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Review Open Access

The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review)

  • Authors:
    • Masahiro Ohtani
    • Tsubasa Nishimura
  • View Affiliations / Copyright

    Affiliations: Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata, Hiroshima 739‑1195, Japan
    Copyright: © Ohtani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1507-1510
    |
    Published online on: December 27, 2019
       https://doi.org/10.3892/etm.2019.8382
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Abstract

Since ancient times, pharmacologically active ingredients derived from natural sources, including plants and microbials have been used in the treatment of a wide array of diseases, such as atherosclerosis, diabetes mellitus and cancers. Herbal extracts and polyphenols are produced from herbs that contain a variety of ingredients, most of which exhibit anti‑inflammatory, anti‑oxidative and anti‑microbial actions. Gingivitis is triggered by the infection of the periodontal tissues with periodontal disease‑causing pathogens present in the dental biofilm. This is accompanied by weak inflammatory immune reactions in the gingiva. In periodontitis, prolonged and excessive inflammation results in the destruction of gingival connective tissue and in the resorption of alveolar bone, leading to tooth loss. There are a number of clinical reports showing the effectiveness of both herbal extracts and polyphenols on periodontal diseases when applied as a mouthwash or dentifrice into the oral cavity. However, to date, at least to the best of our knowledge, there is no clinical report available on the therapeutic effects of garlic or its extract on periodontal diseases, apart from a recent study, which reported that the intake of aged garlic extract (AGE) containing various pharmacologically active sulfur compounds, alleviated the symptoms of gingivitis clinically. The finding suggests that AGE may be a promising candidate for use in the treatment of periodontal diseases, although additional clinical trials are warranted to confirm this. In addition, further studies are required for the clarification of the basic molecular mechanisms through which AGE attenuates gingivitis. In this review, we summarize the beneficial effects of several natural compounds on periodontal disease and describe the possible applications of garlic ingredients in detail.
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1 

Pulikkotil SJ and Nath S: Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis. Aust Dent J. 60:317–327. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zini A, Mann J, Mazor S and Vered Y: The efficacy of aged garlic extract on gingivitis-A randomized clinical trial. J Clin Dent. 29:52–56. 2018.PubMed/NCBI

3 

Safiaghdam H, Oveissi V, Bahramsoltani R, Farzaei MH and Rahimi R: Medicinal plants for gingivitis: A review of clinical trials. Iran J Basic Med Sci. 21:978–991. 2018.PubMed/NCBI

4 

Ara T, Nakatani S, Kobata K, Sogawa N and Sogawa C: The biological efficacy of natural products against acute and chronic inflammatory diseases in the oral region. Medicines (Basel). 5:1222018. View Article : Google Scholar

5 

Ramesh A, Varghese SS, Doraiswamy JN and Malaiappan S: Herbs as an antioxidant arsenal for periodontal diseases. J Intercult Ethnopharmacol. 5:92–96. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Benso B, Rosalen PL, Alencar SM and Murata RM: Malva sylvestris inhibits inflammatory response in oral human cells. An in vitro infection model. PLoS One. 10:e01403312015. View Article : Google Scholar : PubMed/NCBI

7 

Wang HH, Lee HM, Raja V, Hou W, Iacono VJ, Scaduto J, Johnson F, Golub LM and Gu Y: Enhanced efficacy of chemically modified curcumin in experimental periodontitis: Systemic implications. J Exp Pharmacol. 11:1–14. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Salvi GE and Lang NP: Host response modulation in the management of periodontal diseases. J Clin Periodontol. 32 (Suppl 6):108–129. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Sağlam M, Köseoğlu S, Hatipoğlu M, Esen HH and Köksal E: Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats. J Appl Oral Sci. 23:33–41. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Tominari T, Matsumoto C, Watanabe K, Hirata M, Grundler FM, Miyaura C and Inada M: Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 5:522–527. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Asahi Y, Noiri Y, Miura J, Maezono H, Yamaguchi M, Yamamoto R, Azakami H, Hayashi M and Ebisu S: Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms. J Appl Microbiol. 116:1164–1171. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Tominari T, Ichimaru R, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Grundler FMW, Inada M and Miyaura C: Effects of O-methylated (−)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice. FEBS Open Bio. 7:1972–1981. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Hrishi T, Kundapur P, Naha A, Thomas B, Kamath S and Bhat G: Effect of adjunctive use of green tea dentifrice in periodontitis patients - A randomized controlled pilot study. Int J Dent Hyg. 14:178–183. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Hirasawa M, Takada K, Makimura M and Otake S: Improvement of periodontal status by green tea catechin using a local delivery system: A clinical pilot study. J Periodontal Res. 37:433–438. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Wu YH, Kuraji R, Taya Y, Ito H and Numabe Y: Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats. J Periodontal Res. 53:1009–1019. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Lombardo Bedran TB, Morin MP, Palomari Spolidorio D and Grenier D: Black tea extract and its theaflavin derivatives inhibit the growth of periodontopathogens and modulate interleukin-8 and beta-defensin secretion in oral epithelial cells. PLoS One. 10:e01431582015. View Article : Google Scholar : PubMed/NCBI

