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Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI

  • Authors:
    • Jujun Xue
    • Cuiqing Wang
    • Chengli Pan
    • Haining Xing
    • Lijuan Xu
    • Xi Chen
    • Xuping Wang
    • Na Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gerontological Neurology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Pediatric Clinic, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Mass Control Office, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Endocrinology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Experimental Diagnosis, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Medical Affairs, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1356-1362
    |
    Published online on: December 17, 2019
       https://doi.org/10.3892/etm.2019.8339
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Abstract

The aim of this study was to investigate the effect of dipeptidyl peptidase-4 (DPP-4) inhibitor on blood sugar level and cognitive ability in elderly patients with type 2 diabetes mellitus (T2DM) combined with post-stroke mild cognitive impairment (MCI). Thirty patients received DPP-4 inhibitor (study group), while another thirty received sulfonylurea (control group).Six months after treatment, markers regarding blood sugar were improved in both groups (all P<0.05) without intergroup differences (all P>0.05); scores regarding cognitive ability improved in the study group (both P<0.05) and were higher versus the control group (both P<0.01); the study group had higher Aβ1-42/Aβ1-40 value versus the pretreatment value (P<0.001), which differed from the control group (P<0.05); tumor necrosis factor-α and interleukin-6 concentrations decreased in both groups, while the study group had greater reductions; C-reactive protein value decreased after treatment in the study group (all P<0.05).Using DPP-4 inhibitor in elderly patients with T2DM combined with post-stroke MCI can lower blood sugar and improve cognitive ability. The mechanism may be associated with the improvement of Aβ gathering and reduction in inflammatory response.
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Copy and paste a formatted citation
Spandidos Publications style
Xue J, Wang C, Pan C, Xing H, Xu L, Chen X, Wang X and Wang N: Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI. Exp Ther Med 19: 1356-1362, 2020.
APA
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X. ... Wang, N. (2020). Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI. Experimental and Therapeutic Medicine, 19, 1356-1362. https://doi.org/10.3892/etm.2019.8339
MLA
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X., Wang, X., Wang, N."Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI". Experimental and Therapeutic Medicine 19.2 (2020): 1356-1362.
Chicago
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X., Wang, X., Wang, N."Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1356-1362. https://doi.org/10.3892/etm.2019.8339
Copy and paste a formatted citation
x
Spandidos Publications style
Xue J, Wang C, Pan C, Xing H, Xu L, Chen X, Wang X and Wang N: Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI. Exp Ther Med 19: 1356-1362, 2020.
APA
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X. ... Wang, N. (2020). Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI. Experimental and Therapeutic Medicine, 19, 1356-1362. https://doi.org/10.3892/etm.2019.8339
MLA
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X., Wang, X., Wang, N."Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI". Experimental and Therapeutic Medicine 19.2 (2020): 1356-1362.
Chicago
Xue, J., Wang, C., Pan, C., Xing, H., Xu, L., Chen, X., Wang, X., Wang, N."Effect of DPP-4 inhibitor on elderly patients with T2DM combined with MCI". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1356-1362. https://doi.org/10.3892/etm.2019.8339
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