|
1
|
Liang QH, Jiang Y, Zhu X, Cui RR, Liu GY,
Liu Y, Wu SS, Liao XB, Xie H, Zhou HD, et al: Ghrelin attenuates
the osteoblastic differentiation of vascular smooth muscle cells
through the ERK pathway. PLoS One. 7:e331262012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Kojima M, Hosoda H, Date Y, Nakazato M,
Matsuo H and Kangawa K: Ghrelin is a growth-hormone-releasing
acylated peptide from stomach. Nature. 402:656–660. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wang L, Chen Q, Ke D and Li G: Ghrelin
inhibits atherosclerotic plaque angiogenesis and promotes plaque
stability in a rabbit atherosclerotic model. Peptides. 90:17–26.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Lin TC and Hsiao M: Ghrelin and cancer
progression. Biochim Biophys Acta Rev Cancer. 1868:51–57. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Chopin L, Walpole C, Seim I, Cunningham P,
Murray R, Whiteside E, Josh P and Herington A: Ghrelin and cancer.
Mol Cell Endocrinol. 340:65–69. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Waseem T, Javaid-Ur-Rehman, Ahmad F, Azam
M and Qureshi MA: Role of ghrelin axis in colorectal cancer: A
novel association. Peptides. 29:1369–1376. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Jeffery PL, Herington AC and Chopin LK:
Expression and action of the growth hormone releasing peptide
ghrelin and its receptor in prostate cancer cell lines. J
Endocrinol. 172:R7–R11. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Yeh AH, Jeffery PL, Duncan RP, Herington
AC and Chopin LK: Ghrelin and a novel preproghrelin isoform are
highly expressed in prostate cancer and ghrelin activates
mitogen-activated protein kinase in prostate cancer. Clin Cancer
Res. 11:8295–8303. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Díaz-Lezama N, Hernández-Elvira M,
Sandoval A, Monroy A, Felix R and Monjaraz E: Ghrelin inhibits
proliferation and increases T-type Ca2+ channel expression in PC-3
human prostate carcinoma cells. Biochem Biophys Res Commun.
403:24–29. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Bustin SA and Jenkins PJ: The growth
hormone-insulin-like growth factor-I axis and colorectal cancer.
Trends Mol Med. 7:447–454. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Duxbury MS, Waseem T, Ito H, Robinson MK,
Zinner MJ, Ashley SW and Whang EE: Ghrelin promotes pancreatic
adenocarcinoma cellular proliferation and invasiveness. Biochem
Biophys Res Commun. 309:464–468. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Huang C, Zheng H, He W, Lu G, Li X, Deng Y
and Zeng M: Ghrelin ameliorates the human alveolar epithelial A549
cell apoptosis induced by lipopolysaccharide. Biochem Biophys Res
Commun. 474:83–90. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ghè C, Cassoni P, Catapano F, Marrocco T,
Deghenghi R, Ghigo E, Muccioli G and Papotti M: The
antiproliferative effect of synthetic peptidyl GH secretagogues in
human CALU-1 lung carcinoma cells. Endocrinology. 143:484–491.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Bonfili L, Cuccioloni M, Cecarini V,
Mozzicafreddo M, Palermo FA, Cocci P, Angeletti M and Eleuteri AM:
Ghrelin induces apoptosis in colon adenocarcinoma cells via
proteasome inhibition and autophagy induction. Apoptosis.
18:1188–1200. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Jeffery PL, Murray RE, Yeh AH, McNamara
JF, Duncan RP, Francis GD, Herington AC and Chopin LK: Expression
and function of the ghrelin axis, including a novel preproghrelin
isoform, in human breast cancer tissues and cell lines. Endocr
Relat Cancer. 12:839–850. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Grönberg M, Ahlin C, Naeser Y, Janson ET,
Holmberg L and Fjällskog ML: Ghrelin is a prognostic marker and a
potential therapeutic target in breast cancer. PLoS One.
