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Association between microRNA machinery gene polymorphisms and recurrent implantation failure

  • Authors:
    • Yubin Lee
    • Eun Hee Ahn
    • Chang Soo Ryu
    • Jung Oh Kim
    • Hui Jeong An
    • Sung Hwan Cho
    • Ji Hyang Kim
    • Young Ran Kim
    • Woo Sik Lee
    • Nam Keun Kim
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul 06135, Republic of Korea, Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi 13497, Republic of Korea, Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Gyeonggi 13488, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3113-3123
    |
    Published online on: February 26, 2020
       https://doi.org/10.3892/etm.2020.8556
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Abstract

The present study aimed to investigate the potential association of five miRNA machinery gene polymorphisms (DICER1 rs3742330A>G, DROSHA rs10719T>C, RAN rs14035C>T, XPO5 rs11077A>C and DGCR8 rs417309G>A) with recurrent implantation failure (RIF), a clinical condition in which good‑quality embryos repeatedly fail to implant following two or more in vitro fertilization cycles, and its associated risk factors in Korean women. Therefore, the present study performed genotype analysis and assessed the frequency of these miRNA gene polymorphisms in patients diagnosed with RIF (n=119) and randomly selected controls (n=210) with at least one live birth and no history of pregnancy loss. The DROSHA rs10719T>C and RAN rs14035C>T polymorphisms were identified to be significantly associated with decreased prevalence of RIF. Additionally, the DROSHA rs10719 TC and the RAN rs14035 CT genotypes were present at significantly lower frequencies in the RIF group than in the control group (adjusted odds ratio=0.550; 95% CI, 0.339‑0.893; P=0.016; and adjusted odds ratio=0.590; 95% CI, 0.363‑0.958; P=0.033, respectively). Furthermore, the combined RAN rs14035 CT+TT genotype was observed to be associated with decreased RIF prevalence (adjusted odds ratio=0.616; 95% CI, 0.386‑0.982; P=0.042). Genotype combination analysis for the various miRNA polymorphisms revealed that the DROSHA TC genotype exhibited a highly significant negative association with RIF prevalence when combined with the RAN CT genotype (adjusted odds ratio=0.314; 95% CI, 0.147‑0.673; P=0.003; false discovery rate‑adjusted P=0.023). The present study revealed an association between the DROSHA rs10719 and RAN rs14035 3'UTR polymorphisms and decreased risk of RIF in Korean women, which suggests that these gene polymorphisms could represent potential markers for predicting RIF risk.
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1 

Polanski LT, Baumgarten MN, Quenby S, Brosens J, Campbell BK and Raine-Fenning NJ: What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion. Reprod Biomed Online. 28:409–423. 2014.PubMed/NCBI View Article : Google Scholar

2 

Simon A and Laufer N: Repeated implantation failure: Clinical approach. Fertil Steril. 97:1039–1043. 2012.PubMed/NCBI View Article : Google Scholar

3 

Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong K, Sallam H and Li TC: Recurrent implantation failure: Definition and management. Reprod Biomed Online. 28:14–38. 2014.PubMed/NCBI View Article : Google Scholar

4 

Santamaria X and Taylor H: MicroRNA and gynecological reproductive diseases. Fertil Steril. 101:1545–1551. 2014.PubMed/NCBI View Article : Google Scholar

5 

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS and Johnson JM: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. 2005.PubMed/NCBI View Article : Google Scholar

6 

Olena AF and Patton JG: Genomic organization of microRNAs. J Cell Physiol. 222:540–545. 2010.PubMed/NCBI View Article : Google Scholar

7 

Chong MM, Zhang G, Cheloufi S, Neubert TA, Hannon GJ and Littman DR: Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev. 24:1951–1960. 2010.PubMed/NCBI View Article : Google Scholar

8 

Harden ME and Munger K: Perturbation of DROSHA and DICER expression by human papilloma virus 16 oncoproteins. Virology. 507:192–198. 2017.PubMed/NCBI View Article : Google Scholar

9 

Roberts TC: The microRNA machinery. Adv Exp Med Biol. 887:15–30. 2015.PubMed/NCBI View Article : Google Scholar

10 

Al-Zahrani J, Al-Dosari N, Abudheim N, Alshidi TA, Colak D, Al-Habit O, Al-Odaib A, Sakati N, Meyer B, Ozand PT and Kaya N: Chromosome 12q24.31-q24.33 deletion causes multiple dysmorphic features and developmental delay: First mosaic patient and overview of the phenotype related to 12q24qter defects. Mol Cytogenet. 4(9)2011.PubMed/NCBI View Article : Google Scholar

11 

Bueno MT, Martinez-Rios C, la Puente Gregorio A, Ahyad RA, Villani A, Druker H, van Engelen K, Gallinger B, Aronoff L, Grant R, et al: Pediatric imaging in DICER1 syndrome. Pediatr Radiol. 47:1292–1301. 2017.PubMed/NCBI View Article : Google Scholar

12 

Patrao AS, Dias F, Teixeira AL, Mauricio J and Medeiros R: XPO5 genetic polymorphisms in cancer risk and prognosis. Pharmacogenomics. 19:799–808. 2018.PubMed/NCBI View Article : Google Scholar

