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Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients

  • Authors:
    • Miao Zheng
    • Yanlin Zheng
    • Mingmin Gao
    • Hongjie Ma
    • Xinyue Zhang
    • Yuanyuan Li
    • Fang Wang
    • Hui Huang
  • View Affiliations / Copyright

    Affiliations: College of Ophthalmology, Chengdu University of Traditional Chinese Madicine, Chengdu, Sichuan 610072, P.R. China, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China, Henan Provincial People's Hospital, Henan Eye Hospital and Henan Eye Institute, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China, Zhengzhou BoAi Eye, Pharyngeal, Ear, Nose and Throat Hospital, Zhengzhou, Henan 450003, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1329-1335
    |
    Published online on: December 18, 2019
       https://doi.org/10.3892/etm.2019.8345
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Abstract

Expression and clinical value of long non‑coding RNA (lncRNA) MALAT1 and lncRNA ANRIL in glaucoma patients were investigated. Altogether 86 glaucoma patients who were diagnosed (study group) and 86 people who underwent physical examinations and were confirmed to be healthy (control group) in the Hospital of Chengdu University of Traditional Chinese Medicine from January 2016 to June 2018 were enrolled. Expression of the serum lncRNA MALAT1, lncRNA ANRIL, pigment epithelium‑derived factor (PEDF), homocysteine (Hcy), and inflammatory cytokines [interleukin‑12 (IL‑12), interleukin‑4 (IL‑4) and interferon‑γ (IFN‑γ)] was detected. The clinical significance of lncRNA MALAT1 and lncRNA ANRIL was analyzed. Compared with those in the control group, patients in the study group had significantly lower expression of serum lncRNA MALAT1 and lncRNA ANRIL (P<0.05), significantly lower expression of serum PEDF and IL‑12 (P<0.05), and significantly higher expression of serum Hcy and IL‑4 (P<0.05), without significant difference in the expression of serum IFN‑γ between the two groups (P>0.05). Serum lncRNA MALAT1 and lncRNA ANRIL were positively correlated with PEDF and IL‑12 (P<0.05), but negatively correlated with Hcy and IL‑4 (P<0.05). The diagnostic value of the combined detection of lncRNA MALAT1 and lncRNA ANRIL was higher than that of lncRNA MALAT1 alone and lncRNA ANRIL alone. The expression of lncRNA MALAT1 and lncRNA ANRIL was significantly related to the pathological staging of the patients (P<0.05), not the sex, age, body mass index (BMI), types, and presence or absence of myopia (P>0.05). lncRNA MALAT1 and lncRNA ANRIL are poorly expressed in the serum of glaucoma patients and related to the patients' conditions. Their combined detection has high diagnostic value for the disease. Therefore, they may be used as new molecular targets for the diagnosis and severity evaluation of glaucoma patients.
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1 

Bashir H, Sridhar U, Mazumdar S and Tripathy K: Panscleritis masquerading as an attack of primary acute angle closure glaucoma. GMS Ophthalmol Cases. 9:Doc312019.PubMed/NCBI

2 

Youngblood H, Hauser MA and Liu Y: Update on the genetics of primary open-angle glaucoma. Exp Eye Res. 188:1077952019. View Article : Google Scholar : PubMed/NCBI

3 

Weinreb RN and Khaw PT: Primary open-angle glaucoma. Lancet. 363:1711–1720. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Ribeiro A, Veiga F, Santos D, Torres-Labandeira JJ, Concheiro A and Alvarez-Lorenzo C: Hydrophilic acrylic hydrogels with built-in or pendant cyclodextrins for delivery of anti-glaucoma drugs. Carbohydr Polym. 88:977–985. 2012. View Article : Google Scholar

5 

Garcia-Medina JJ, Garcia-Medina M, Garrido-Fernandez P, Galvan-Espinosa J, Garcia-Maturana C, Zanon-Moreno V and Pinazo-Duran MD: A two-year follow-up of oral antioxidant supplementation in primary open-angle glaucoma: An open-label, randomized, controlled trial. Acta Ophthalmol. 93:546–554. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Islam MN, Moriam S, Umer M, Phan HP, Salomon C, Kline R, Nguyen NT and Shiddiky MJ: Naked-eye and electrochemical detection of isothermally amplified HOTAIR long non-coding RNA. Analyst (Lond). 143:3021–3028. 2018. View Article : Google Scholar

7 

Ying L, Chen Q, Wang Y, Zhou Z, Huang Y and Qiu F: Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst. 8:2289–2294. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Li HB, You QS, Xu LX, Sun LX, Abdul Majid AS, Xia XB and Ji D: Long non-coding RNA-MALAT1 mediates retinal ganglion cell apoptosis through the PI3K/Akt signaling pathway in rats with glaucoma. Cell Physiol Biochem. 43:2117–2132. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhao J, Sun H, Zhang JM, Wang M, Du XJ and Zhang JL: Long non-coding RNA ANRIL downregulates microRNA-7 to protect human trabecular meshwork cells in an experimental model for glaucoma. Eur Rev Med Pharmacol Sci. 23:3173–3182. 2019.PubMed/NCBI

