Open Access

Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis

  • Authors:
    • Daniela Păcurar
    • Irina Dijmărescu
    • Adrian Dijmărescu
    • Mirela Pavelescu
    • Mihai Andronie
    • Cristina Becheanu
  • View Affiliations

  • Published online on: October 30, 2019     https://doi.org/10.3892/etm.2019.8144
  • Pages: 5101-5104
  • Copyright: © Păcurar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic viral hepatitis has been incriminated for inducing autoimmune events, but it is a known fact that interferon‑based therapies also promote autoimmunity. We conducted an observational prospective study which included 114 pediatric patients with chronic viral hepatitis B and C. The patients were divided in 2 groups, the first group consisted of treatment‑naive patients; the second group included patients who had received interferon‑based therapy. We aimed to determine whether the ones who received treatment are more predisposed to developing autoimmune manifestations when compared to those naive. Fifty percent of the study group was found to have serological autoimmune phenomenon. Our research shows that the occurrence of the autoimmune phenomenon is delayed when the patient is treated with interferon‑based regimens when compared to naive patients. Hence, even though interferon treatment has been reported to promote autoimmunity, the viruses themselves are more likely to induce the appearance of autoimmune markers over time in patients who do not receive treatment.
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December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Păcurar, D., Dijmărescu, I., Dijmărescu, A., Pavelescu, M., Andronie, M., & Becheanu, C. (2019). Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis. Experimental and Therapeutic Medicine, 18, 5101-5104. https://doi.org/10.3892/etm.2019.8144
MLA
Păcurar, D., Dijmărescu, I., Dijmărescu, A., Pavelescu, M., Andronie, M., Becheanu, C."Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis". Experimental and Therapeutic Medicine 18.6 (2019): 5101-5104.
Chicago
Păcurar, D., Dijmărescu, I., Dijmărescu, A., Pavelescu, M., Andronie, M., Becheanu, C."Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5101-5104. https://doi.org/10.3892/etm.2019.8144