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Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review)

  • Authors:
    • Yusuke Yamaguchi
    • Hitomi Kumagai
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry and Life Science, Nihon University, Fujisawa‑shi 252‑0880, Japan
    Copyright: © Yamaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1528-1535
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    Published online on: December 27, 2019
       https://doi.org/10.3892/etm.2019.8385
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Abstract

S‑Allyl‑l‑cysteine sulfoxide (ACSO) is an odour precursor in garlic bulbs. One plausible pathway for the biosynthesis of ACSO involves S‑2‑carboxypropyl glutathione produced from glutathione and methacrylic acid via valine or from γ‑glutamyl cysteine. The elimination of glycine and glutamic acid from S‑2‑carboxypropyl glutathione produces S‑2‑carboxypropyl cysteine, which is converted to S‑allyl cysteine by decarboxylation and oxidation. S‑Allyl cysteine is also biosynthesized via the elimination of glutamic acid from γ‑glutamyl S‑allyl cysteine by γ‑glutamyl transpeptidase. The sulfur oxidation of S‑allyl cysteine by flavin‑containing monooxygenase forms ACSO. When cells are damaged by slicing or grating, ACSO in the cytoplasm or cytoplasmic vesicle is immediately converted to allylsulfenic acid, pyruvic acid, and ammonia by alliinase (C‑S lyase), which is located in the vacuoles of vascular bundle sheath cells. Two molecules of allylsulfenic acid form diallyl thiosulfinate (allicin), which exhibits potent antimicrobial activity. Allicin eventually yields garlic odour compounds, such as diallyl disulfide (DADS) and diallyl trisulfide (DATS). Although these sulfides are known to exert various physiological functions, their strong odour limits their use in foods. On the other hand, ACSO is water‑soluble and odourless and enhances sweet, salty, and umami tastes, characteristics of which are desirable for food additives. Upon consumption, ACSO is primarily absorbed from the small intestine in the intact form, but is also partly decomposed to allylsulfenic acid, pyruvic acid and ammonia. Allylsulfenic acid is then further converted to DADS and diallyl monosulfide (DAS). ACSO has numerous in vivo functions, such as the prevention of diabetes, myocardial ischaemia, hepatic injury, platelet aggregation and blood ethanol elevation. Although some of these effects may be attributed to its metabolites, ACSO itself contributes to many of these physiological functions.
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1 

Goncagul G and Ayaz E: Antimicrobial effect of garlic (Allium sativum) and traditional medicine. J Anim Vet Adv. 9:1–4. 2010. View Article : Google Scholar

2 

Touloupakis E and Ghanotakis DF: Nutraceutical use of garlic sulfur-containing compounds. Adv Exp Med Biol. 698:110–121. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Rahman MS, Al-Sheibani HI, Al-Riziqi MH, Mothershaw A, Guizani N and Bengtsson G: Assesment of the anti-microbial activity of dried garlic powders produced by different methods of drying. Int J Food Prop. 9:503–513. 2006. View Article : Google Scholar

4 

Durak I, Aytaç B, Atmaca Y, Devrim E, Avci A, Erol C and Oral D: Effects of garlic extract consumption on plasma and erythrocyte antioxidant parameters in atherosclerotic patients. Life Sci. 75:1959–1966. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M and Banerjee SK: Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS One. 9:e942282014. View Article : Google Scholar : PubMed/NCBI

6 

Bongiorno PB, Fratellone PM and LoGiudice P: Potential health benefits of garlic (Allium sativum): A narrative review. J Complement Integr Med. 5:1–26. 2008. View Article : Google Scholar

7 

Rose P, Whiteman M, Moore PK and Zhu YZ: Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: The chemistry of potential therapeutic agents. Nat Prod Rep. 22:351–368. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Zawistowski J, Kopec A, Jedrszczyk E, Francik R and Bystrowska B: Garlic grown from air bulbils and its potential health benefits. ACS Symp Ser. 1286:315–328. 2018. View Article : Google Scholar

9 

Mithen R: Sulphur-containing compounds. Plant secondary metabolites: occurrence, structure and role in the human diet. Crozier A, Clifford N and Ashida H: Blackwell Publishing; Hoboken, NJ: pp. 25–46. 2006, View Article : Google Scholar

10 

Palani S, Joseph NM, Tegene Y and Zacharia A: Medical properties of garlic - A concise review. Curr Res Pharm Sci. 4:92–98. 2014.

11 

Ueda Y, Sakaguchi M, Hirayama K, Miyajima R and Kimizuka A: Characteristic flavor constituents in water extract of garlic. Agric Biol Chem. 54:163–169. 1990. View Article : Google Scholar

12 

Granroth B: Biosynthesis and decomposition of cysteine derivatives in onion and other Allium species. Ann Acad Sci Fenn, Ser A2. Chem. 154:1–71. 1970.

