Application of quantitative analysis of contrast‑enhanced ultrasonography in the evaluation of acute radiation‑induced liver damage

Xin,Tian‑You; Feng,Jun; Chen,Shu‑Bo; Chen,Xian; Guo,Ya‑Yun; Sun,Ping; Chen,Ying‑Zhen

doi:10.3892/etm.2020.8541

April-2020 Volume 19 Issue 4

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April-2020 Volume 19 Issue 4

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Article Open Access

Application of quantitative analysis of contrast‑enhanced ultrasonography in the evaluation of acute radiation‑induced liver damage

Authors:
- Tian‑You Xin
- Jun Feng
- Shu‑Bo Chen
- Xian Chen
- Ya‑Yun Guo
- Ping Sun
- Ying‑Zhen Chen
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Affiliations: Department of Ultrasound, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Oncology, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Pathology, The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China

Copyright: © Xin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2957-2962
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Published online on: February 21, 2020

https://doi.org/10.3892/etm.2020.8541
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Abstract

The aim of the present study was to evaluate the microcirculation perfusion in patients with acute radiation‑induced liver damage (RILD) and explore the feasibility of non‑invasive evaluation of RILD using quantitative analysis of contrast‑enhanced ultrasound (CEUS). Patients who successfully underwent three‑dimensional conformal intensity‑modulated radiotherapy for abdominal tumors were selected. CEUS was performed on the liver prior to and 2, 3 and 4 weeks after exposure, and the time‑intensity curve (TIC) was obtained by quantitative analysis of CEUS. The time to peak (TTP), gradient (Grad) and area under the curve (AUC) were analyzed offline. The Grad of the CEUS TIC was decreased and TTP increased with the prolongation of the irradiation duration, with statistically significant differences between the values in the 2‑, 3‑ and 4‑week groups vs. those prior to exposure (P<0.05), as well as among the values of the 2‑, 3‑ and 4‑week groups (P<0.05). Following irradiation, the AUC decreased gradually in the 2‑ and 3‑week groups and increased in the 4‑week group, with statistically significant differences compared with the AUC prior to irradiation (P<0.05). The quantitative analysis parameters of CEUS may be important reference parameters for the early diagnosis of acute RILD.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Application of quantitative analysis of contrast‑enhanced ultrasonography in the evaluation of acute radiation‑induced liver damage

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