Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis

Păcurar,Daniela; Dijmărescu,Irina; Dijmărescu,Adrian; Pavelescu,Mirela; Andronie,Mihai; Becheanu,Cristina

doi:10.3892/etm.2019.8144

December-2019 Volume 18 Issue 6

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December-2019 Volume 18 Issue 6

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Article Open Access

Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis

Authors:
- Daniela Păcurar
- Irina Dijmărescu
- Adrian Dijmărescu
- Mirela Pavelescu
- Mihai Andronie
- Cristina Becheanu
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Affiliations: Department of Pediatrics, ‘Grigore Alexandrescu’ Emergency Children's Hospital, 011743 Bucharest, Romania, Department of Radiology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Economic Sciences, Faculty of Economic Sciences, Spiru Haret University, 030045 Bucharest, Romania

Copyright: © Păcurar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 5101-5104
|
Published online on: October 30, 2019

https://doi.org/10.3892/etm.2019.8144
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Abstract

Chronic viral hepatitis has been incriminated for inducing autoimmune events, but it is a known fact that interferon‑based therapies also promote autoimmunity. We conducted an observational prospective study which included 114 pediatric patients with chronic viral hepatitis B and C. The patients were divided in 2 groups, the first group consisted of treatment‑naive patients; the second group included patients who had received interferon‑based therapy. We aimed to determine whether the ones who received treatment are more predisposed to developing autoimmune manifestations when compared to those naive. Fifty percent of the study group was found to have serological autoimmune phenomenon. Our research shows that the occurrence of the autoimmune phenomenon is delayed when the patient is treated with interferon‑based regimens when compared to naive patients. Hence, even though interferon treatment has been reported to promote autoimmunity, the viruses themselves are more likely to induce the appearance of autoimmune markers over time in patients who do not receive treatment.

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1	Hsieh MY, Dai CY, Lee LP, Huang JF, Chuang WL, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, et al: Antinuclear antibody titer and treatment response to peginterferon plus ribavirin for chronic hepatitis C patients. Kaohsiung J Med Sci. 28:86–93. 2012. View Article : Google Scholar : PubMed/NCBI
2	Muratori P, Muratori L, Verucchi G, Attard L, Bianchi FB and Lenzi M: Non-organ-specific autoantibodies in children with chronic hepatitis C: Clinical significance and impact on interferon treatment. Clin Infect Dis. 37:1320–1326. 2003. View Article : Google Scholar : PubMed/NCBI
3	Kansu A, Kuloğlu Z, Demirçeken F and Girgin N: Autoantibodies in children with chronic hepatitis B infection and the influence of interferon alpha. Turk J Gastroenterol. 15:213–218. 2004.PubMed/NCBI
4	Lapierre P and Lamarre A: Regulatory T cells in autoimmune and viral chronic hepatitis. J Immunol Res. 2015:4797032015. View Article : Google Scholar : PubMed/NCBI
5	Piconese S, Cammarata I and Barnaba V: Viral hepatitis, inflammation, and cancer: A lesson for autoimmunity. J Autoimmun. 95:58–68. 2018. View Article : Google Scholar : PubMed/NCBI
6	Sharif K, Watad A, Coplan L, Lichtbroun B, Krosser A, Lichtbroun M, Bragazzi NL, Amital H, Afek A and Shoenfeld Y: The role of stress in the mosaic of autoimmunity: An overlooked association. Autoimmun Rev. 17:967–983. 2018. View Article : Google Scholar : PubMed/NCBI
7	Grigore O, Mihailescu AI, Solomon I, Boda D and Caruntu C: Role of stress in modulation of skin neurogenic inflammation. Exp Ther Med. 17:997–1003. 2019.PubMed/NCBI
8	Viganò M, Grossi G, Loglio A and Lampertico P: Treatment of hepatitis B: Is there still a role for interferon? Liver Int. 38 (Suppl 1):79–83. 2018. View Article : Google Scholar : PubMed/NCBI
9	Zhu S, Zhang H, Dong Y, Wang L, Xu Z, Liu W, Gan Y, Tang H, Chen D, Wang F, et al: Antiviral therapy in hepatitis B virus-infected children with immune-tolerant characteristics: A pilot open-label randomized study. J Hepatol. 68:1123–1128. 2018. View Article : Google Scholar : PubMed/NCBI
10	Orságová I, RoŽnovský L, Petroušová L, Konečná M, Kabieszová L, Martinek J, Kloudová A and Pavliska L: Investigation of autoimmunity markers during interferon alpha therapy of chronic hepatitis B and C - twenty years of experience. Klin Mikrobiol Infekc Lek. 22:61–67. 2016.(In Czech). PubMed/NCBI
11	Pop TL, Stefănescu A, Samaşca G and Miu N: Clinical significance of the antinuclear antibodies in chronic viral hepatitis B in children. Clin Lab. 60:931–939. 2014. View Article : Google Scholar : PubMed/NCBI
12	Vajro P and Veropalumbo C: Treating children with HBeAg-positive chronic hepatitis B: No small accomplishment. Dig Liver Dis. 46:1064–1065. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Autoimmune phenomena in treated and naive pediatric patients with chronic viral hepatitis

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Abstract

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