10 

Francis BA, Varma R, Vigen C, Lai MY, Winarko J, Nguyen B and Azen S; Los Angeles Latino Eye Study Group, : Population and high-risk group screening for glaucoma: The Los Angeles Latino Eye Study. Invest Ophthalmol Vis Sci. 52:6257–6264. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Johnson CA: The Glenn A. Fry Award Lecture. Early losses of visual function in glaucoma. Optom Vis Sci. 72:359–370. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Ashok A, Kang MH, Wise AS, Pattabiraman P, Johnson WM, Lonigro M, Ravikumar R, Rhee DJ and Singh N: Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma. Sci Rep. 9:130902019. View Article : Google Scholar : PubMed/NCBI

13 

Swamy R, Francis BA, Akil H, Yelenskiy A, Francis BA, Chopra V and Huang A: Clinical results of ab interno trabeculotomy using the trabectome in patients with uveitic glaucoma. Clin Exp Ophthalmol. Sep 10–2019.(Epub ahead of print). doi: 10.1111/ceo.13639. View Article : Google Scholar : PubMed/NCBI

14 

Zhao Y, Zhang F, Pan Z, Luo H, Liu K and Duan X: LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon's capsule fibroblasts. Cell Death Dis. 10:5942019. View Article : Google Scholar : PubMed/NCBI

15 

Congrains A, Kamide K, Ohishi M and Rakugi H: ANRIL: Molecular mechanisms and implications in human health. Int J Mol Sci. 14:1278–1292. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Zhou RM, Wang XQ, Yao J, Shen Y, Chen SN, Yang H, Jiang Q and Yan B: Identification and characterization of proliferative retinopathy-related long noncoding RNAs. Biochem Biophys Res Commun. 465:324–330. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Yao J, Wang XQ, Li YJ, Shan K, Yang H, Wang YN, Yao MD, Liu C, Li XM, Shen Y, et al: Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling. EMBO Mol Med. 8:346–362. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Nakazawa T, Shimura M, Tomita H, Akiyama H, Yoshioka Y, Kudou H and Tamai M: Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury. Curr Eye Res. 26:55–63. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Lee YJ, Ke CY, Tien N and Lin PK: Hyperhomocysteinemia causes chorioretinal angiogenesis with placental growth factor upregulation. Sci Rep. 8:157552018. View Article : Google Scholar : PubMed/NCBI

20 

Midena E, Bini S, Frizziero L, Pilotto E, Esposito G and Micera A: Aqueous humour concentrations of PEDF and Erythropoietin are not influenced by subthreshold micropulse laser treatment of diabetic macular edema. Biosci Rep. 39:392019. View Article : Google Scholar

21 

Benitez-Del-Castillo J, Cantu-Dibildox J, Sanz-González SM, Zanón-Moreno V and Pinazo-Duran MD: Cytokine expression in tears of patients with glaucoma or dry eye disease: A prospective, observational cohort study. Eur J Ophthalmol. 29:437–443. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Aketa N, Yamaguchi T, Suzuki T, Higa K, Yagi-Yaguchi Y, Satake Y, Tsubota K and Shimazaki J: Iris damage is associated with elevated cytokine levels in aqueous humor. Invest Ophthalmol Vis Sci. 58:BIO42–BIO51. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng M, Zheng Y, Gao M, Ma H, Zhang X, Li Y, Wang F and Huang H: Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Exp Ther Med 19: 1329-1335, 2020.
APA
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y. ... Huang, H. (2020). Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Experimental and Therapeutic Medicine, 19, 1329-1335. https://doi.org/10.3892/etm.2019.8345
MLA
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y., Wang, F., Huang, H."Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients". Experimental and Therapeutic Medicine 19.2 (2020): 1329-1335.
Chicago
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y., Wang, F., Huang, H."Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1329-1335. https://doi.org/10.3892/etm.2019.8345
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng M, Zheng Y, Gao M, Ma H, Zhang X, Li Y, Wang F and Huang H: Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Exp Ther Med 19: 1329-1335, 2020.
APA
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y. ... Huang, H. (2020). Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Experimental and Therapeutic Medicine, 19, 1329-1335. https://doi.org/10.3892/etm.2019.8345
MLA
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y., Wang, F., Huang, H."Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients". Experimental and Therapeutic Medicine 19.2 (2020): 1329-1335.
Chicago
Zheng, M., Zheng, Y., Gao, M., Ma, H., Zhang, X., Li, Y., Wang, F., Huang, H."Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1329-1335. https://doi.org/10.3892/etm.2019.8345
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