Open Access

A novel CpG‑based signature for survival prediction of lung adenocarcinoma patients

  • Authors:
    • Rongjiong Zheng
    • Haiqi Xu
    • Wenjie Mao
    • Zhennan Du
    • Mingming Wang
    • Meiling Hu
    • Xiaolong Gu
  • View Affiliations

  • Published online on: November 15, 2019     https://doi.org/10.3892/etm.2019.8200
  • Pages: 280-286
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung adenocarcinoma (LACA) is the leading cause of cancer‑associated death worldwide. The present study intended to identify DNA methylation patterns that may serve as diagnostic and prognostic biomarkers for LACA. Data on DNA methylation and the survival data of the patients of LACA were obtained from The Cancer Genome Atlas. Kaplan‑Meier curves and receiver operating characteristic curve analysis were utilized to build diagnostic and prognostic models. A total of 13 CpG sites were identified and validated as the optimal diagnostic and prognostic signature for overall survival. It was concluded that the CpG‑based signature is a reliable predictor for the diagnosis and prognosis of patients with LACA.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng R, Xu H, Mao W, Du Z, Wang M, Hu M and Gu X: A novel CpG‑based signature for survival prediction of lung adenocarcinoma patients. Exp Ther Med 19: 280-286, 2020
APA
Zheng, R., Xu, H., Mao, W., Du, Z., Wang, M., Hu, M., & Gu, X. (2020). A novel CpG‑based signature for survival prediction of lung adenocarcinoma patients. Experimental and Therapeutic Medicine, 19, 280-286. https://doi.org/10.3892/etm.2019.8200
MLA
Zheng, R., Xu, H., Mao, W., Du, Z., Wang, M., Hu, M., Gu, X."A novel CpG‑based signature for survival prediction of lung adenocarcinoma patients". Experimental and Therapeutic Medicine 19.1 (2020): 280-286.
Chicago
Zheng, R., Xu, H., Mao, W., Du, Z., Wang, M., Hu, M., Gu, X."A novel CpG‑based signature for survival prediction of lung adenocarcinoma patients". Experimental and Therapeutic Medicine 19, no. 1 (2020): 280-286. https://doi.org/10.3892/etm.2019.8200