Effects of surgery and radiofrequency ablation in the treatment of spinal metastases and analysis of the influencing factors of prognosis

Li,Meiling; Zhang,Yan; Zhang,Xiujuan

doi:10.3892/etm.2019.8310

Effects of surgery and radiofrequency ablation in the treatment of spinal metastases and analysis of the influencing factors of prognosis

Authors:
- Meiling Li
- Yan Zhang
- Xiujuan Zhang
View Affiliations

Affiliations: Department of Gynecology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of General Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
Published online on: December 10, 2019 https://doi.org/10.3892/etm.2019.8310
Pages: 1072-1078
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Effects of surgery and radiofrequency ablation in the treatment of spinal metastases were explored to analyze the influencing factors of prognosis. A total of 132 patients with spinal metastases admitted to Weifang People's Hospital were selected, 67 patients who underwent simple surgery were selected as the control group, and 65 patients who underwent radiofrequency ablation assisted surgery were the research group. The time of operation and intraoperative blood loss of patients in the two groups were recorded and compared. The visual analogue pain score (VAS), Karnofsky (KPS) score, Frankel spinal cord injury grading, and complications within 6 months after surgery were compared. The patients were followed up for 36 months and the survival rates were analyzed. Cox regression model was used to analyze the factors affecting the prognosis of patients. The time of operation and blood loss in the research group was significantly lower than that in the control group (P<0.05). The VAS, KPS scores, and Frankel grading of patients in the two groups after treatment were significantly improved compared with those before treatment, but the VAS and KPS scores of patients in the research group were significantly improved compared with those in the control group (P<0.05). The incidence rate of complications and 3-year recurrence rate in the research group were lower than those in the control group, and the 3-year survival rate was significantly higher than that in the control group (P<0.05). The number of pathological cones, visceral metastasis, malignant degree, and radiofrequency ablation therapy are independent risk factors for poor prognosis of patients. Radiofrequency ablation assisted surgery can effectively improve the clinical efficacy of patients with spinal metastases, reduce postoperative complications and recurrence rate of patients, and prolong the survival time of patients compared with simple surgical treatment. It is worthy of clinical application.

