Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2020 Volume 19 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2020 Volume 19 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol

  • Authors:
    • Xianli Yao
    • Li Li
    • Amit D. Kandhare
    • Anwesha A. Mukherjee‑Kandhare
    • Subhash L. Bodhankar
  • View Affiliations / Copyright

    Affiliations: Department of Neurological Rehabilitation, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Encephalopathy Department, The Traditional Chinese Medicine Hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune‑411038, Maharashtra, India
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1343-1355
    |
    Published online on: December 13, 2019
       https://doi.org/10.3892/etm.2019.8328
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Fibromyalgia (FM) is a chronic complex musculoskeletal disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep disturbance, memory defects and mood changes. Fisetin, a plant flavonoid polyphenol, has been reported to possess potent antioxidant, antinociceptive and neuroprotective activities. The present study aimed to evaluate the efficacy of fisetin against reserpine‑induced FM (RIF) in rats. RIF was induced in male Wistar rats (180‑220 gm) using reserpine (1 mg/kg; subcutaneous; once daily for 3 consecutive days) and the rats were treated with fisetin (5, 10 and 25 mg/kg) for 21 days. Various behavioral, biochemical and molecular parameters were evaluated. Administration of reserpine induced allodynia, hyperalgesia and depression, which were significantly ameliorated (P<0.05) by fisetin (10 and 25 mg/kg), as reflected by an increase in paw and tail withdrawal latency, increased paw withdrawal threshold, and decreased immobility time. Reserpine led to decreased biogenic amine levels [5‑hydroxytryptamine (5‑HT), noradrenaline (NA) and dopamine (DA)] and increased the ratio to their metabolite 3,4‑dihydroxyphenylacetic acid. 5‑hydroxyindoleacetic acid in the spinal cord, thalamus and prefrontal cortex was significantly decreased (P<0.05) by fisetin. Immunohistological analysis of brain tissue revealed that fisetin significantly inhibited (P<0.05) reserpine‑induced depletion of 5‑HT. It also significantly inhibited (P<0.05) elevated oxido‑nitrosative stress and reactive oxygen species (ROS) levels, as analyzed by flow cytometry in RIF rats. Fisetin exerts its antinociceptive and anti‑depressive potential via modulation of decreased levels of biogenic amines (5‑HT, NA and DA), elevated oxido‑nitrosative stress and ROS to ameliorate allodynia, hyperalgesia, and depression in experimental RIF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Maletic V and Raison CL: Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosci (Landmark Ed). 14:5291–5338. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Staud R and Rodriguez ME: Mechanisms of disease: Pain in fibromyalgia syndrome. Nat Clin Pract Rheumatol. 2:90–98. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Walitt B, Nahin RL, Katz RS, Bergman MJ and Wolfe F: The prevalence and characteristics of fibromyalgia in the 2012 national health interview survey. PLoS One. 10:e01380242015. View Article : Google Scholar : PubMed/NCBI

4 

Borchers AT and Gershwin ME: Fibromyalgia: A critical and comprehensive review. Clin Rev Allergy Immunol. 49:100–151. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Arnold LM: Biology and therapy of fibromyalgia. New therapies in fibromyalgia. Arthritis Res Ther. 8:2122006. View Article : Google Scholar : PubMed/NCBI

6 

Ghavidel-Parsa B, Bidari A, Amir Maafi A and Ghalebaghi B: the iceberg nature of fibromyalgia burden: The clinical and economic aspects. Korean J Pain. 28:169–176. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wood PB, Holman AJ and Jones KD: Novel pharmacotherapy for fibromyalgia. Expert Opin Investig Drugs. 16:829–841. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Dadabhoy D, Crofford LJ, Spaeth M, Russell IJ and Clauw DJ: Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome. Arthritis Res Ther. 10:2112008. View Article : Google Scholar : PubMed/NCBI

9 

Russell IJ, Vaeroy H, Javors M and Nyberg F: Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum. 35:550–556. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Mense S: Neurobiological concepts of fibromyalgia-the possible role of descending spinal tracts. Scand J Rheumatol Suppl. 113:24–29. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Wasik A, Romanska I and Antkiewicz-Michaluk L: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-inducing toxin, strongly potentiates MAO-dependent dopamine oxidation and impairs dopamine release: Ex vivo and in vivo neurochemical studies. Neurotox Res. 15:15–23. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Sánchez-Domínguez B, Bullón P, Román-Malo L, Marín-Aguilar F, Alcocer-Gómez E, Carrión AM, Sánchez-Alcazar JA and Cordero MD: Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with fibromyalgia. Mitochondrion. 21:69–75. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Bjorklund G, Dadar M, Chirumbolo S and Aaseth J: Fibromyalgia and nutrition: Therapeutic possibilities? Biomed Pharmacother. 103:531–538. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Cordero MD, de Miguel M, Carmona-López I, Bonal P, Campa F and Moreno-Fernández AM: Oxidative stress and mitochondrial dysfunction in fibromyalgia. Neuro Endocrinol Lett. 31:169–173. 2010.PubMed/NCBI

