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Review Open Access

Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)

  • Authors:
    • Hailong Song
    • Jiankun Cui
    • Valeri V. Mossine
    • C. Michael Greenlief
    • Kevin Fritsche
    • Grace Y. Sun
    • Zezong Gu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA, Department of Biochemistry, University of Missouri School of Medicine, Columbia, MO 65212, USA, Department of Chemistry, University of Missouri, Columbia, MO 65211, USA, Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1554-1559
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    Published online on: December 27, 2019
       https://doi.org/10.3892/etm.2019.8389
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Abstract

Garlic (Allium sativum) has been widely used for culinary and medicinal purposes. Aged garlic extract (AGE) and sulfur‑containing compounds, including S‑allylcysteine (SAC) are well documented botanical active components of garlic. AGE is prepared by the prolonged extraction of fresh garlic with aqueous ethanol and is considered a nutritional supplement with potential to promote human health. SAC is a water‑soluble organosulfur compound and the most abundant component of AGE. Studies have demonstrated that both AGE and SAC can exert neuroprotective effects against neuroinflammation and neurodegeneration. Another bioactive component in AGE is N‑α‑(1‑deoxy‑D‑fructos‑1‑yl)‑L‑arginine (FruArg) although less is known about the metabolic activity of this compound. The main aim of this review was to provide an undated overview of the neuroprotective perspectives of these active garlic components (AGE, SAC and FruArg). Of interest, our studies and those of others indicate that both AGE and FruArg are involved in the regulation of gene transcription and protein expression. AGE has been shown to reverse 67% of the transcriptome alteration induced by endotoxins‑lipopolysaccharide (LPS), and FruArg has been shown to account for the protective effects by reversing 55% of genes altered in a cell‑based neuroinflammation paradigm stimulated by LPS in murine BV‑2 microglial cells. AGE and FruArg can alleviate neuroinflammatory responses through a variety of signaling pathways, such as Toll‑like receptor and interleukin (IL)‑6 signaling, as well as by upregulating the nuclear factor erythroid 2‑related factor 2 (Nrf2)‑mediated oxidative stress pathways known to promote microglial resiliency against neuroinflammation and neurodegeneration. The capability of FruArg to pass through the blood‑brain barrier further supports its potential as a therapeutic compound. In summary, these experimental results provide new insight into the understanding of the neuroprotective effects of garlic components in promoting brain resiliency for health benefits.
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1 

Chung LY: The antioxidant properties of garlic compounds: Allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food. 9:205–213. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Heber D: The stinking rose: Organosulfur compounds and cancer. Am J Clin Nutr. 66:425–426. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Borek C: Antioxidant health effects of aged garlic extract. J Nutr. 131 (Suppl 3):1010S–1015S. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Kyo E, Uda N, Kasuga S and Itakura Y: Immunomodulatory effects of aged garlic extract. J Nutr. 131 (Suppl 3):1075S–1079S. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Morihara N, Hayama M and Fujii H: Aged garlic extract scavenges superoxide radicals. Plant Foods Hum Nutr. 66:17–21. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Borek C: Garlic reduces dementia and heart-disease risk. J Nutr. 136 (Suppl 3):810S–812S. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Mathew B and Biju R: Neuroprotective effects of garlic a review. Libyan J Med. 3:23–33. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Katsuki T, Hirata K, Ishikawa H, Matsuura N, Sumi S and Itoh H: Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. J Nutr. 136 (Suppl 3):847S–851S. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Tanaka S, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H and Chayama K: Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr. 136 (Suppl 3):821S–826S. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Varshney R and Budoff MJ: Garlic and Heart Disease. J Nutr. 146:416S–421S. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Matsumoto S, Nakanishi R, Li D, Alani A, Rezaeian P, Prabhu S, Abraham J, Fahmy MA, Dailing C, Flores F, et al: Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with metabolic syndrome in a prospective randomized double-blind study. J Nutr. 146:427S–432S. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Ried K, Travica N and Sali A: The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at Heart trial. Integr Blood Press Control. 9:9–21. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Zarezadeh M, Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S and Roghani M: Garlic active constituent s-allyl cysteine protects against lipopolysaccharide-induced cognitive deficits in the rat: Possible involved mechanisms. Eur J Pharmacol. 795:13–21. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Qu Z, Mossine VV, Cui J, Sun GY and Gu Z: Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Neuromolecular Med. 18:474–482. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Finot P: The Maillard reaction in food processing, human nutrition and physiology. Birkäuser Verlag; Basel, Switzerland: 1990, View Article : Google Scholar : PubMed/NCBI

16 

Martins SI, Jongen WM and Van Boekel MA: A review of Maillard reaction in food and implications to kinetic modelling. Trends Food Sci Technol. 11:364–373. 2000. View Article : Google Scholar

17 

Yukinaga M, Yinan Z, Takeshi T, Kenji K and Hiromichi O: Isolation and Physiological Activites of a New Amino Acid Derivative from Korean Red Ginseng. J Ginseng Res. 18:204–211. 1994.

