Open Access

Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study

  • Authors:
    • Zhizhong He
    • Zhifan Yuan
    • Limei Liang
    • Xinx In Xie
    • Jianjun Yuan
    • Wenxu He
    • Junjun Chen
    • Yongpei Kuang
  • View Affiliations

  • Published online on: October 31, 2019     https://doi.org/10.3892/etm.2019.8151
  • Pages: 4765-4773
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multiparametric MRI fusion with transrectal ultrasound (mpMRI/TRUS)‑guided biopsy has the sensitivity of mpMRI with the practicality of TRUS, but males with no cancerous lesion(s) detected on mpMRI have a considerable remaining risk of cancer. Endorectal power Doppler ultrasound improves the sensitivity of grayscale ultrasound‑guided biopsies. The objective of the present study was to evaluate the beneficial effect of endorectal power Doppler/grayscale ultrasound‑guided biopsy over that of mpMRI/TRUS‑guided biopsy for decision‑making regarding prostatectomy in males with a high risk of prostate cancer. Data regarding endorectal power Doppler/grayscale ultrasound‑guided biopsies and mpMRI/TRUS‑guided biopsies of 1,094 males with elevated specific prostate antigen, were included. Radical prostatectomy was performed in males aged <70 years with Gleason scores ≥3+4 in any one of the biopsy reports. The histopathological data of the surgical specimen of 776 males were included in the analysis. Compared to the histopathology of the surgical specimen, endorectal power Doppler/grayscale ultrasound‑guided biopsies had a lower sensitivity (0.930 vs. 1.000; P<0.0001) but mpMRI/TRUS‑guided biopsies had the same sensitivity (0.990 vs. 1.000; P=0.02). The accuracy of mpMRI/TRUS‑guided biopsies was higher than that of endorectal power Doppler/grayscale ultrasound‑guided biopsies (0.944 vs. 0.783). On mpMRI, lesions of 105 subjects (10%) with a Likert scale score of <3 were identified. Among them, 14 subjects (2%) had Gleason scores of ≥3+4 as determined by endorectal power Doppler/grayscale ultrasound‑guided biopsies. In addition, 20 (2%) false‑positive lesions compared to the histopathological analysis of the surgical specimen were identified from mpMRI/TRUS‑guided biopsies. In conclusion, mpMRI/TRUS‑guided biopsy was indicated to have a moderate performance and endorectal power Doppler/grayscale ultrasound‑guided biopsy had a scant performance for decision‑making regarding prostatectomy.
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December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
He, Z., Yuan, Z., Liang, L., Xie, X.I., Yuan, J., He, W. ... Kuang, Y. (2019). Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study. Experimental and Therapeutic Medicine, 18, 4765-4773. https://doi.org/10.3892/etm.2019.8151
MLA
He, Z., Yuan, Z., Liang, L., Xie, X. I., Yuan, J., He, W., Chen, J., Kuang, Y."Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study". Experimental and Therapeutic Medicine 18.6 (2019): 4765-4773.
Chicago
He, Z., Yuan, Z., Liang, L., Xie, X. I., Yuan, J., He, W., Chen, J., Kuang, Y."Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4765-4773. https://doi.org/10.3892/etm.2019.8151