17 

Hosokawa Y, Hosokawa I, Ozaki K, Nakanishi T, Nakae H and Matsuo T: Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts. Mol Nutr Food Res. 54 (Suppl 2):S151–S158. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Nagpal M and Sood S: Role of curcumin in systemic and oral health: An overview. J Nat Sci Biol Med. 4:3–7. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL and Rossa C Jr: Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res. 46:269–279. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Guimarães MR, de Aquino SG, Coimbra LS, Spolidorio LC, Kirkwood KL and Rossa C Jr: Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats. Innate Immun. 18:155–163. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Shetty S, Thomas B, Shetty V, Bhandary R and Shetty RM: An in-vitro evaluation of the efficacy of garlic extract as an antimicrobial agent on periodontal pathogens: A microbiological study. Ayu. 34:445–451. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Tsui PF, Lin CS, Ho LJ and Lai JH: Spices and atherosclerosis. Nutrients. 10:17242018. View Article : Google Scholar

23 

Ried K: Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity. An updated meta-analysis and review. J Nutr. 146:389S–396S. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Moutia M, Habti N and Badou A: In vitro and in vivo immunomodulator activities of Allium sativum L. Evid Based Complement Alternat Med. 2018:49846592018. View Article : Google Scholar : PubMed/NCBI

25 

Bakri IM and Douglas CW: Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol. 50:645–651. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z and Steinberg D: Garlic allicin as a potential agent for controlling oral pathogens. J Med Food. 14:1338–1343. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Velliyagounder K, Ganeshnarayan K, Velusamy SK and Fine DH: In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans. Antimicrob Agents Chemother. 56:2397–2407. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Suzuki JI, Kodera Y, Miki S, Ushijima M, Takashima M, Matsutomo T and Morihara N: Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 8:141482018. View Article : Google Scholar : PubMed/NCBI

29 

Matsumoto S, Nakanishi R, Li D, Alani A, Rezaeian P, Prabhu S, Abraham J, Fahmy MA, Dailing C, Flores F, et al: Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with metabolic syndrome in a prospective randomized double-blind study. J Nutr. 146:427S–432S. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Zeb I, Ahmadi N, Nasir K, Kadakia J, Larijani VN, Flores F, Li D and Budoff MJ: Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc Dis Res. 3:185–190. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ried K, Travica N and Sali A: The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at Heart trial. Integr Blood Press Control. 9:9–21. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Anandasadagopan SK, Sundaramoorthy C, Pandurangan AK, Nagarajan V, Srinivasan K and Ganapasam S: S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats. Hum Exp Toxicol. 36:1186–1200. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Hiramatsu K, Tsuneyoshi T, Ogawa T and Morihara N: Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells. Nutr Res. 36:143–149. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Tsuneyoshi T, Kunimura K and Morihara N: S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 84:22–29. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ohtani M and Nishimura T: The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review). Exp Ther Med 19: 1507-1510, 2020.
APA
Ohtani, M., & Nishimura, T. (2020). The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review). Experimental and Therapeutic Medicine, 19, 1507-1510. https://doi.org/10.3892/etm.2019.8382
MLA
Ohtani, M., Nishimura, T."The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1507-1510.
Chicago
Ohtani, M., Nishimura, T."The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1507-1510. https://doi.org/10.3892/etm.2019.8382
Copy and paste a formatted citation
x
Spandidos Publications style
Ohtani M and Nishimura T: The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review). Exp Ther Med 19: 1507-1510, 2020.
APA
Ohtani, M., & Nishimura, T. (2020). The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review). Experimental and Therapeutic Medicine, 19, 1507-1510. https://doi.org/10.3892/etm.2019.8382
MLA
Ohtani, M., Nishimura, T."The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1507-1510.
Chicago
Ohtani, M., Nishimura, T."The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1507-1510. https://doi.org/10.3892/etm.2019.8382
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