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Article

A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics

  • Authors:
    • Min Wu
    • Qingxiong Yu
    • Bowen Gao
    • Lingling Sheng
    • Qingfeng Li
    • Feng Xie
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China
  • Pages: 313-318
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/etm.2019.8198
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Abstract

Giant congenital melanocytic nevi (GCMN) place a heavy psychological burden on patients due to their poor cosmetic appearance. The histopathological characteristics of GCMN have remained largely elusive. The present study investigated the histopathological characteristics of GCMN in association with their clinical appearance. A total of 98 patients diagnosed with GCMN were included in the present study and their clinical features were collected from their records. Lesion specimens were obtained and stained for histopathological analysis. Regarding the microscopic appearance of GCMN, nevi cells in the whole dermis exhibited different patterns than those in healthy tissues. Most GCMN cases featured a sub‑epidermal non‑involvement zone, which implies an early occurrence in embryo development. Darker nevi exhibited a higher density of infiltrated nevi cells and more pigment deposition; this appears to induce a poor skin texture. Chemical peeling and laser therapy only partly removes pigment particles and nevi cells in the upper portion of the dermis. The clinical features of GCMN are associated with the histopathological characteristics, and non‑surgical therapy cannot remove the nevus cells in the deep dermis.
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Copy and paste a formatted citation
Spandidos Publications style
Wu M, Yu Q, Gao B, Sheng L, Li Q and Xie F: A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics. Exp Ther Med 19: 313-318, 2020.
APA
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., & Xie, F. (2020). A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics. Experimental and Therapeutic Medicine, 19, 313-318. https://doi.org/10.3892/etm.2019.8198
MLA
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., Xie, F."A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics". Experimental and Therapeutic Medicine 19.1 (2020): 313-318.
Chicago
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., Xie, F."A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics". Experimental and Therapeutic Medicine 19, no. 1 (2020): 313-318. https://doi.org/10.3892/etm.2019.8198
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Yu Q, Gao B, Sheng L, Li Q and Xie F: A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics. Exp Ther Med 19: 313-318, 2020.
APA
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., & Xie, F. (2020). A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics. Experimental and Therapeutic Medicine, 19, 313-318. https://doi.org/10.3892/etm.2019.8198
MLA
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., Xie, F."A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics". Experimental and Therapeutic Medicine 19.1 (2020): 313-318.
Chicago
Wu, M., Yu, Q., Gao, B., Sheng, L., Li, Q., Xie, F."A large‑scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics". Experimental and Therapeutic Medicine 19, no. 1 (2020): 313-318. https://doi.org/10.3892/etm.2019.8198
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