Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double‑blind study

Hutchins,Elizabeth; Shaikh,Kashif; Kinninger,April; Cherukuri,Lavanya; Birudaraju,Divya; Mao,Song Shou; Nakanishi,Rine; Almeida,Shone; Jayawardena,Eranthi; Shekar,Chandana; Flores,Fredinand; Hamal,Sajad; Sheikh,Salman; Johanis,Amit; Cu,Benedict; Trad,George; Budoff,Matthew J.

doi:10.3892/etm.2019.8373

February-2020 Volume 19 Issue 2

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February-2020 Volume 19 Issue 2

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Article Open Access

Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double‑blind study

Authors:
- Elizabeth Hutchins
- Kashif Shaikh
- April Kinninger
- Lavanya Cherukuri
- Divya Birudaraju
- Song Shou Mao
- Rine Nakanishi
- Shone Almeida
- Eranthi Jayawardena
- Chandana Shekar
- Fredinand Flores
- Sajad Hamal
- Salman Sheikh
- Amit Johanis
- Benedict Cu
- George Trad
- Matthew J. Budoff
View Affiliations / Copyright

Affiliations: Los Angeles Biomedical Institute at Harbor‑UCLA Medical Institute, Torrance, CA 90502, USA

Copyright: © Hutchins et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1468-1471
|
Published online on: December 27, 2019

https://doi.org/10.3892/etm.2019.8373
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Abstract

Increased left ventricular myocardial mass (LVM) is a well known prognostic marker of poor cardiac outcomes. Decreases in LVM have been shown to decrease the cardiovascular risk. Aged garlic extract (AGE) has been shown to have an overall favorable effect on cardiac health; however, to the best of our knowledge, no study to date has specifically examined its effects on left ventricular mass. This study investigated whether AGE can affect LVM measured by cardiac computed tomography angiography (CCTA) in patients with diabetes mellitus (DM). This is a double‑blind, placebo controlled randomized trial. In total, 65 participants with DM with a mean age of 58 years were prospectively assigned to consume 2,400 mg AGE/day or the placebo orally. Both groups underwent CCTA at baseline and follow‑up at 1 year apart. LVM was measured using automated software. The baseline characteristics did not differ between the AGE and placebo groups. There was a trend towards a significant reduction in LVM at follow‑up as compared to baseline in the AGE group (119.30±34.77 vs. 121.0±34.70, P=0.059). No change was observed in LVM in the placebo group at 1‑year follow‑up as compared to baseline (124.6±37.33 vs. 124.6±35.13, P=0.9). On the whole, this study indicated that AGE may decrease or stabilize LVM. Further studies however, with a larger sample size and longer follow‑up times are required to evaluate the effects of AGE on hypertension and LVM.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double‑blind study

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