View Figures

View References

1	Wang J, Fang Z, Lang N, Yuan H, Su MY and Baldi P: A multi-resolution approach for spinal metastasis detection using deep Siamese neural networks. Comput Biol Med. 84:137–146. 2017. View Article : Google Scholar : PubMed/NCBI
2	Roser S, Maharaj MM, Taylor MA, Kuru R, Hansen MA and Ferch R: Vertebrectomy in metastatic spinal tumours: A 10 year, single-centre review of outcomes and survival. J Clin Neurosci. 68:218–223. 2019. View Article : Google Scholar : PubMed/NCBI
3	Gharzai LA, Beeler WH, Hayman JA, Mancini B, Jagsi R, Pierce L, Moran JM, Dominello MM, Boike T, Griffith K, et al Michigan Radiation Oncology Quality Consortium, : Recommendations for single faction radiation therapy and stereotactic body radiation therapy in palliative treatment of bone metastases: A statewide practice patterns survey. Pract Radiat Oncol. 9:e541–e548. 2019. View Article : Google Scholar : PubMed/NCBI
4	Pennington Z, Ahmed AK, Cottrill E, Westbroek EM, Goodwin ML and Sciubba DM: Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: A systematic review and meta-analysis. Ann Transl Med. 7:2182019. View Article : Google Scholar : PubMed/NCBI
5	Schaub SK, Tseng YD, Chang EL, Sahgal A, Saigal R, Hofstetter CP, Foote M, Ko AL, Yuh WTC, Mossa-Basha M, et al: Strategies to mitigate toxicities from stereotactic body radiation therapy for spine metastases. Neurosurgery. 85:729–740. 2019. View Article : Google Scholar : PubMed/NCBI
6	Zhang Y, Zhang MB, Luo YK, Li J, Zhang Y and Tang J: Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma. Cancer Med. 8:5450–5458. 2019. View Article : Google Scholar : PubMed/NCBI
7	Leto G: Current status and future directions in the treatment of bone metastases from breast cancer. Clin Exp Pharmacol Physiol. 46:968–971. 2019. View Article : Google Scholar : PubMed/NCBI
8	van Amerongen MJ, van der Stok EP, Fütterer JJ, Jenniskens SFM, Moelker A, Verhoef C, Grünhagen DJ and de Wilt JHW: Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases. Eur J Surg Oncol. Jul 7–2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
9	Wallace AN, Tomasian A, Vaswani D, Vyhmeister R, Chang RO and Jennings JW: Radiographic local control of spinal metastases with percutaneous radiofrequency ablation and vertebral augmentation. AJNR Am J Neuroradiol. 37:759–765. 2016. View Article : Google Scholar : PubMed/NCBI
10	Cooke ME, Welch T, Gusakov O and Tornetta P III: Are continuous femoral nerve catheters beneficial for pain management after operative fixation of tibial plateau fractures? A randomized controlled trial. J Orthop Trauma. 33:e447–e451. 2019. View Article : Google Scholar : PubMed/NCBI
11	Barbetta C, Allgar V, Maddocks M, Ribeiro C, Wilcock A, Currow DC, Phillips J and Johnson MJ: Australia-modified Karnofsky Performance Scale and physical activity in COPD and lung cancer: An exploratory pooled data analysis. BMJ Support Palliat Care. Jul 11–2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
12	Capaul M, Zollinger H, Satz N, Dietz V, Lehmann D and Schurch B: Analyses of 94 consecutive spinal cord injury patients using ASIA definition and modified Frankel score classification. Paraplegia. 32:583–587. 1994.PubMed/NCBI
13	Buergy D, Sharfo AW, Heijmen BJ, Voet PW, Breedveld S, Wenz F, Lohr F and Stieler F: Fully automated treatment planning of spinal metastases - A comparison to manual planning of Volumetric Modulated Arc Therapy for conventionally fractionated irradiation. Radiat Oncol. 12:332017. View Article : Google Scholar : PubMed/NCBI
14	Hamad A, Vachtsevanos L, Cattell A, Ockendon M and Balain B: Minimally invasive spinal surgery for the management of symptomatic spinal metastasis. Br J Neurosurg. 31:526–530. 2017. View Article : Google Scholar : PubMed/NCBI
15	Guzik G: Oncological and functional results of the surgical treatment of vertebral metastases in patients with multiple myeloma. BMC Surg. 17:922017. View Article : Google Scholar : PubMed/NCBI
16	Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M and Young B: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. Lancet. 366:643–648. 2005. View Article : Google Scholar : PubMed/NCBI
17	de Ruiter GC, Nogarede CO, Wolfs JF and Arts MP: Quality of life after different surgical procedures for the treatment of spinal metastases: Results of a single-center prospective case series. Neurosurg Focus. 42:E172017. View Article : Google Scholar : PubMed/NCBI
18	Kam NM, Maingard J, Kok HK, Ranatunga D, Brooks D, Torreggiani WC, Munk PL, Lee MJ, Chandra RV and Asadi H: Combined vertebral augmentation and radiofrequency ablation in the management of spinal metastases: An update. Curr Treat Options Oncol. 18:742017. View Article : Google Scholar : PubMed/NCBI
19	Griessenauer CJ, Salem M, Hendrix P, Foreman PM, Ogilvy CS and Thomas AJ: Preoperative embolization of spinal tumors: A systematic review and meta-analysis. World Neurosurg. 87:362–371. 2016. View Article : Google Scholar : PubMed/NCBI
20	Stephenson MB, Glaenzer B and Malamis A: Percutaneous minimally invasive techniques in the treatment of spinal metastases. Curr Treat Options Oncol. 17:562016. View Article : Google Scholar : PubMed/NCBI
21	Toyota N, Naito A, Kakizawa H, Hieda M, Hirai N, Tachikake T, Kimura T, Fukuda H and Ito K: Radiofrequency ablation therapy combined with cementoplasty for painful bone metastases: Initial experience. Cardiovasc Intervent Radiol. 28:578–583. 2005. View Article : Google Scholar : PubMed/NCBI
22	Wang GW, Han XX, Ma YL, Duo J, Yang JL and Liao ZC: Radiofrequency ablation combined with subtotal corpectomy for spinal metastases. Chin J Orthop. 31:938–943. 2011.(In Chinese).
23	Hu H, Yang HL, Wang GL, Chen KW, Zhou QS and Zhou M: The decision-making and survival prediction role of Tomita score in the management spinal metastases. Chin J Spin Spin Cord. 22:673–677. 2012.(In Chinese).
24	Hibberd CS and Quan GMY: Accuracy of preoperative scoring systems for the prognostication and treatment of patients with spinal metastases. Int Sch Res Notices. 2017:13206842017.PubMed/NCBI
25	Pointillart V, Vital JM, Salmi R, Diallo A and Quan GM: Survival prognostic factors and clinical outcomes in patients with spinal metastases. J Cancer Res Clin Oncol. 137:849–856. 2011. View Article : Google Scholar : PubMed/NCBI