Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report

Hori,Kanta; Hirohashi,Yoshihiko; Aoyagi,Toshiki; Taniguchi,Narumi; Murakumo,Masashi; Miyata,Haruka; Torigoe,Toshihiko; Abe,Takashige; Shinohara,Nobuo; Morita,Ken

doi:10.3892/etm.2020.8423

March-2020 Volume 19 Issue 3

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March-2020 Volume 19 Issue 3

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Case Report Open Access

Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report

Authors:
- Kanta Hori
- Yoshihiko Hirohashi
- Toshiki Aoyagi
- Narumi Taniguchi
- Masashi Murakumo
- Haruka Miyata
- Toshihiko Torigoe
- Takashige Abe
- Nobuo Shinohara
- Ken Morita
View Affiliations / Copyright

Affiliations: Department of Urology, Kushiro City General Hospital, Kushiro 085‑0822, Japan, Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060‑8556, Japan, Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060‑8648, Japan

Copyright: © Hori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1903-1907
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Published online on: January 3, 2020

https://doi.org/10.3892/etm.2020.8423
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Abstract

The case of a patient with metastatic renal cell carcinoma who exhibited the abscopal effect following treatment by anti‑programmed death‑1 (PD‑1) antibody is presented. A 40‑year‑old woman was diagnosed with an 8.2‑cm renal tumor without distant metastases, and radical nephrectomy was subsequently performed. Pathological examination revealed a clear cell renal cell carcinoma. At 3 months after surgery, the patient developed one lung metastasis. Following treatment with interferon and three types of tyrosine kinase inhibitors, anti‑PD1 antibody (nivolumab) was started. During the treatment, para‑aortic/supraclavicular lymph nodes and several lung lesions remained, although other lesions decreased markedly. The patient was subsequently treated by palliative radiotherapy to the para‑aortic and supraclavicular lymph nodes for pain control. After the radiotherapy, the lung lesions previously refractory to nivolumab started to decrease, probably due to an abscopal effect. Additionally, the laboratory data and Karnofsky Performance Status improved. Histological re‑examination of the primary lesion revealed heterogeneity of the immunological microenvironment, which may be associated with the heterogeneity of treatment sensitivity.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma‑unique pathological features of the primary specimen: A case report

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