15 

Bateman L, Palmer RH, Trugman JM and Lin Y: Results of switching to milnacipran in fibromyalgia patients with an inadequate response to duloxetine: A phase IV pilot study. J Pain Res. 6:311–318. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Siler AC, Gardner H, Yanit K, Cushman T and McDonagh M: Systematic review of the comparative effectiveness of antiepileptic drugs for fibromyalgia. J Pain. 12:407–415. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Younger J, Noor N, McCue R and Mackey S: Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis Rheum. 65:529–538. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Hadikusumo B and Ng B: Serotonin syndrome induced by duloxetine. Aust N Z J Psychiatry. 43:581–582. 2009.PubMed/NCBI

19 

Nüesch E, Häuser W, Bernardy K, Barth J and Jüni P: Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: Network meta-analysis. Ann Rheum Dis. 72:955–962. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Hussain SA, Al K II, Jasim NA and Gorial FI: Adjuvant use of melatonin for treatment of fibromyalgia. J Pineal Res. 50:267–271. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Gilron I, Tu D, Holden R, Towheed T, Ziegler D, Wang L, Milev R and Gray C: Innovations in the management of musculoskeletal pain with alpha-lipoic acid (IMPALA Trial): Study protocol for a double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain. JMIR Res Protoc. 6:e412017. View Article : Google Scholar : PubMed/NCBI

22 

Nagakura Y: Recent advancements in animal models of fibromyalgia. Myopain. 23:104–111. 2015. View Article : Google Scholar

23 

La Torre F and Nicolai AP: Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: Results of a randomized, controlled, clinical trial. Dis Colon Rectum. 47:704–710. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Fiorani M, Accorsi A and Cantoni O: Human red blood cells as a natural flavonoid reservoir. Free Radic Res. 37:1331–1338. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Maher P, Dargusch R, Bodai L, Gerard PE, Purcell JM and Marsh JL: ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum Mol Genet. 20:261–270. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Mazzio EA, Harris N and Soliman KF: Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med. 64:603–606. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Maher P: The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity. Arch Biochem Biophys. 476:139–144. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Maher P: Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr. 4:297–307. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Maher P, Dargusch R, Ehren JL, Okada S, Sharma K and Schubert D: Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One. 6:e212262011. View Article : Google Scholar : PubMed/NCBI

30 

Kandhare AD, Raygude KS, Ghosh P and Bodhankar SL: The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Inter J Green Pharmacy. 5:236–243. 2011. View Article : Google Scholar

31 

Raygude KS, Kandhare AD, Ghosh P and Bodhankar SL: Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr. 2:215–222. 2012. View Article : Google Scholar

32 

Zhao L, Kandhare A, Mukherjee A and Bodhankar S: Anti-allergic potential of fisetin in a murine model of OVA-induced allergic rhinitis via inhibition of GATA-3 and Th2 cytokines. Biomedica. 34:88–101. 2018.

33 

Ma T, Kandhare AD, Mukherjee-Kandhare AA and Bodhankar SL: Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: The decisive role of caspase-3, COX–II, cTn-I, iNOs and TNF-α. Mol Biol Rep. 46:105–118. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zhen L, Zhu J, Zhao X, Huang W, An Y, Li S, Du X, Lin M, Wang Q, Xu Y and Pan J: The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system. Behav Brain Res. 228:359–366. 2012. View Article : Google Scholar : PubMed/NCBI

35 

CPCSEA: Committee for the purpose of control and supervision of experiments on animals. 1991.

