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Article Open Access

STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway

  • Authors:
    • Feida Wang
    • Zhenye Guo
    • Yinpeng Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Osteopathy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 722-728
    |
    Published online on: December 2, 2019
       https://doi.org/10.3892/etm.2019.8268
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Abstract

Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator‑mediated OA dysfunction modules, and carried out in‑depth analysis in order to examine the disease development process. Differential expression analysis, co‑expression analysis and enrichment analysis were combined to screen genes related to disease progression. Subsequently, key regulatory factors in the process of OA were identified based on the pivotal regulators that may manipulate important parts of the module subnetwork. A total of 16 OA dysfunction modules were obtained, involving the aggregation of 3,239 module genes. Then, enrichment analysis showed that module genes were significantly involved in apoptosis, inflammation‑related functions and signaling pathways. Finally, we revealed a series of regulators, including 842 ncRNA (miR‑132‑3p, miR‑130a‑3p and miR‑590‑3p), 59 transcription factors (NFKB1, RELA and STAT3). We consider that STAT3 is the core transcription factor and promotes the development of OA through the signal of NF‑κB. Overall, our results provide biologists and pharmacists with a new way of thinking to reveal the disease process of OA, and provide a wider range of candidate targets for follow‑up research.
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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Guo Z and Yuan Y: STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway. Exp Ther Med 19: 722-728, 2020.
APA
Wang, F., Guo, Z., & Yuan, Y. (2020). STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 19, 722-728. https://doi.org/10.3892/etm.2019.8268
MLA
Wang, F., Guo, Z., Yuan, Y."STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway". Experimental and Therapeutic Medicine 19.1 (2020): 722-728.
Chicago
Wang, F., Guo, Z., Yuan, Y."STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway". Experimental and Therapeutic Medicine 19, no. 1 (2020): 722-728. https://doi.org/10.3892/etm.2019.8268
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Guo Z and Yuan Y: STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway. Exp Ther Med 19: 722-728, 2020.
APA
Wang, F., Guo, Z., & Yuan, Y. (2020). STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 19, 722-728. https://doi.org/10.3892/etm.2019.8268
MLA
Wang, F., Guo, Z., Yuan, Y."STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway". Experimental and Therapeutic Medicine 19.1 (2020): 722-728.
Chicago
Wang, F., Guo, Z., Yuan, Y."STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway". Experimental and Therapeutic Medicine 19, no. 1 (2020): 722-728. https://doi.org/10.3892/etm.2019.8268
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