Anti‑obesity effects of a mixed extract containing Platycodon grandiflorum, Apium graveolens and green tea in high‑fat‑diet‑induced obese mice

Cho,Byoung  Ok; Choi,Jiwon; Kang,Hyun  Ju; Che,Denis  Nchang; Shin,Jae  Young; Kim,Ji‑Su; Kim,Sang  Jun; Jang,Seon  Il

doi:10.3892/etm.2020.8493

Anti‑obesity effects of a mixed extract containing Platycodon grandiflorum, Apium graveolens and green tea in high‑fat‑diet‑induced obese mice

Authors:
- Byoung Ok Cho
- Jiwon Choi
- Hyun Ju Kang
- Denis Nchang Che
- Jae Young Shin
- Ji‑Su Kim
- Sang Jun Kim
- Seon Il Jang
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Affiliations: Research Institute, Ato Q&A Co. Ltd., Jeonju, Jeonbuk 54840, Republic of Korea, Department of Radiological Sciences, Jeonju University, Jeonju, Jeonbuk 55069, Republic of Korea, Department of Health Management, Jeonju University, Jeonju, Jeonbuk 55069, P.R. China, Functional Food (Drug) R&D Team, Jeonju AgroBio‑Materials Institute, Jeonju, Jeonbuk 54810, Republic of Korea
Published online on: February 5, 2020 https://doi.org/10.3892/etm.2020.8493
Pages: 2783-2791

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Abstract

The anti‑obesity effect of a combination of extracts made of Platycodon grandiflorum (PGE), Apium graveolens (AGE) and green tea (GTE) extracts was investigated in a high‑fat diet‑induced obese C57BL/6N mouse model. Body weight, epididymal adipose tissue weight, liver weight, adipocytes size and serum lipid profile, insulin, leptin and glucose levels were investigated. Additionally, hepatic steatosis, injury and oxidative burden were evaluated in the present study. The current study demonstrated that the PGE, AGE, and GTE (PAG) mixture were most effective in preventing obesity and its associated complications compared with the single extracts used alone. This was evidenced by the PAG's prevention of weight gain, reduction of adipocyte size, beneficial effects in serum lipid profile, levels of insulin, leptin and glucose, and the prevention of liver injury by reducing fat accumulation in the liver, decreased GOT and GPT enzymes and the upregulation of liver antioxidant enzymes. These results suggested that PAG may provide insights into functional food ingredients for use in the prevention of obesity.

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