13 

Revel A, Achache H, Stevens J, Smith Y and Reich R: MicroRNAs are associated with human embryo implantation defects. Hum Reprod. 26:2830–2840. 2011.PubMed/NCBI View Article : Google Scholar

14 

Hu Y, Liu CM, Qi L, He TZ, Shi-Guo L, Hao CJ, Cui Y, Zhang N, Xia HF and Ma X: Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population. RNA Biol. 8:861–872. 2011.PubMed/NCBI View Article : Google Scholar

15 

Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J and Schoolcraft WB: Single blastocyst transfer: A prospective randomized trial. Fertil Steril. 81:551–555. 2004.PubMed/NCBI View Article : Google Scholar

16 

Choi DH, Kim EK, Kim KH, Lee KA, Kang DW, Kim HY, Bridges P and Ko C: Expression pattern of endothelin system components and localization of smooth muscle cells in the human pre-ovulatory follicle. Hum Reprod. 26:1171–1180. 2011.PubMed/NCBI View Article : Google Scholar

17 

Rosen HR, Doherty DG, Madrigal-Estebas L, O'Farrelly C and Golden-Mason L: Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 14:31–40. 2008.PubMed/NCBI View Article : Google Scholar

18 

Ryu CS, Sakong JH, Ahn EH, Kim JO, Ko D, Kim JH, Lee WS and Kim NK: Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss. Genes Genomics. 41:61–70. 2019.PubMed/NCBI View Article : Google Scholar

19 

Benjamini Y, Drai D, Elmer G, Kafkafi N and Golani I: Controlling the false discovery rate in behavior genetics research. Behav Brain Res. 125:279–284. 2001.PubMed/NCBI View Article : Google Scholar

20 

Hahn LW, Ritchie MD and Moore JH: Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics. 19:376–382. 2003.PubMed/NCBI View Article : Google Scholar

21 

Jeon YJ, Choi YS, Rah H, Kim SY, Choi DH, Cha SH, Shin JE, Shim SH, Lee WS and Kim NK: Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women. Gene. 494:168–173. 2012.PubMed/NCBI View Article : Google Scholar

22 

Kim JO, Bae J, Kim J, Oh SH, An HJ, Han IB, Oh D, Kim OJ and Kim NK: Association of microRNA biogenesis genes polymorphisms with ischemic stroke susceptibility and post-stroke mortality. J Stroke. 20:110–121. 2018.PubMed/NCBI View Article : Google Scholar

23 

Saeki M, Watanabe M, Inoue N, Tokiyoshi E, Takuse Y, Arakawa Y, Hidaka Y and Iwatani Y: DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases. Autoimmunity. 49:514–522. 2016.PubMed/NCBI View Article : Google Scholar

24 

Zhang Y, Cao AL and Dong C: Rs10719 Polymorphism located within DROSHA 3'-untranslated region is responsible for development of primary hypertension by disrupting binding with microRNA-27b. Med Sci Monit. 23:911–918. 2017.PubMed/NCBI View Article : Google Scholar

25 

Rezaei M, Eskandari F, Mohammadpour-Gharehbagh A, Teimoori B, Yaghmaei M, Mokhtari M and Salimi S: The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility. Clin Exp Hypertens. 40:440–445. 2018.PubMed/NCBI View Article : Google Scholar

26 

Huang JT, Wang J, Srivastava V, Sen S and Liu SM: MicroRNA machinery genes as novel biomarkers for cancer. Front Oncol. 4(113)2014.PubMed/NCBI View Article : Google Scholar

27 

Lin S and Gregory RI: MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 15:321–333. 2015.PubMed/NCBI View Article : Google Scholar

28 

Torres A, Torres K, Paszkowski T, Jodłowska-Jędrych B, Radomański T, Książek A and Maciejewski R: Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer. Tumour Biol. 32:769–776. 2011.PubMed/NCBI View Article : Google Scholar

29 

Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Nick AM, et al: Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 359:2641–2650. 2008.PubMed/NCBI View Article : Google Scholar

30 

Cho SH, Ko JJ, Kim JO, Jeon YJ, Yoo JK, Oh J, Oh D, Kim JW and Kim NK: 3'-UTR polymorphisms in the MiRNA machinery genes DROSHA, DICER1, RAN, and XPO5 are associated with colorectal cancer risk in a Korean population. PLoS One. 10(e0131125)2015.PubMed/NCBI View Article : Google Scholar

31 

Muralidhar B, Goldstein LD, Ng G, Winder DM, Palmer RD, Gooding EL, Barbosa-Morais NL, Mukherjee G, Thorne NP, Roberts I, et al: Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels. J Pathol. 212:368–377. 2007.PubMed/NCBI View Article : Google Scholar

32 

Zhang C, Long X, Ding Y, Chen X, He J, Liu S, Geng Y, Wang Y and Liu X: Expression of DROSHA in the uterus of mice in early pregnancy and its potential significance during embryo implantation. Reprod Sci. 23:154–162. 2016.PubMed/NCBI View Article : Google Scholar

