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Article

Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children

  • Authors:
    • Yi Lu
    • Meiqin Di
    • Chan Li
    • Mengmeng Chen
    • Kaiming Yuan
    • Wangning Shangguan
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
  • Pages: 353-358
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/etm.2019.8199
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Abstract

Pulse oximetry and measurement of regional cerebral oxygen saturation (rcSO2) are used to monitor peripheral and cerebral oxygenation, respectively. However, the response of rcSO2 and pulse oxygen saturation (SpO2) to hypoxia in preschool children has not been previously assessed. A total of 36 preschool patients who had undergone a tonsillectomy [age, 4‑6 years, American Society of Anesthesiologists grade I or II] were screened and prospectively enrolled in the present study. Hemodynamics, including rcSO2, SpO2, non‑invasive blood pressure, heart rate, electrocardiogram and capnography, were continuously monitored throughout the study. Following pre‑oxygenation, pressure‑controlled ventilation with 100% oxygen was administered through a mask with a flow rate of 6 l/min, under total intravenous anesthesia, and the end‑tidal carbon dioxide partial pressure was maintained between 30 and 40 mmHg. Tracheal intubation was then performed and ventilation was paused until SpO2 decreased to 90% or rcSO2 decreased by >10% of the baseline level. The duration from pausing of mechanical ventilation to the start of the rcSO2 decline was shorter than that of SpO2 (80.2±23.6 sec vs. 124.4±20.5 sec; P<0.001). Subsequent to the recovery of ventilation, the duration from the starting point to the increasing point of the baseline of rcSO2 was longer than that of SpO2 (84.8±24.3 sec vs. 15.2±6.8 sec; P<0.001). From the point where mechanical ventilation was paused to when rcSO2/SpO2 began to decrease, the rcSO2 and SpO2 values decreased and a significant correlation of them was observed (Pearson's correlation coefficient=0.317; P=0.027). From the time‑point where mechanical ventilation was recovered to the time‑point where rcSO2 or SpO2 began to increase, rcSO2 and SpO2 values decreased and a significant correlation of them was observed (Spearman's correlation coefficient=0.489; P=0.006). From the baseline to the minimum value, compared with the SpO2, the rcSO2 declined at a decreased rate (9.7±0.5% vs. 5.3±2.7%; P<0.001). The present clinical trial was registered at http://www.chictr.org.cn on 14th March 2016 (registration no. ChiCTR‑OOC‑16008095).
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Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Di M, Li C, Chen M, Yuan K and Shangguan W: Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children. Exp Ther Med 19: 353-358, 2020.
APA
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., & Shangguan, W. (2020). Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children. Experimental and Therapeutic Medicine, 19, 353-358. https://doi.org/10.3892/etm.2019.8199
MLA
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., Shangguan, W."Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children". Experimental and Therapeutic Medicine 19.1 (2020): 353-358.
Chicago
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., Shangguan, W."Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children". Experimental and Therapeutic Medicine 19, no. 1 (2020): 353-358. https://doi.org/10.3892/etm.2019.8199
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Di M, Li C, Chen M, Yuan K and Shangguan W: Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children. Exp Ther Med 19: 353-358, 2020.
APA
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., & Shangguan, W. (2020). Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children. Experimental and Therapeutic Medicine, 19, 353-358. https://doi.org/10.3892/etm.2019.8199
MLA
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., Shangguan, W."Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children". Experimental and Therapeutic Medicine 19.1 (2020): 353-358.
Chicago
Lu, Y., Di, M., Li, C., Chen, M., Yuan, K., Shangguan, W."Comparing the response of pulse oximetry and regional cerebral oxygen saturation to hypoxia in preschool children". Experimental and Therapeutic Medicine 19, no. 1 (2020): 353-358. https://doi.org/10.3892/etm.2019.8199
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