Characteristics of culprit lesions in young patients with metabolic syndrome and classic cardiovascular risk factors

  • Authors:
    • Fangjie Hou
    • Yujie Zhou
    • Wei Liu
    • Shiwei Yang
    • Zhijian Wang
    • Xiaoteng Ma
    • Yu Du
    • Ya Li
    • Jun Guan
  • View Affiliations

  • Published online on: February 3, 2020     https://doi.org/10.3892/etm.2020.8484
  • Pages: 2766-2772
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Abstract

The association between cardiovascular risk factors (CVRFs) and characteristics of coronary plaque in young patients has remained to be fully elucidated. Therefore, the present study sought to determine the association between CVRFs and phenotypes of culprit coronary plaques revealed by optical coherence tomography (OCT) in young patients with stable coronary heart disease (CHD) and acute coronary syndrome (ACS). OCT imaging pullback was performed at corresponding sites on 123 lesions in 123 young patients (age, 36±7 years), including those with stable CHD and ACS. Patients with analyzable OCT images were classified as having thin‑cap fibroatheromas (TCFAs), plaque rupture, macrophage accumulation, calcified nodule, vasa vasorum, cholesterol crystal and erosion. TCFAs were more prevalent in patients with metabolic syndrome (MetS) than in those without MetS (P=0.020). Plaque rupture was more common in smokers than in non‑smokers (P=0.002). Multivariate analysis indicated that MetS was independently associated with TCFAs (P=0.041) and smoking was independently associated with plaque rupture (P=0.006). Young patients with MetS were demonstrated to have more extensive TCFAs and young smokers had a higher prevalence of culprit plaque rupture.
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April-2020
Volume 19 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hou F, Zhou Y, Liu W, Yang S, Wang Z, Ma X, Du Y, Li Y and Guan J: Characteristics of culprit lesions in young patients with metabolic syndrome and classic cardiovascular risk factors. Exp Ther Med 19: 2766-2772, 2020
APA
Hou, F., Zhou, Y., Liu, W., Yang, S., Wang, Z., Ma, X. ... Guan, J. (2020). Characteristics of culprit lesions in young patients with metabolic syndrome and classic cardiovascular risk factors. Experimental and Therapeutic Medicine, 19, 2766-2772. https://doi.org/10.3892/etm.2020.8484
MLA
Hou, F., Zhou, Y., Liu, W., Yang, S., Wang, Z., Ma, X., Du, Y., Li, Y., Guan, J."Characteristics of culprit lesions in young patients with metabolic syndrome and classic cardiovascular risk factors". Experimental and Therapeutic Medicine 19.4 (2020): 2766-2772.
Chicago
Hou, F., Zhou, Y., Liu, W., Yang, S., Wang, Z., Ma, X., Du, Y., Li, Y., Guan, J."Characteristics of culprit lesions in young patients with metabolic syndrome and classic cardiovascular risk factors". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2766-2772. https://doi.org/10.3892/etm.2020.8484