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Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness

  • Authors:
    • Zhenxiang Dai
    • Yang Jiao
    • Qingxian Fan
    • Anning Qi
    • Liang Xiao
    • Jingwei Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, People's Hospital of Liuhe District of Nanjing, Nanjing, Jiangsu 211500, P.R. China, Department of Medical Imaging, People's Hospital of Liuhe District of Nanjing, Nanjing, Jiangsu 211500, P.R. China, Department of Laboratory Medicine, People's Hospital of Liuhe District of Nanjing, Nanjing, Jiangsu 211500, P.R. China, Department of Emergency, People's Hospital of Liuhe District of Nanjing, Nanjing, Jiangsu 211500, P.R. China, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1167-1174
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    Published online on: December 13, 2019
       https://doi.org/10.3892/etm.2019.8326
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Abstract

Diabetes mellitus complicated with cerebral infarction (DMCI) has a high incidence and disability rate. Therefore, identification of biomarkers for the early prediction of the development and progression of cerebral infarction (CI) is of great significance for the prevention and treatment of this disease. The roles of serum homocysteine (Hey), interleukin‑1β (IL‑1β), and fasting blood glucose (FBG) in DMCI and their correlations with carotid intima‑media thickness (CIMT) were explored. A total of 124 patients with DMCI (DMCI group) and 103 patients with diabetes mellitus (DM) (DM group) admitted to the People's Hospital of Liuhe District of Nanjing were enrolled in this study. A further 100 healthy controls undergoing physical examinations during the same period (HC group) were also enrolled. CIMT value was detected by carotid artery ultrasound. Hey and FBG levels were determined by a fully automatic biochemical analyzer. The IL‑1β level was detected by enzyme‑linked immunosorbent assay (ELISA). The levels of Hey, IL‑1β, and FBG and the CIMT value in the DMCI and DM groups were significantly higher than those in the HC group (P<0.001). The levels and the value in the DMCI group were significantly higher than those in the DM group (P<0.001). Hey, IL‑1β, and FBG levels were positively correlated with CIMT value (r=0.542, P<0.001; r=0.522, P<0.001; r=0.402, P<0.001). Receiver operating characteristic (ROC) curves showed that the sensitivity and specificity of Hey for diagnosing DMCI were 86.29 and 80.58%; those of IL‑1β were 68.55 and 86.41%; those of FBG were 69.35 and 88.35%. Multivariate logistic regression analysis revealed that systolic blood pressure (SBP), diastolic blood pressure (DBP), high‑density lipoprotein cholesterol (HDL‑C), low‑density lipoprotein cholesterol (LDL‑C), Hey, IL‑1β, FBG, and CIMT were independent risk factors for DMCI (P<0.05). In conclusion, patients with DMCI have severe atherosclerosis. Hey, IL‑1β, and FBG are involved in the development and progression of DMCI, so they can be used as predictive markers for the disease. Hey, IL‑1β, FBG, and CIMT are independent risk factors for patients with DMCI.
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Copy and paste a formatted citation
Spandidos Publications style
Dai Z, Jiao Y, Fan Q, Qi A, Xiao L and Li J: Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness. Exp Ther Med 19: 1167-1174, 2020.
APA
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., & Li, J. (2020). Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness. Experimental and Therapeutic Medicine, 19, 1167-1174. https://doi.org/10.3892/etm.2019.8326
MLA
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., Li, J."Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness". Experimental and Therapeutic Medicine 19.2 (2020): 1167-1174.
Chicago
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., Li, J."Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1167-1174. https://doi.org/10.3892/etm.2019.8326
Copy and paste a formatted citation
x
Spandidos Publications style
Dai Z, Jiao Y, Fan Q, Qi A, Xiao L and Li J: Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness. Exp Ther Med 19: 1167-1174, 2020.
APA
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., & Li, J. (2020). Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness. Experimental and Therapeutic Medicine, 19, 1167-1174. https://doi.org/10.3892/etm.2019.8326
MLA
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., Li, J."Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness". Experimental and Therapeutic Medicine 19.2 (2020): 1167-1174.
Chicago
Dai, Z., Jiao, Y., Fan, Q., Qi, A., Xiao, L., Li, J."Homocysteine, interleukin‑1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima‑media thickness". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1167-1174. https://doi.org/10.3892/etm.2019.8326
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