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Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study

  • Authors:
    • Xin Wang
    • Mengmeng Han
    • Shan He
    • Yuan Zhang
    • Xiaorong Xu
    • Yuxing Wang
    • Caijing Dang
    • Juan Zhang
    • Hua Wang
    • Mulei Chen
    • Jiamei Liu
    • Dongyan Hou
    • Wenshu Zhao
    • Lin Xu
    • Lin Zhang
  • View Affiliations / Copyright

    Affiliations: Heart Center and Beijing Key Laboratory of Hypertension Research, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China, Heart Center, Beijing Chaoyang Hospital Jingxi Branch, Capital Medical University, Beijing 100020, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1259-1266
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    Published online on: December 16, 2019
       https://doi.org/10.3892/etm.2019.8331
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Abstract

A number of studies have suggested that autoantibodies against β1‑adrenoreceptors (β1R‑AAbs) have an important role in pathophysiological processes of heart failure. The aim of the present study was to determine whether β1R‑AAbs are implicated in cardiac dysfunction following acute myocardial infarction (AMI) and their association with prognosis. A total of 33 cases with systolic heart failure (SHF), 49 with diastolic heart failure (DHF) and 44 with normal heart function following AMI were recruited. β1R‑AAbs were detected by ELISA and major adverse cardiac events (MACEs) were recorded during the 5‑year follow‑up. The positive rate of β1R‑AAbs in the SHF group (45.5%) was significantly higher compared with that in the DHF (22.4%; P<0.05) and normal (15.9%; P<0.05) groups. The area under the receiver operating characteristics curve for the diagnosis of SHF was 0.630 (95% CI: 0.514‑0.747, P=0.026). During a median follow‑up period of 51.0±15.4 months, the positive rate of β1R‑AAbs in the MACEs group was significantly higher compared with that in the non‑MACEs group (P<0.05). Multivariate logistic regression analysis indicated that the left ventricular ejection fraction and diabetes were independent predictors of 5‑year MACEs following AMI, whereas β1R‑AAbs were not. Kaplan‑Meier analysis revealed that the cumulative MACEs‑free survival rate was the lowest in the SHF group, followed by the DHF and normal groups (P<0.05). Therefore, β1R‑AAbs were indicated to be of value for early diagnosis of SHF after AMI but not as independent predictors for the prognosis of patients with AMI.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Han M, He S, Zhang Y, Xu X, Wang Y, Dang C, Zhang J, Wang H, Chen M, Chen M, et al: Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study. Exp Ther Med 19: 1259-1266, 2020.
APA
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y. ... Zhang, L. (2020). Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study. Experimental and Therapeutic Medicine, 19, 1259-1266. https://doi.org/10.3892/etm.2019.8331
MLA
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y., Dang, C., Zhang, J., Wang, H., Chen, M., Liu, J., Hou, D., Zhao, W., Xu, L., Zhang, L."Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study". Experimental and Therapeutic Medicine 19.2 (2020): 1259-1266.
Chicago
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y., Dang, C., Zhang, J., Wang, H., Chen, M., Liu, J., Hou, D., Zhao, W., Xu, L., Zhang, L."Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1259-1266. https://doi.org/10.3892/etm.2019.8331
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Han M, He S, Zhang Y, Xu X, Wang Y, Dang C, Zhang J, Wang H, Chen M, Chen M, et al: Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study. Exp Ther Med 19: 1259-1266, 2020.
APA
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y. ... Zhang, L. (2020). Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study. Experimental and Therapeutic Medicine, 19, 1259-1266. https://doi.org/10.3892/etm.2019.8331
MLA
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y., Dang, C., Zhang, J., Wang, H., Chen, M., Liu, J., Hou, D., Zhao, W., Xu, L., Zhang, L."Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study". Experimental and Therapeutic Medicine 19.2 (2020): 1259-1266.
Chicago
Wang, X., Han, M., He, S., Zhang, Y., Xu, X., Wang, Y., Dang, C., Zhang, J., Wang, H., Chen, M., Liu, J., Hou, D., Zhao, W., Xu, L., Zhang, L."Diagnostic and prognostic value of autoantibodies against β1‑adrenoreceptors in patients with heart failure following acute myocardial infarction: A 5‑year prospective study". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1259-1266. https://doi.org/10.3892/etm.2019.8331
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