13 

Jones MG, Hughes J, Tregova A, Milne J, Tomsett AB and Collin HA: Biosynthesis of the flavour precursors of onion and garlic. J Exp Bot. 55:1903–1918. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Hughes J, Tregova A, Tomsett AB, Jones MG, Cosstick R and Collin HA: Synthesis of the flavour precursor, alliin, in garlic tissue cultures. Phytochemistry. 66:187–194. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Suzuki T, Sugii M and Kakimoto T: Metabolic incorporation of L-valine-[14C] into S-(2-carboxypropyl) glutathione and S-(2-carboxypropyl) cysteine in garlic. Chem Pharm Bull (Tokyo). 10:328–331. 1962. View Article : Google Scholar : PubMed/NCBI

16 

Lancaster JE and Shaw ML: γ-Glutamyl peptides in the biosynthesis of S-alk(en)yl-L-cysteine sulfoxides (flavor precursors) in Allium. Phytochemistry. 28:455–460. 1989. View Article : Google Scholar

17 

Yoshimoto N, Onuma M, Mizuno S, Sugino Y, Nakabayashi R, Imai S, Tsuneyoshi T, Sumi S and Saito K: Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic. Plant J. 83:941–951. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Yoshimoto N, Yabe A, Sugino Y, Murakami S, Sai-Ngam N, Sumi S, Tsuneyoshi T and Saito K: Garlic γ-glutamyl transpeptidases that catalyze deglutamylation of biosynthetic intermediate of alliin. Front Plant Sci. 5:7582015. View Article : Google Scholar : PubMed/NCBI

19 

Suzuki T, Sugii M, Kakimoto T and Tsuboi N: Isolation of (−)-S-allyl-L-cysteine from garlic. Chem Pharm Bull (Tokyo). 9:251–252. 1961. View Article : Google Scholar

20 

Ziegler SJ and Sticher O: HPLC of S-alk(en)yl-L-cysteine derivatives in garlic including quantitative determination of (+)-S-allyl-L-cysteine sulfoxide (alliin). Planta Med. 55:372–378. 1989. View Article : Google Scholar : PubMed/NCBI

21 

Lawson LD, Wang Z-Y and Hughes BG: γ-Glutamyl-S-alkylcysteines in garlic and other Allium spp.: Precursors of age-dependent trans−1-propenyl thiosulfinates. J Nat Prod. 54:436–444. 1991. View Article : Google Scholar

22 

Farooqui AA and Farooqui T: Garlic and its effects in neurological disorders. Neuroprotective effects of phytochemicals in neurological disorders. John Wiley & Sons; Hoboken, NJ: pp. 113–131. 2017, View Article : Google Scholar

23 

Hirata S, Abdelrahman M, Yamauchi N and Shigyo M: Characteristics of chemical components in genetic resources of garlic Allium sativum collected from all over the world. Genet Resour Crop Evol. 63:35–45. 2016. View Article : Google Scholar

24 

Lawson LD: Garlic: A review of its medicinal effects and indicated active compounds. ACS Symp Ser. 691:176–209. 1998. View Article : Google Scholar

25 

Ueda Y, Kawajiri H, Miyamura N and Miyajima R: Content of some sulfur-containing components and free amino acids in various strains of garlic. Nippon Shokuhin Kogyo Gakkaishi (J Jpn Soc Food Sci Technol). 38:429–434. 1991. View Article : Google Scholar

26 

Mütsch-Eckner M, Sticher O and Meier B: Reversed-phase high-performance liquid chromatography of S-alk(en)yl-L-cysteine derivatives in Allium sativum including the determination of (+)-S-allyl-L-cysteine sulphoxide, γ-L-glutamyl-S-allyl-L-cysteine and γ-L-glutamyl-S-(trans−1-propenyl)-L-cysteine. J Chromatogr A. 625:183–190. 1992. View Article : Google Scholar

27 

Bloem E, Haneklaus S and Schnug E: Storage life of field-grown garlic bulbs (Allium sativum L.) as influenced by nitrogen and sulfur fertilization. J Agric Food Chem. 59:4442–4447. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yamazaki Y and Okuno T: Accumulation of S-allyl-L-cysteine in garlic bulbs by warming. Nippon Shokuhin Kagaku Kogaku Kaishi. 55:410–415. 2008. View Article : Google Scholar

29 

Rahman MS: Allicin and other functional active components in garlic: Health benefits and bioavailability. Int J Food Prop. 10:245–268. 2007. View Article : Google Scholar

30 

Martins N, Petropoulos S and Ferreira ICFR: Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review. Food Chem. 211:41–50. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Matsuura H, Inagaki M, Maeshige K, Ide N, Kajimura Y and Itakura Y: Changes in contents of γ-glutamyl peptides and fructan during growth of Allium sativum. Planta Med. 62:70–71. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Ellmore GS and Feldberg RS: Allin lyase localization in bundle sheaths of the garlic clove (Allium sativum). Am J Bot. 81:89–94. 1994. View Article : Google Scholar

33 

Penn RE, Block E and Revelle LK: Flash vacuum pyrolysis studies. 5. Methanesulfenic acid. J Am Chem Soc. 100:3622–3623. 1978. View Article : Google Scholar

34 

Cavallito CJ, Buck JS and Suter CM: Allicin, the antibacterial principle of Allium sativum. II. Determination of the chemical structure. J Am Chem Soc. 66:1952–1954. 1944. View Article : Google Scholar

35 

Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID and Slusarenko AJ: Allicin: Chemistry and biological properties. Molecules. 19:12591–12618. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Choi MK: CHae K-Y, Lee J-Y and Kyung KH: Antimicrobial activity of chemical substances derived from S-alk(en)yl-L-cysteine sulfoxide (alliin) in garlic, Allium sativum L. Food Sci Biotechnol. 16:1–7. 2007.