36 

Nagakura Y, Oe T, Aoki T and Matsuoka N: Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. Pain. 146:26–33. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Kamble H, Kandhare AD, Bodhankar S, Mohan V and Thakurdesai P: Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol. 3:145–151. 2013. View Article : Google Scholar

38 

Kandhare AD, Raygude KS, Ghosh P, Ghule AE and Bodhankar SL: Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia. 83:650–659. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Kandhare AD, Raygude KS, Ghosh P, Ghule AE and Bodhankar SL: Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett. 511:18–22. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS and Bodhankar SL: Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 38:996–1006. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Adil M, Kandhare AD, Ghosh P and Bodhankar SL: Sodium arsenite-induced myocardial bruise in rats: Ameliorative effect of naringin via TGF-β/Smad and Nrf/HO pathways. Chem Biol Interact. 253:66–77. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Kandhare AD, Alam J, Patil MV, Sinha A and Bodhankar SL: Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats. Pharm Biol. 54:419–432. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Kandhare AD, Raygude KS, Kumar VS, Rajmane AR, Visnagri A, Ghule AE, Ghosh P, Badole SL and Bodhankar SL: Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol. 2:173–186. 2012. View Article : Google Scholar

44 

Visnagri A, Kandhare AD and Bodhankar SL: Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. Ren Fail. 37:482–493. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Blasco-Serra A, Escrihuela-Vidal F, Gonzalez-Soler EM, Martínez-Expósito F, Blasco-Ausina MC, Martínez-Bellver S, Cervera-Ferri A, Teruel-Martí V and Valverde-Navarro AA: Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats. Physiol Behav. 151:456–462. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Ghule AE, Kandhare AD, Jadhav SS, Zanwar AA and Bodhankar SL: Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis. Int Immunopharmacol. 28:751–763. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhang L, Wu T, Kandhare A, Mukherjee A, Guo G and Bodhankar S: Elucidation of the molecular mechanism of tempol in pentylenetetrazol-induced epilepsy in mice: Role of gamma-aminobutyric acid, tumor necrosis factor-alpha, interleukin-1&#946; and c-Fos. Pharm Mag. 14:520–527. 2018. View Article : Google Scholar

48 

Antkiewicz-Michaluk L, Wasik A, Możdżeń E, Romańska I and Michaluk J: Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: Behavioral and neurochemical studies in the rat. Neurotox Res. 26:85–98. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Horiuchi H, Ogata T, Morino T, Takeba J and Yamamoto H: Serotonergic signaling inhibits hyperalgesia induced by spinal cord damage. Brain Res. 963:312–320. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Willis WD and Westlund KN: Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol. 14:2–31. 1997. View Article : Google Scholar : PubMed/NCBI

51 

Legangneux E, Mora JJ, Spreux-Varoquaux O, Thorin I, Herrou M, Alvado G and Gomeni C: Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. Rheumatology (Oxford). 40:290–296. 2001. View Article : Google Scholar : PubMed/NCBI

52 

de Souza AH, da Costa Lopes AM, Castro CJ Jr, Pereira EM, Klein CP, da Silva CA Jr, da Silva JF, Ferreira J and Gomez MV: The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. Toxicon. 81:37–42. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Borsook D, Moulton EA, Tully S, Schmahmann JD and Becerra L: Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects. Cerebellum. 7:252–272. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Seifert F, Jungfer I, Schmelz M and Maihofner C: Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: A functional MRI study. Hum Brain Mapp. 29:1327–1342. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Kaufman J, DeLorenzo C, Choudhury S and Parsey RV: The 5-HT1A receptor in major depressive disorder. Eur Neuropsychopharmacol. 26:397–410. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Charbit AR, Akerman S and Goadsby PJ: Comparison of the effects of central and peripheral dopamine receptor activation on evoked firing in the trigeminocervical complex. J Pharmacol Exp Ther. 331:752–763. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Pertovaara A: Noradrenergic pain modulation. Prog Neurobiol. 80:53–83. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Zhao X, Li XL, Liu X, Wang C, Zhou DS, Ma Q, Zhou WH and Hu ZY: Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors. Pharmacol Res. 102:286–297. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Glass JM: Review of cognitive dysfunction in fibromyalgia: A convergence on working memory and attentional control impairments. Rheum Dis Clin North Am. 35:299–311. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Surmeier DJ, Shen W, Day M, Gertler T, Chan S, Tian X and Plotkin JL: The role of dopamine in modulating the structure and function of striatal circuits. Prog Brain Res. 183:149–167. 2010.PubMed/NCBI

61 

Belujon P and Grace AA: Dopamine system dysregulation in major depressive disorders. Int J Neuropsychopharmacol. 20:1036–1046. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Leith NJ and Barrett RJ: Effects of chronic amphetamine or reserpine on self-stimulation responding: Animal model of depression? Psychopharmacology (Berl). 72:9–15. 1980. View Article : Google Scholar : PubMed/NCBI

63 

Franberg O, Marcus MM and Svensson TH: Involvement of 5-HT2A receptor and α2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow. Synapse. 66:650–660. 2012. View Article : Google Scholar : PubMed/NCBI