12:e01760592017. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Cassoni P, Papotti M, Ghè C, Catapano F,
Sapino A, Graziani A, Deghenghi R, Reissmann T, Ghigo E and
Muccioli G: Identification, characterization, and biological
activity of specific receptors for natural (ghrelin) and synthetic
growth hormone secretagogues and analogs in human breast carcinomas
and cell lines. J Clin Endocrinol Metab. 86:1738–1745. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Rak-Mardyla A and Gregoraszczuk EL: ERK
1/2 and PI-3 kinase pathways as a potential mechanism of ghrelin
action on cell proliferation and apoptosis in the porcine ovarian
follicular cells. J Physiol Pharmacol. 61:451–458. 2010.PubMed/NCBI
|
|
19
|
Wang D, Chen J, Chen H, Duan Z, Xu Q, Wei
M, Wang L and Zhong M: Leptin regulates proliferation and apoptosis
of colorectal carcinoma through PI3K/Akt/mTOR signaling pathway. J
Biosci. 37:91–101. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Sever S, White DL and Garcia JM: Is there
an effect of ghrelin/ghrelin analogs on cancer? A systematic
review. Endocr Relat Cancer. 23:R393–R409. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Györffy B and Schäfer R: Meta-analysis of
gene expression profiles related to relapse-free survival in 1,079
breast cancer patients. Breast Cancer Res Treat. 118:433–441. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Barzon L, Pacenti M, Masi G, Stefani AL,
Fincati K and Palù G: Loss of growth hormone secretagogue receptor
1a and overexpression of type 1b receptor transcripts in human
adrenocortical tumors. Oncology. 68:414–421. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zhu J, Yao J, Huang R, Wang Y, Jia M and
Huang Y: Ghrelin promotes human non-small cell lung cancer A549
cell proliferation through PI3K/Akt/mTOR/P70S6K and ERK signaling
pathways. Biochem Biophys Res Commun. 498:616–620. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Lien GS, Lin CH, Yang YL, Wu MS and Chen
BC: Ghrelin induces colon cancer cell proliferation through the
GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways. Eur J
Pharmacol. 776:124–131. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yang D, Liu Z, Zhang H and Luo Q: Ghrelin
inhibits human pulmonary artery endothelial cells against
hypoxia-induced injury via PI3-kinase/Akt. Peptides. 42:112–117.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Zhu J, Zheng C, Chen J, Luo J, Su B, Huang
Y, Su W, Li Z and Cui T: Ghrelin inhibits human umbilical vein
endothelial cells against high glucose-induced apoptosis via
mTOR/P70S6K signaling pathway. Peptides. 52:23–28. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Liu S, Chen S, Ren J, Li B and Qin B:
Ghrelin inhibits retinal ganglion cells against rotenone via
inhibiting apoptosis, restoring mitochondrial function, and
activating AKT-mTOR signaling. Neuropeptides. 67:63–70. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N
and Zhang J: Ghrelin protects against dexamethasone-induced INS-1
cell apoptosis via ERK and p38MAPK signaling. Int J Endocrinol.
2016:45130512016. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Korbonits M, Bustin SA, Kojima M, Jordan
S, Adams EF, Lowe DG, Kangawa K and Grossman AB: The expression of
the growth hormone secretagogue receptor ligand ghrelin in normal
and abnormal human pituitary and other neuroendocrine tumors. J
Clin Endocrinol Metab. 86:881–887. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lin TC, Liu YP, Chan YC, Su CY, Lin YF,
Hsu SL, Yang CS and Hsiao M: Ghrelin promotes renal cell carcinoma
metastasis via snail activation and is associated with poor
prognosis. J Pathol. 237:50–61. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Bai RX, Wang WP, Zhao PW and Li CB:
Ghrelin attenuates the growth of HO-8910 ovarian cancer cells
through the ERK pathway. Braz J Med Biol Res. 49(pii):
S0100-879X2016000300602. 2016.
|
