miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2

Zhao,Qiang; Liu,Chengkui; Cui,Qing; Luan,Xuerong; Wang,Qingfeng; Zhou,Chengfu

doi:10.3892/etm.2019.8175

January-2020 Volume 19 Issue 1

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January-2020 Volume 19 Issue 1

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Article Open Access

miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2

Authors:
- Qiang Zhao
- Chengkui Liu
- Qing Cui
- Xuerong Luan
- Qingfeng Wang
- Chengfu Zhou
View Affiliations / Copyright

Affiliations: Department of Gastrointestinal Surgery, Zibo Central Hospital, Zibo, Shandong 255000, P.R. China

Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 79-84
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Published online on: November 8, 2019

https://doi.org/10.3892/etm.2019.8175
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Abstract

microRNA‑190b (miR‑190b) is abnormally expressed in multiple types of cancer, however, its role in colorectal cancer (CRC) is largely unknown. In the present study, it was demonstrated that miR‑190b expression was upregulated in CRC cell lines compared with the normal epithelial colon cell line. Knockdown of miR‑190b decreased proliferation, colony formation and invasion, and increased apoptosis of CRC cells. Furthermore, forkhead box protein P2 (FOXP2) was predicted as a target of miR‑190b and further validated by luciferase activity reporter assay and western blotting. Rescue experiments showed that knockdown of FOXP2 reversed the inhibitory effects of miR‑190b inhibitor on the behavior of the CRC cell lines. Taken together, the present study demonstrated the oncogenic role of miR‑190b in CRC through regulation of FOXP2 expression.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2

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