18 

Kitao T, Kon K, Nojima K, Takaku T, Maeda N and Okuda H: Effect of components in non-saponin fraction of red ginseng on microcirculation. J Tradit Med (Toyama). 12:294–295. 1995.

19 

Ide N, Lau BH, Ryu K, Matsuura H and Itakura Y: Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr Biochem. 10:372–376. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Zhou H, Qu Z, Mossine VV, Nknolise DL, Li J, Chen Z, Cheng J, Greenlief CM, Mawhinney TP, Brown PN, et al: Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells. PLoS One. 9:e1135312014. View Article : Google Scholar : PubMed/NCBI

21 

Song H, Lu Y, Qu Z, Mossine VV, Martin MB, Hou J, Cui J, Peculis BA, Mawhinney TP, Cheng J, et al: Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells. Sci Rep. 6:353232016. View Article : Google Scholar : PubMed/NCBI

22 

Johnson MC, Song H, Cui J, Mossine VV, Gu Z and Greenlief CM: Development of a Method and Validation for the Quantitation of FruArg in Mice Plasma and Brain Tissue Using UPLC-MS/MS. ACS Omega. 1:663–668. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Ryu K, Ide N, Matsuura H and Itakura Y: N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J Nutr. 131 (Suppl 3):972S–976S. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Selassie M, Griffin B, Gwebu N and Gwebu ET: Aged garlic extract attenuates the cytotoxicity of beta-amyloid on undifferentiated PC12 cells. In Vitro Cell Dev Biol Anim. 35:369–370. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Peng Q, Buz'Zard AR and Lau BH: Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro. Med Sci Monit. 8:BR328–BR337. 2002.PubMed/NCBI

26 

Chauhan NB: Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. J Ethnopharmacol. 108:385–394. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Jackson R, McNeil B, Taylor C, Holl G, Ruff D and Gwebu ET: Effect of aged garlic extract on caspase-3 activity, in vitro. Nutr Neurosci. 5:287–290. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Marín N, Romero B, Bosch-Morell F, Llansola M, Felipo V, Romá J and Romero FJ: Beta-amyloid-induced activation of caspase-3 in primary cultures of rat neurons. Mech Ageing Dev. 119:63–67. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Ray B, Chauhan NB and Lahiri DK: Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. J Neurochem. 117:388–402. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Nillert N, Pannangrong W, Welbat JU, Chaijaroonkhanarak W, Sripanidkulchai K and Sripanidkulchai B: Neuroprotective effects of aged garlic extract on cognitive dysfunction and neuroinflammation induced by β-amyloid in rats. Nutrients. 9:92017. View Article : Google Scholar

31 

Thorajak P, Pannangrong W, Welbat JU, Chaijaroonkhanarak W, Sripanidkulchai K and Sripanidkulchai B: effects of aged garlic extract on cholinergic, glutamatergic and GABAergic systems with regard to cognitive impairment in Aβ-induced rats. Nutrients. 9:92017. View Article : Google Scholar

32 

Gelders G, Baekelandt V and Van der Perren A: Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease. J Immunol Res. 2018:47842682018. View Article : Google Scholar : PubMed/NCBI

33 

Ransohoff RM: How neuroinflammation contributes to neurodegeneration. Science. 353:777–783. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Graeber MB and Streit WJ: Microglia: Biology and pathology. Acta Neuropathol. 119:89–105. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Block ML, Zecca L and Hong JS: Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat Rev Neurosci. 8:57–69. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Sun AY, Wang Q, Simonyi A and Sun GY: Botanical phenolics and brain health. Neuromolecular Med. 10:259–274. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A and Maldonado PD: The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxid Med Cell Longev. 2012:9071622012. View Article : Google Scholar : PubMed/NCBI

38 

Ray B, Chauhan NB and Lahiri DK: The ‘aged garlic extract’: (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD). Curr Med Chem. 18:3306–3313. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Takechi R, Pallebage-Gamarallage MM, Lam V, Giles C and Mamo JC: Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood-brain barrier function in wild-type mice. J Neuroinflammation. 10:732013. View Article : Google Scholar : PubMed/NCBI

