Antidepressant effect of the interaction of fluoxetine with granisetron

  • Authors:
    • Mihnea Costescu
    • Horia Paunescu
    • Oana Andreia Coman
    • Laurențiu Coman
    • Ion Fulga
  • View Affiliations

  • Published online on: October 29, 2019     https://doi.org/10.3892/etm.2019.8141
  • Pages: 5108-5111
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Abstract

Selective serotonin reuptake inhibitors (SSRIs) may produce digestive side effects such as nausea and vomiting, diarrhoea and decreased appetite. These side effects are determined by the increase in serotonin availability at 5‑HT3 receptors. Granisetron, a serotonin 5‑HT3 receptor antagonist, is expected to antagonize the digestive adverse effects of serotonin reuptake inhibitors, but the question is to what extent granisetron influences the antidepressant effect of these substances. The aim of this study was to determine the dose of fluoxetine that has an antidepressant effect in the Porsolt test, and the interaction between fluoxetine and granisetron with respect to the antidepressant effect in this test. In experiment 1, fluoxetine was antidepressant only at 20 mg/kg body weight (bw). In experiment 2, granisetron 1 mg/kg bw had a statistically significant antidepressant effect vs. control. Fluoxetine 20 mg/kg bw associated with a small dose of granisetron (0.1 mg/kg bw) produced a significant antidepressant effect vs. control. This shows that low doses of granisetron associated to fluoxetine might produce a significant antidepressant effect, suggesting a potentiation between these two drugs used in sub‑effective antidepressant doses. In conclusion, in our experimental conditions, we can assume that granisetron in low doses could be used to combat intestinal transit disorders produced by SSRI antidepressants. These low doses are preferred, because they increase the antidepressant effect of these SSRIs.
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December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Costescu, M., Paunescu, H., Coman, O.A., Coman, L., & Fulga, I. (2019). Antidepressant effect of the interaction of fluoxetine with granisetron. Experimental and Therapeutic Medicine, 18, 5108-5111. https://doi.org/10.3892/etm.2019.8141
MLA
Costescu, M., Paunescu, H., Coman, O. A., Coman, L., Fulga, I."Antidepressant effect of the interaction of fluoxetine with granisetron". Experimental and Therapeutic Medicine 18.6 (2019): 5108-5111.
Chicago
Costescu, M., Paunescu, H., Coman, O. A., Coman, L., Fulga, I."Antidepressant effect of the interaction of fluoxetine with granisetron". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5108-5111. https://doi.org/10.3892/etm.2019.8141