Open Access

miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2

  • Authors:
    • Qiang Zhao
    • Chengkui Liu
    • Qing Cui
    • Xuerong Luan
    • Qingfeng Wang
    • Chengfu Zhou
  • View Affiliations

  • Published online on: November 8, 2019     https://doi.org/10.3892/etm.2019.8175
  • Pages: 79-84
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

microRNA‑190b (miR‑190b) is abnormally expressed in multiple types of cancer, however, its role in colorectal cancer (CRC) is largely unknown. In the present study, it was demonstrated that miR‑190b expression was upregulated in CRC cell lines compared with the normal epithelial colon cell line. Knockdown of miR‑190b decreased proliferation, colony formation and invasion, and increased apoptosis of CRC cells. Furthermore, forkhead box protein P2 (FOXP2) was predicted as a target of miR‑190b and further validated by luciferase activity reporter assay and western blotting. Rescue experiments showed that knockdown of FOXP2 reversed the inhibitory effects of miR‑190b inhibitor on the behavior of the CRC cell lines. Taken together, the present study demonstrated the oncogenic role of miR‑190b in CRC through regulation of FOXP2 expression.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao Q, Liu C, Cui Q, Luan X, Wang Q and Zhou C: miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2. Exp Ther Med 19: 79-84, 2020
APA
Zhao, Q., Liu, C., Cui, Q., Luan, X., Wang, Q., & Zhou, C. (2020). miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2. Experimental and Therapeutic Medicine, 19, 79-84. https://doi.org/10.3892/etm.2019.8175
MLA
Zhao, Q., Liu, C., Cui, Q., Luan, X., Wang, Q., Zhou, C."miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2". Experimental and Therapeutic Medicine 19.1 (2020): 79-84.
Chicago
Zhao, Q., Liu, C., Cui, Q., Luan, X., Wang, Q., Zhou, C."miR‑190b promotes colorectal cancer progression through targeting forkhead box protein P2". Experimental and Therapeutic Medicine 19, no. 1 (2020): 79-84. https://doi.org/10.3892/etm.2019.8175