Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2020 Volume 19 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2020 Volume 19 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma

  • Authors:
    • Zhiyong Huang
    • Ning Zhang
    • Hanxin Cai
    • Kunhui Luo
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1197-1202
    |
    Published online on: December 11, 2019
       https://doi.org/10.3892/etm.2019.8314
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Clinical efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser in the treatment of children with hemangioma was analyzed, to provide a new therapeutic idea for their clinical treatment. A total of 120 children with hemangioma were selected into the study. Children treated with propranolol combined with pulsed dye laser were in group A, those treated with pingyangmycin combined with pulsed dye laser were in group B, and 60 healthy children were selected as control group (group C). Blood samples of children were taken before and after treatment for miR‑4295 detection. The expression of miR‑4295 was observed after treatment, and the total clinical remission rate and adverse reactions after treatment were compared between the two groups. The tumor volume of the two groups was significantly reduced after treatment, with statistically significant difference (P<0.05); miR‑4295 expression was reduced in the two groups (P<0.05); adverse reactions in propranolol group were less than pingyangmycin group during treatment (P<0.05). Propranolol and pingyangmycin, respectively, combined with pulsed dye laser had ideal efficacy on hemangioma in children. Moreover, miR‑4295 was highly expressed in children with hemangioma, and the expression level reduced after two methods of treatment. However, adverse reactions in propranolol group were less and its safety was higher.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Castrén E, Salminen P, Vikkula M, Pitkäranta A and Klockars T: Inheritance patterns of infantile hemangioma. Pediatrics. 138:e201616232016. View Article : Google Scholar : PubMed/NCBI

2 

de Jong S, Itinteang T, Withers AH, Davis PF and Tan ST: Does hypoxia play a role in infantile hemangioma? Arch Dermatol Res. 308:219–227. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Darrow DH, Greene AK, Mancini AJ and Nopper AJ; Section on dermatology, section on otolaryngology-head and neck surgery, section on plastic surgery, : Diagnosis and management of infantile hemangioma: Executive summary. Pediatrics. 136:786–791. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Léauté-Labrèze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, Phillips RJ, Caceres H, Lopez Gutierrez JC, Ballona R, et al: A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med. 372:735–746. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhang L, Yuan WE and Zheng JW: Pharmacological therapies for infantile hemangiomas: A clinical study in 853 consecutive patients using a standard treatment algorithm. Sci Rep. 6:216702016. View Article : Google Scholar : PubMed/NCBI

6 

Chinnadurai S, Sathe NA and Surawicz T: Laser treatment of infantile hemangioma: A systematic review. Lasers Surg Med. 48:221–233. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Nan YH, Wang J, Wang Y, Sun PH, Han YP, Fan L, Wang KC, Shen FJ and Wang WH: MiR-4295 promotes cell growth in bladder cancer by targeting BTG1. Am J Transl Res. 8:4892–4901. 2016.PubMed/NCBI

8 

Zhao F, Yang X, Xu G, Bi J, Lv R and Huo R: Propranolol suppresses HUVEC viability, migration, VEGF expression, and promotes apoptosis by downregulation of miR-4295. J Cell Biochem. 120:6614–6623. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Asilian A, Mokhtari F, Kamali AS, Abtahi-Naeini B, Nilforoushzadeh MA and Mostafaie S: Pulsed dye laser and topical timolol gel versus pulse dye laser in treatment of infantile hemangioma: A double-blind randomized controlled trial. Adv Biomed Res. 4:2572015. View Article : Google Scholar : PubMed/NCBI

10 

Hogeling M, Adams S and Wargon O: A randomized controlled trial of propranolol for infantile hemangiomas. Pediatrics. 128:e259–e266. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Achauer BM, Chang CJ and Vander Kam VM: Management of hemangioma of infancy: Review of 245 patients. Plast Reconstr Surg. 99:1301–1308. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Ji Y, Chen S, Li K, Li L, Xu C and Xiang B: Signaling pathways in the development of infantile hemangioma. J Hematol Oncol. 7:132014. View Article : Google Scholar : PubMed/NCBI

