetine and granisetron with respect to the antidepressant effect in this test. In experiment 1, fluoxetine was antidepressant only at 20 mg/kg body weight (bw). In experiment 2, granisetron 1 mg/kg bw had a statistically significant antidepressant effect vs. control. Fluoxetine 20 mg/kg bw associated with a small dose of granisetron (0.1 mg/kg bw) produced a significant antidepressant effect vs. control. This shows that low doses of granisetron associated to fluoxetine might produce a significant antidepressant effect, suggesting a potentiation between these two drugs used in sub‑effective antidepressant doses. In conclusion, in our experimental conditions, we can assume that granisetron in low doses could be used to combat intestinal transit disorders produced by SSRI antidepressants. These low doses are preferred, because they increase the antidepressant effect of these SSRIs.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Antidepressant effect of the interaction of fluoxetine with granisetron

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