Open Access

Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report

  • Authors:
    • Kanta Hori
    • Yoshihiko Hirohashi
    • Toshiki Aoyagi
    • Narumi Taniguchi
    • Masashi Murakumo
    • Haruka Miyata
    • Toshihiko Torigoe
    • Takashige Abe
    • Nobuo Shinohara
    • Ken Morita
  • View Affiliations

  • Published online on: January 3, 2020     https://doi.org/10.3892/etm.2020.8423
  • Pages: 1903-1907
  • Copyright: © Hori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The case of a patient with metastatic renal cell carcinoma who exhibited the abscopal effect following treatment by anti‑programmed death‑1 (PD‑1) antibody is presented. A 40‑year‑old woman was diagnosed with an 8.2‑cm renal tumor without distant metastases, and radical nephrectomy was subsequently performed. Pathological examination revealed a clear cell renal cell carcinoma. At 3 months after surgery, the patient developed one lung metastasis. Following treatment with interferon and three types of tyrosine kinase inhibitors, anti‑PD1 antibody (nivolumab) was started. During the treatment, para‑aortic/supraclavicular lymph nodes and several lung lesions remained, although other lesions decreased markedly. The patient was subsequently treated by palliative radiotherapy to the para‑aortic and supraclavicular lymph nodes for pain control. After the radiotherapy, the lung lesions previously refractory to nivolumab started to decrease, probably due to an abscopal effect. Additionally, the laboratory data and Karnofsky Performance Status improved. Histological re‑examination of the primary lesion revealed heterogeneity of the immunological microenvironment, which may be associated with the heterogeneity of treatment sensitivity.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Hori, K., Hirohashi, Y., Aoyagi, T., Taniguchi, N., Murakumo, M., Miyata, H. ... Morita, K. (2020). Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report. Experimental and Therapeutic Medicine, 19, 1903-1907. https://doi.org/10.3892/etm.2020.8423
MLA
Hori, K., Hirohashi, Y., Aoyagi, T., Taniguchi, N., Murakumo, M., Miyata, H., Torigoe, T., Abe, T., Shinohara, N., Morita, K."Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report". Experimental and Therapeutic Medicine 19.3 (2020): 1903-1907.
Chicago
Hori, K., Hirohashi, Y., Aoyagi, T., Taniguchi, N., Murakumo, M., Miyata, H., Torigoe, T., Abe, T., Shinohara, N., Morita, K."Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1903-1907. https://doi.org/10.3892/etm.2020.8423