40 

Hiramatsu K, Tsuneyoshi T, Ogawa T and Morihara N: Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells. Nutr Res. 36:143–149. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Kosuge Y, Koen Y, Ishige K, Minami K, Urasawa H, Saito H and Ito Y: S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death. Neuroscience. 122:885–895. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Ide N and Lau BH: Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine. 6:125–131. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Ide N and Lau BH: Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 131 (Suppl 3):1020S–1026S. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Dillon SA, Burmi RS, Lowe GM, Billington D and Rahman K: Antioxidant properties of aged garlic extract: An in vitro study incorporating human low density lipoprotein. Life Sci. 72:1583–1594. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Thomson M, Al-Qattan KK, Js D and Ali M: Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 16:172016. View Article : Google Scholar : PubMed/NCBI

46 

Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA and Stella AM: Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity. Nat Rev Neurosci. 8:766–775. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Pacher P, Beckman JS and Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 87:315–424. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Raichle ME and Snyder AZ: A default mode of brain function: A brief history of an evolving idea. Neuroimage. 37:1083–1090; discussion 1097–1099. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Giasson BI, Ischiropoulos H, Lee VM and Trojanowski JQ: The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med. 32:1264–1275. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Danielson SR and Andersen JK: Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med. 44:1787–1794. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Besson VC, Croci N, Boulu RG, Plotkine M and Marchand-Verrecchia C: Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat. Brain Res. 989:58–66. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Besson VC: Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation. Br J Pharmacol. 157:695–704. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Chauhan NB and Mehla J: Ameliorative Effects of Nutraceuticals in Neurological Disorders. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Watson RR and Preedy VR: Academic Press; San Diego, CA: pp. 245–260. 2015, View Article : Google Scholar

54 

Gupta VB and Rao KS: Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Neurosci Lett. 429:75–80. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Rojas P, Serrano-García N, Medina-Campos ON, Pedraza-Chaverri J, Maldonado PD and Ruiz-Sánchez E: S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. J Nutr Biochem. 22:937–944. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, Ghasemi Z and Roghani M: S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. Eur J Pharmacol. 794:69–76. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Shi H, Jing X, Wei X, Perez RG, Ren M, Zhang X and Lou H: S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo. J Neurochem. 133:298–308. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Zeinali H, Baluchnejadmojarad T, Fallah S, Sedighi M, Moradi N and Roghani M: S-allyl cysteine improves clinical and neuropathological features of experimental autoimmune encephalomyelitis in C57BL/6 mice. Biomed Pharmacother. 97:557–563. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Behera J, Kelly KE and Tyagi N: Altered Non-Coding RNA-Histone Acetylation Regulatory Circuit Is Associated With Cognitive Impairment via Gut Dysbiosis in Aging Mice. The FASEB J. 33:714.32019.

60 

Ohnishi ST and Ohnishi T: In vitro effects of aged garlic extract and other nutritional supplements on sickle erythrocytes. J Nutr. 131 (Suppl 3):1085S–1092S. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Mossine VV, Chopra P and Mawhinney TP: Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Res. 68:4384–4391. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Banks WA: From blood-brain barrier to blood-brain interface: New opportunities for CNS drug delivery. Nat Rev Drug Discov. 15:275–292. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song H, Cui J, Mossine VV, Greenlief CM, Fritsche K, Sun GY and Gu Z: Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review). Exp Ther Med 19: 1554-1559, 2020.
APA
Song, H., Cui, J., Mossine, V.V., Greenlief, C.M., Fritsche, K., Sun, G.Y., & Gu, Z. (2020). Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review). Experimental and Therapeutic Medicine, 19, 1554-1559. https://doi.org/10.3892/etm.2019.8389
MLA
Song, H., Cui, J., Mossine, V. V., Greenlief, C. M., Fritsche, K., Sun, G. Y., Gu, Z."Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1554-1559.
Chicago
Song, H., Cui, J., Mossine, V. V., Greenlief, C. M., Fritsche, K., Sun, G. Y., Gu, Z."Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1554-1559. https://doi.org/10.3892/etm.2019.8389
Copy and paste a formatted citation
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Spandidos Publications style
Song H, Cui J, Mossine VV, Greenlief CM, Fritsche K, Sun GY and Gu Z: Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review). Exp Ther Med 19: 1554-1559, 2020.
APA
Song, H., Cui, J., Mossine, V.V., Greenlief, C.M., Fritsche, K., Sun, G.Y., & Gu, Z. (2020). Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review). Experimental and Therapeutic Medicine, 19, 1554-1559. https://doi.org/10.3892/etm.2019.8389
MLA
Song, H., Cui, J., Mossine, V. V., Greenlief, C. M., Fritsche, K., Sun, G. Y., Gu, Z."Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 1554-1559.
Chicago
Song, H., Cui, J., Mossine, V. V., Greenlief, C. M., Fritsche, K., Sun, G. Y., Gu, Z."Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1554-1559. https://doi.org/10.3892/etm.2019.8389
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