64 

Kulkarni SK and Dhir A: On the mechanism of antidepressant-like action of berberine chloride. Eur J Pharmacol. 589:163–172. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Freitas AE, Budni J, Lobato KR, Binfaré RW, Machado DG, Jacinto J, Veronezi PO, Pizzolatti MG and Rodrigues AL: Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: Evidence for the involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry. 34:335–343. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Johnels B: Locomotor hypokinesia in the reserpine-treated rat: Drug effects from the corpus striatum and nucleus accumbens. Pharmacol Biochem Behav. 17:283–289. 1982. View Article : Google Scholar : PubMed/NCBI

67 

Kandhare AD, Mukherjee AA and Bodhankar SL: Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress. Asian Pac J Trop Biomed. 8:352–359. 2018. View Article : Google Scholar

68 

Okifuji A, Gao J, Bokat C and Hare BD: Management of fibromyalgia syndrome in 2016. Pain Manag. 6:383–400. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Cordero MD, Alcocer-Gómez E, Cano-Garcia FJ, De Miguel M, Carrión AM, Navas P and Sánchez Alcázar JA: Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. PLoS One. 6:e269152011. View Article : Google Scholar : PubMed/NCBI

70 

Bilska A, Dubiel M, Sokolowska-Jezewicz M, Lorenc-Koci E and Włodek L: Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience. 146:1758–1771. 2007. View Article : Google Scholar : PubMed/NCBI

71 

Cui J, Wang G, Kandhare AD, Mukherjee-Kandhare AA and Bodhankar SL: Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3. Food Chem Toxicol. 121:95–108. 2018. View Article : Google Scholar : PubMed/NCBI

72 

Rajendran M and Ramachandran R: Fisetin protects against rotenone-induced neurotoxicity through signaling pathway. Front Biosci (Elite Ed). 11:20–28. 2019.PubMed/NCBI

73 

Boomershine CS: Pregabalin for the management of fibromyalgia syndrome. J Pain Res. 3:81–88. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Kim L, Lipton S and Deodhar A: Pregabalin for fibromyalgia: Some relief but no cure. Cleve Clin J Med. 76:255–261. 2009. View Article : Google Scholar : PubMed/NCBI

75 

Gao GM, Jiang L, Liu SY, Zheng ZH and Liu ZS: A randomized and controlled study of clinical efficacy for total flavone of Rhizoma Drynariae on fibromyalgia syndrome. Chin J New Drug Clin Remedies. 26:837–840. 2007.

76 

Farsad-Naeimi A, Alizadeh M, Esfahani A and Darvish Aminabad E: Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food Funct. 9:2025–2031. 2018. View Article : Google Scholar : PubMed/NCBI

77 

Mehta P, Pawar A, Mahadik K and Bothiraja C: Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. Biomed Pharmacother. 106:1282–1291. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao X, Li L, Kandhare AD, Mukherjee‑Kandhare AA and Bodhankar SL: Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol. Exp Ther Med 19: 1343-1355, 2020.
APA
Yao, X., Li, L., Kandhare, A.D., Mukherjee‑Kandhare, A.A., & Bodhankar, S.L. (2020). Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol. Experimental and Therapeutic Medicine, 19, 1343-1355. https://doi.org/10.3892/etm.2019.8328
MLA
Yao, X., Li, L., Kandhare, A. D., Mukherjee‑Kandhare, A. A., Bodhankar, S. L."Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol". Experimental and Therapeutic Medicine 19.2 (2020): 1343-1355.
Chicago
Yao, X., Li, L., Kandhare, A. D., Mukherjee‑Kandhare, A. A., Bodhankar, S. L."Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1343-1355. https://doi.org/10.3892/etm.2019.8328
Copy and paste a formatted citation
x
Spandidos Publications style
Yao X, Li L, Kandhare AD, Mukherjee‑Kandhare AA and Bodhankar SL: Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol. Exp Ther Med 19: 1343-1355, 2020.
APA
Yao, X., Li, L., Kandhare, A.D., Mukherjee‑Kandhare, A.A., & Bodhankar, S.L. (2020). Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol. Experimental and Therapeutic Medicine, 19, 1343-1355. https://doi.org/10.3892/etm.2019.8328
MLA
Yao, X., Li, L., Kandhare, A. D., Mukherjee‑Kandhare, A. A., Bodhankar, S. L."Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol". Experimental and Therapeutic Medicine 19.2 (2020): 1343-1355.
Chicago
Yao, X., Li, L., Kandhare, A. D., Mukherjee‑Kandhare, A. A., Bodhankar, S. L."Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1343-1355. https://doi.org/10.3892/etm.2019.8328
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team