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Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

  • Authors:
    • Jia Hu
    • Wei Zhou
    • Zhiming Zhou
    • Jian Han
    • Wanli Dong
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Cardiovascular Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Imaging Center, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Neurology, The First Affiliated Hospital of Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2497-2504
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    Published online on: February 11, 2020
       https://doi.org/10.3892/etm.2020.8514
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Abstract

Post‑stroke depression (PSD) is the most prevalent psychiatric complication of acute ischemic stroke. The neutrophil‑to‑lymphocyte ratio (NLR) and the platelet‑to‑lymphocyte ratio (PLR) are indicators of inflammation and are associated with stroke and depression. Therefore, the purpose of the present study was to examine the relationship between NLR/PLR and PSD. Retrospective analysis was carried out in 376 patients with first‑ever acute ischemic stroke in the First Affiliated Yijishan Hospital of Wannan Medical College between March 2015 and September 2017. Patients were divided into PSD (n=104; 27.7%) and non‑PSD (n=272; 72.3%) groups according to the Diagnostic and Statistical Manual of Mental Disorders‑IV criteria at 6 months after stroke. Clinical data were collected retrospectively. NLR and PLR were acquired retrospectively from the routine blood tests performed at admission. A total of 120 healthy volunteers from the physical examination center in the First Affiliated Yijishan Hospital of Wannan Medical College were recruited as controls. Using logistic regression analysis, NLR (≥4.02) and PLR (≥203.74) were independently associated with PSD. NLR, odds ratio (OR) 3.926, 95% confidence intervals (CI, 2.365‑7.947), P<0.001; PLR, OR 3.853, 95% CI (2.214‑6.632), P=0.002. The ability of the combined index [area under the receiver operating characteristic curve, 0.701; 95% CI (0.622‑0.780); P<0.001] to diagnose PSD was greater than that of either ratio alone. Higher NLRs and PLRs (≥4th quartile) were associated with PSD with a 5.79‑fold (P<0.001) increase compared with lower levels of both. Higher NLRs and PLRs were found to be associated with depression 6 months after stroke, and the combined index was more meaningful than either alone in the early clinical detection of PSD.
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Copy and paste a formatted citation
Spandidos Publications style
Hu J, Zhou W, Zhou Z, Han J and Dong W: Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke. Exp Ther Med 19: 2497-2504, 2020.
APA
Hu, J., Zhou, W., Zhou, Z., Han, J., & Dong, W. (2020). Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke. Experimental and Therapeutic Medicine, 19, 2497-2504. https://doi.org/10.3892/etm.2020.8514
MLA
Hu, J., Zhou, W., Zhou, Z., Han, J., Dong, W."Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke". Experimental and Therapeutic Medicine 19.4 (2020): 2497-2504.
Chicago
Hu, J., Zhou, W., Zhou, Z., Han, J., Dong, W."Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2497-2504. https://doi.org/10.3892/etm.2020.8514
Copy and paste a formatted citation
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Spandidos Publications style
Hu J, Zhou W, Zhou Z, Han J and Dong W: Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke. Exp Ther Med 19: 2497-2504, 2020.
APA
Hu, J., Zhou, W., Zhou, Z., Han, J., & Dong, W. (2020). Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke. Experimental and Therapeutic Medicine, 19, 2497-2504. https://doi.org/10.3892/etm.2020.8514
MLA
Hu, J., Zhou, W., Zhou, Z., Han, J., Dong, W."Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke". Experimental and Therapeutic Medicine 19.4 (2020): 2497-2504.
Chicago
Hu, J., Zhou, W., Zhou, Z., Han, J., Dong, W."Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2497-2504. https://doi.org/10.3892/etm.2020.8514
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