Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection

  • Authors:
    • Susu He
    • Dongqing Lv
    • Youzu Xu
    • Xiaomai Wu
    • Ling Lin
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Taizhou Hospital of Wenzhou Medical University, Linhai, Zhejiang 317000, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 160-164
    |
    Published online on: November 7, 2019
       https://doi.org/10.3892/etm.2019.8172
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A case report of coinfection with Talaromyces marneffei (T. marneffei) and Cryptococcus neoformans (C. neoformans) is presented in a 57‑year‑old woman with hemolytic anemia who received dexamethasone for 8 years. To the best of our knowledge, this patient was successfully treated with voriconazole. This is the first case of T. marneffei and C. neoformans coinfection in a HIV‑negative host. Clinicians should be aware of concomitant infection with T. marneffei and other pathogens in immunocompromised hosts. The current case report highlights the importance of clinician awareness of concurrent infections with T. marneffei and other pathogens in immunosuppressed patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

DiSalvo AF, Fickling AM and Ajello L: Infection caused by Penicillium marneffei: Description of first natural infection in man. Am J Clin Pathol. 60:259–263. 1973. View Article : Google Scholar : PubMed/NCBI

2 

Vanittanakom N, Cooper CR Jr, Fisher MC and Sirisanthana T: Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev. 19:95–110. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Ustianowski AP, Sieu TP and Day JN: Penicillium marneffei Infection in HIV. Curr Opin Infect Dis. 21:31–36. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE and Sirisanthana T: Disseminated Penicillium marneffei infection in Southeast Asia. Lancet. 344:110–113. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Kawila R, Chaiwarith R and Supparatpinyo K: Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in northern Thailand: A retrospective study. BMC Infect Dis. 13:4642013. View Article : Google Scholar : PubMed/NCBI

6 

Zheng J, Gui X, Cao Q, Yang R, Yan Y, Deng L and Lio J: A clinical study of acquired immunodeficiency syndrome associated Penicillium mameffei infection from a non-endemic area in China. PLOS One. 10:e01303762015. View Article : Google Scholar : PubMed/NCBI

7 

Le T, Hong Chau TT, Kim Cuc NT, Si Lam P, Manh Sieu TP, Shikuma CM and Day JN: AIDS-Associated Cryptococcus neoformans and Penicillium marneffei Coinfection: A therapeutic dilemma in resource-limited settings. Clin Infect Dis. 51:e65–e68. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Larsson M, Nguyen LH, Wertheim HF, Dao TT, Taylor W, Horby P, Nguyen TV, Nguyen MH, Le T and Nguyen KV: Clinical characteristics and outcome of Penicillium mameffei infection among HIV-infected patients in northern Vietnam. AIDS Res Ther. 9:242012. View Article : Google Scholar : PubMed/NCBI

9 

Hatakeyama S, Yamashita T, Sakai T and Kamei K: Case Report: Disseminated Talaromyces (Penicillium) marneffei and mycobacterium tuberculosis coinfection in a japanese patient with acquired immunodeficiency syndrome. Am J Trop Med Hyg. 97:38–41. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Nascimento E, Vitali LH, Kress MRVZ and Martinez R: Cryptococcus neoformans and C. Gattii isolates from both HIV-infected and uninfected patients: Antifungal susceptibility and outcome of cryptococcal disease. Rev Inst Med Trop Sao Paulo. 59:e492017. View Article : Google Scholar : PubMed/NCBI

11 

Lin JN, Lin HH, Lai CH, Wang JL and Yu TJ: Renal transplant recipient infected with Penicillium marneffei. Lancet Infect Dis. 10:1382010. View Article : Google Scholar : PubMed/NCBI

12 

Chong YB, Tan LP, Robinson S, Lim SK, Ng KP, Keng TC and Kamarulzaman A: Penicilliosis in lupus patients presenting with unresolved fever: A report of 2 cases and literature review. Trop Biomed. 29:270–276. 2012.PubMed/NCBI

13 

Lee PP, Chan KW, Lee TL, Ho MH, Chen XY, Li CH, Chu KM, Zeng HS and Lau YL: Penicilliosis in children without HIV infection-are they immunodeficient? Clin Infect Dis. 54:e8–e19. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Chitasombat M and Supparatpinyo K: Penicillium marneffei infection in immunocompromised host. Curr Fungal Infect Rep. 7:44–50. 2013. View Article : Google Scholar

15 

Wong SY and Wong KF: Penicillium mameffei infection in AIDS. Pathol Res Int. 2011:7642932011. View Article : Google Scholar

