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Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma

  • Authors:
    • Yan Wang
    • Mingzhu Liu
    • Shenglan Chen
    • Qin Wu
  • View Affiliations / Copyright

    Affiliations: College of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu 224000, P.R. China, Department of Dermatology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210014, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1065-1071
    |
    Published online on: December 9, 2019
       https://doi.org/10.3892/etm.2019.8303
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Abstract

Avicularin (AL), quercetin‑3‑α‑L‑arabinofuranoside, has various pharmacological properties such as anticancer and anti‑infective effects. However, the potential molecular mechanism via which AL exerts its anticancer activity is not fully understood. Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer, where metastasis has resulted in in effective clinical treatments. The aim of the present in vitro study was to investigate the anticancer effects and underlying mechanism of AL on human CSCC. The present results suggested that AL dose‑dependently inhibited SCC13 cell viability and induced apoptosis. In addition, the present results suggested that AL induced apoptosis via repression of the mitogen‑activated protein kinase kinase (MEK)/NF‑κB signal pathway, thereby affecting the expression of apoptosis‑related genes. Bax expression level was increased, while Bcl‑2 expression level was decreased in SCC13 cells following AL treatment. In addition, the MEK/NF‑κB signaling pathway‑related genes p‑MEK and phosphorylated‑p65 were also decreased. The present results suggested that AL treatment increased the expression level of E‑cadherin, but decreased the expression levels of N‑cadherin, matrix metalloproteinase (MMP)‑9 and vimentin in SCC13 cells. Collectively, the present results suggested that AL may have an anti‑CSCC effect by inhibiting cell viability, inducing apoptosis and inhibiting epithelial‑mesenchymal transition (EMT) of CSCC cells. The mechanism of these anti‑CSCC effects was suggested to be via the regulation of apoptosis‑related genes and EMT‑related genes, and the inhibition of the MEK/NF‑κB signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu M, Chen S and Wu Q: Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma. Exp Ther Med 19: 1065-1071, 2020.
APA
Wang, Y., Liu, M., Chen, S., & Wu, Q. (2020). Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma. Experimental and Therapeutic Medicine, 19, 1065-1071. https://doi.org/10.3892/etm.2019.8303
MLA
Wang, Y., Liu, M., Chen, S., Wu, Q."Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma". Experimental and Therapeutic Medicine 19.2 (2020): 1065-1071.
Chicago
Wang, Y., Liu, M., Chen, S., Wu, Q."Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1065-1071. https://doi.org/10.3892/etm.2019.8303
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu M, Chen S and Wu Q: Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma. Exp Ther Med 19: 1065-1071, 2020.
APA
Wang, Y., Liu, M., Chen, S., & Wu, Q. (2020). Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma. Experimental and Therapeutic Medicine, 19, 1065-1071. https://doi.org/10.3892/etm.2019.8303
MLA
Wang, Y., Liu, M., Chen, S., Wu, Q."Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma". Experimental and Therapeutic Medicine 19.2 (2020): 1065-1071.
Chicago
Wang, Y., Liu, M., Chen, S., Wu, Q."Avicularin inhibits cell proliferation and induces cell apoptosis in cutaneous squamous cell carcinoma". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1065-1071. https://doi.org/10.3892/etm.2019.8303
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