13 

Greenberger S: Infantile Hemangioma[M]//Sex and Dermatology. Springer Cham; New York, NY: pp. 215–225. 2018

14 

Darrow DH, Greene AK, Mancini AJ and Nopper AJ; Section on dermatology, section on otolaryngology-head and neck surgery, section on plastic surgery, : Diagnosis and management of infantile hemangioma. Pediatrics. 136:e1060–e1104. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chinnadurai S, Fonnesbeck C, Snyder KM, Sathe NA, Morad A, Likis FE and McPheeters ML: Pharmacologic interventions for infantile hemangioma: A meta-analysis. Pediatrics. 137:e201538962016. View Article : Google Scholar : PubMed/NCBI

16 

Léaute-Labrèze C, Boccara O, Degrugillier-Chopinet C, Mazereeuw-Hautier J, Prey S, Lebbé G, Gautier S, Ortis V, Lafon M, Montagne A, et al: Safety of oral propranolol for the treatment of infantile hemangioma: A systematic review. Pediatrics. 138:e201603532016. View Article : Google Scholar : PubMed/NCBI

17 

Ng M, Knuth C, Weisbrod C and Murthy A: Propranolol therapy for problematic infantile hemangioma. Ann Plast Surg. 76:306–310. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Hou J, Wang M, Tang H, Wang Y and Huang H: Pingyangmycin sclerotherapy for infantile hemangiomas in oral and maxillofacial regions: An evaluation of 66 consecutive patients. Int J Oral Maxillofac Surg. 40:1246–1251. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Huang Y, Li P, Xia S, Zhuo Y and Wu L: Proapoptotic effect and the mechanism of action of pingyangmycin on cavernous hemangiomas. Exp Ther Med. 7:473–477. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Tu JB, Li QY, Jiang F, Hu XY, Ma RZ, Dong Q, Zhang H, Pattar P and Li SX: Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway. Mol Med Rep. 10:301–305. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Kwon SH, Choi JW, Byun SY, Kim BR, Park KC, Youn SW, Huh CH and Na JI: Effect of early long-pulse pulsed dye laser treatment in infantile hemangiomas. Dermatol Surg. 40:405–411. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Kessels JP, Hamers ET and Ostertag JU: Superficial hemangioma: Pulsed dye laser versus wait-and-see. Dermatol Surg. 39:414–421. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Bertoni N, Pereira LM, Severino FE, Moura R, Yoshida WB and Reis PP: Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma. BMC Med Genet. 17:42016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Zhang N, Cai H and Luo K: Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma. Exp Ther Med 19: 1197-1202, 2020.
APA
Huang, Z., Zhang, N., Cai, H., & Luo, K. (2020). Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma. Experimental and Therapeutic Medicine, 19, 1197-1202. https://doi.org/10.3892/etm.2019.8314
MLA
Huang, Z., Zhang, N., Cai, H., Luo, K."Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma". Experimental and Therapeutic Medicine 19.2 (2020): 1197-1202.
Chicago
Huang, Z., Zhang, N., Cai, H., Luo, K."Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1197-1202. https://doi.org/10.3892/etm.2019.8314
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Zhang N, Cai H and Luo K: Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma. Exp Ther Med 19: 1197-1202, 2020.
APA
Huang, Z., Zhang, N., Cai, H., & Luo, K. (2020). Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma. Experimental and Therapeutic Medicine, 19, 1197-1202. https://doi.org/10.3892/etm.2019.8314
MLA
Huang, Z., Zhang, N., Cai, H., Luo, K."Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma". Experimental and Therapeutic Medicine 19.2 (2020): 1197-1202.
Chicago
Huang, Z., Zhang, N., Cai, H., Luo, K."Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1197-1202. https://doi.org/10.3892/etm.2019.8314
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team