16 

Ma T, Chen R, Li X, Lu C and Xi L: The in vitro fungicidal activity of human macrophages against Penicillium marneffei is suppressed by dexamethasone. Microb Pathog. 86:26–31. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, et al: Adult-onset immunodeficiency in thailand and taiwan. N Engl J Med. 367:725–734. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lee PP, Mao H, Yang W, Chan KW, Ho MH, Lee TL, Chan JF, Woo PC, Tu W and Lau YL: Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations. J Allergy Clin Immunol. 133:894–896.e5. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Vanittanakom N and Sirisanthana T: Penicillium marneffei infection in patients infected with human immunodeficiency virus. Curr Top Med Mycol. 8:35–42. 1997.PubMed/NCBI

20 

Sirisanthana T, Supparatpinyo K, Perriens J and Nelson KE: Amphotericin B and itraconazole for treatment of disseminated Penicillium marneffei infection in human immunodeficiency virus-infected patients. Clin Infect Dis. 26:1107–1110. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Wang JL, Hung CC, Chang SC, Chueh SC and La MK: Disseminated Penicillium marneffei infection in a renal-transplant recipient successfully treated with liposomal amphotericin B. Transplantation. 76:1136–1137. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Walsh TJ, Pappas P, Winston DJ, Lazarus HM, Petersen F, Raffalli J, Yanovich S, Stiff P, Greenberg R, Donowitz G, et al: Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever. N Engl J Med. 346:225–234. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Zmeili OS and Soubani AO: Pulmonary aspergillosis: A clinical update. QJM. 100:317–334. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ouyang Y, Cai S, Liang H and Cao C: Administration of voriconazole in disseminated talaromyces (Penicillium) Marneffei Infection: A Retrospective Study. Mycopathologia. 182:569–575. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Perfect JR, Marr KA, Walsh TJ, Greenberg RN, DuPont B, de la Torre-Cisneros J, Just-Nübling G, Schlamm HT, Lutsar I, Espinel-Ingroff A and Johnson E: Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis. 36:1122–1131. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Alves IA, Staudt KJ, Silva CM, Lock GA, Dalla Costa T and de Araujo BV: Influence of experimental cryptococcal meningitis in wistar rats on voriconazole brain penetration assessed by microdialysis. Antimicrob Agents Chemother. 61(pii): e00321–e00417. 2017.PubMed/NCBI

27 

Herkert PF, Hagen F, de Oliveira Salvador GL, Gomes RR, Ferreira MS, Vicente VA, Muro MD, Pinheiro RL, Meis JF and Queiroz-Telles F: Molecular characterisation and antifungal susceptibility of clinical Cryptococcus deuterogattii (AFLP6/VGII) isolates from Southern Brazil. Eur J Clin Microbiol Infect Dis. 35:1803–1810. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He S, Lv D, Xu Y, Wu X and Lin L: Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection. Exp Ther Med 19: 160-164, 2020.
APA
He, S., Lv, D., Xu, Y., Wu, X., & Lin, L. (2020). Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection. Experimental and Therapeutic Medicine, 19, 160-164. https://doi.org/10.3892/etm.2019.8172
MLA
He, S., Lv, D., Xu, Y., Wu, X., Lin, L."Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection". Experimental and Therapeutic Medicine 19.1 (2020): 160-164.
Chicago
He, S., Lv, D., Xu, Y., Wu, X., Lin, L."Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection". Experimental and Therapeutic Medicine 19, no. 1 (2020): 160-164. https://doi.org/10.3892/etm.2019.8172
Copy and paste a formatted citation
x
Spandidos Publications style
He S, Lv D, Xu Y, Wu X and Lin L: Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection. Exp Ther Med 19: 160-164, 2020.
APA
He, S., Lv, D., Xu, Y., Wu, X., & Lin, L. (2020). Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection. Experimental and Therapeutic Medicine, 19, 160-164. https://doi.org/10.3892/etm.2019.8172
MLA
He, S., Lv, D., Xu, Y., Wu, X., Lin, L."Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection". Experimental and Therapeutic Medicine 19.1 (2020): 160-164.
Chicago
He, S., Lv, D., Xu, Y., Wu, X., Lin, L."Concurrent infection with Talaromyces marneffei and Cryptococcus neoformans in a patient without HIV infection". Experimental and Therapeutic Medicine 19, no. 1 (2020): 160-164. https://doi.org/10.3892/etm.2019.8172
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team