37 

Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D and Weiner L: The mode of action of allicin: Trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1379:233–244. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Lawson LD, Wang ZJ and Hughes BG: Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med. 57:363–370. 1991. View Article : Google Scholar : PubMed/NCBI

39 

Singh VK and Singh DK: Pharmacological effects of garlic (Allium sativum L.). Ann Rev Biomed Sci. 10:6–26. 2008.

40 

Block E, Naganathan S, Putman D and Zhao SH: Allium chemistry: HPLC analysis of thiosulfinates from onion, garlic, wild garlic (ramsoms), leek, scallion, shallot, elephant (great-headed) garlic, chive, and Chinese chive. Uniquely high allyl to methyl ratios in some garlic samples. J Agric Food Chem. 40:2418–2430. 1992. View Article : Google Scholar

41 

Yamaguchi Y, Honma R, Yazaki T, Shibuya T, Sakaguchi T, Uto-Kondo H and Kumagai H: Sulfuric odor precursor S-allyl-L-cysteine sulfoxide in garlic induces detoxifying enzymes and prevents hepatic injury. Antioxidants. 8:3852019. View Article : Google Scholar

42 

Bartzatt R, Blum D and Nagel D: Isolation of Garlic Derived Sulfur Compounds from Urine. Anal Lett. 25:1217–1224. 1992. View Article : Google Scholar

43 

de Rooij BM, Boogaard PJ, Rijksen DA, Commandeur JN and Vermeulen NP: Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers. Arch Toxicol. 70:635–639. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Jandke J and Spiteller G: Unusual conjugates in biological profiles originating from consumption of onions and garlic. J Chromatogr A. 421:1–8. 1987. View Article : Google Scholar

45 

Trio PZ, You S, He X, He J, Sakao K and Hou D-X: Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food Funct. 5:833–844. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Verhagen H, Hageman GJ, Rauma A-L, Versluis-de Haan G, van Herwijnen MHM, de Groot J, Törrönen R and Mykkänen H: Biomonitoring the intake of garlic via urinary excretion of allyl mercapturic acid. Br J Nutr. 86 (Suppl 1):S111–S114. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Augusti KT and Sheela CG: Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia. 52:115–120. 1996. View Article : Google Scholar : PubMed/NCBI

48 

Zhai B, Zhang C, Sheng Y, Zhao C, He X, Xu W, Huang K and Luo Y: Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice. Sci Rep. 8:35272018. View Article : Google Scholar : PubMed/NCBI

49 

Sangeetha T and Darlin Quine S: Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: A histopathological study. Mol Cell Biochem. 328:1–8. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Nishimura H and Ariga T: Vinyldithiins in garlic and Japanese domestic Allium (A. victorialis). CS Symp Ser. 546:128–143. 1993.

51 

Akao M, Shibuya T, Shimada S, Sakurai H and Kumagai H: In vivo production of bioactive compounds from S-allyl-L-cysteine sulfoxide, garlic odor precursor, that inhibit platelet aggregation. J Clin Biochem Nutr. (Suppl 43):1–3. 2008.

52 

Uto-Kondo H, Hase A, Yamaguchi Y, Sakurai A, Akao M, Saito T and Kumagai H: S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut. Biosci Biotechnol Biochem. 82:724–731. 2018. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Yamaguchi Y and Kumagai H: Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review). Exp Ther Med 19: 1528-1535, 2020.
APA
Yamaguchi, Y., & Kumagai, H. (2020). Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review). Experimental and Therapeutic Medicine, 19, 1528-1535. https://doi.org/10.3892/etm.2019.8385
MLA
Yamaguchi, Y., Kumagai, H."Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1528-1535.
Chicago
Yamaguchi, Y., Kumagai, H."Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1528-1535. https://doi.org/10.3892/etm.2019.8385
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi Y and Kumagai H: Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review). Exp Ther Med 19: 1528-1535, 2020.
APA
Yamaguchi, Y., & Kumagai, H. (2020). Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review). Experimental and Therapeutic Medicine, 19, 1528-1535. https://doi.org/10.3892/etm.2019.8385
MLA
Yamaguchi, Y., Kumagai, H."Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1528-1535.
Chicago
Yamaguchi, Y., Kumagai, H."Characteristics, biosynthesis, decomposition, metabolism and functions of the garlic odour precursor, S‑allyl‑l‑cysteine sulfoxide (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1528-1535. https://doi.org/10.3892/etm.2019.8385
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