33 

Jung YW, Jeon YJ, Rah H, Kim JH, Shin JE, Choi DH, Cha SH and Kim NK: Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk. PLoS One. 9(e95803)2014.PubMed/NCBI View Article : Google Scholar

34 

Fu M, Xu WM, Qin TZ and Xu KH: The association between the polymorphisms of miRNA biogenesis related genes (DICER,DROSHA and RAN) and unexplained recurrent spontaneous abortion in Chinese women. Sichuan Da Xue Xue Bao Yi Xue Ban. 48:880–885. 2017.(In Chinese). PubMed/NCBI

35 

Khuperkar D, Helen M, Magre I and Joseph J: Inter-cellular transport of ran GTPase. PLoS One. 10(e0125506)2015.PubMed/NCBI View Article : Google Scholar

36 

Aoki K and Niki H: Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus. Biol Open. 6:1614–1628. 2017.PubMed/NCBI View Article : Google Scholar

37 

Kurisetty VV, Johnston PG, Johnston N, Erwin P, Crowe P, Fernig DG, Campbell FC, Anderson IP, Rudland PS and El-Tanani MK: RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin. Oncogene. 27:7139–7149. 2008.PubMed/NCBI View Article : Google Scholar

38 

Fan H, Lu Y, Qin H, Zhou Y, Gu Y, Zhou J, Wang X and Fan D: High Ran level is correlated with poor prognosis in patients with colorectal cancer. Int J Clin Oncol. 18:856–863. 2013.PubMed/NCBI View Article : Google Scholar

39 

Yuen HF, Chan KK, Platt-Higgins A, Dakir el-H, Matchett KB, Haggag YA, Jithesh PV, Habib T, Faheem A, Dean FA, et al: Ran GTPase promotes cancer progression via Met receptor-rmediated downstream signaling. Oncotarget. 7:75854–75864. 2016.PubMed/NCBI View Article : Google Scholar

40 

Practice Committee of American Society for Reproductive Medicine: Definitions of infertility and recurrent pregnancy loss: A committee opinion. Fertil Steril 99: 63, 2013.

41 

Rashid NA, Lalitkumar S, Lalitkumar PG and Gemzell-Danielsson K: Endometrial receptivity and human embryo implantation. Am J Reprod Immunol. 66 (Suppl 1):S23–S30. 2011.PubMed/NCBI View Article : Google Scholar

42 

Sheppard HM, Verdon D, Brooks AE, Feisst V, Ho YY, Lorenz N, Fan V, Birch NP, Didsbury A and Dunbar PR: MicroRNA regulation in human CD8+ T cell subsets-cytokine exposure alone drives miR-146a expression. J Transl Med. 12(292)2014.PubMed/NCBI View Article : Google Scholar

43 

Baumann FM, Yuzefpolskiy Y, Sarkar S and Kalia V: Dicer regulates the balance of short-lived effector and long-lived memory CD8 T cell lineages. PLoS One. 11(e0162674)2016.PubMed/NCBI View Article : Google Scholar

44 

Zhang N and Bevan MJ: Dicer controls CD8+ T-cell activation, migration, and survival. Proc Natl Acad Sci USA. 107:21629–21634. 2010.PubMed/NCBI View Article : Google Scholar

45 

Chernyshov VP, Sudoma IO, Dons'koi BV, Kostyuchyk AA and Masliy YV: Elevated NK cell cytotoxicity, CD158a expression in NK cells and activated T lymphocytes in peripheral blood of women with IVF failures. Am J Reprod Immunol. 64:58–67. 2010.PubMed/NCBI View Article : Google Scholar

46 

Yang KM, Ntrivalas E, Cho HJ, Kim NY, Beaman K, Gilman-Sachs A and Kwak-Kim J: Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation. Am J Reprod Immunol. 63:370–378. 2010.PubMed/NCBI View Article : Google Scholar

47 

Yin B, Zeng Y, Wu T, Yu S, Xu J, Liu S, Diao L, Zhao Z, Liang D and Li Y: Functional properties of peripheral CD8+ T cells in patients with repeated implantation failure. Am J Reprod Immunol. 78:2017.PubMed/NCBI View Article : Google Scholar

48 

Alecsandru D and Garcia-Velasco JA: Why natural killer cells are not enough: A further understanding of killer immunoglobulin-like receptor and human leukocyte antigen. Fertil Steril. 107:1273–1278. 2017.PubMed/NCBI View Article : Google Scholar

49 

Pan Q and Chegini N: MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med. 26:479–493. 2008.PubMed/NCBI View Article : Google Scholar

50 

Galliano D and Pellicer A: MicroRNA and implantation. Fertil Steril. 101:1531–1544. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lee Y, Ahn EH, Ryu CS, Kim JO, An HJ, Cho SH, Kim JH, Kim YR, Lee WS, Kim NK, Kim NK, et al: Association between microRNA machinery gene polymorphisms and recurrent implantation failure. Exp Ther Med 19: 3113-3123, 2020.
APA
Lee, Y., Ahn, E.H., Ryu, C.S., Kim, J.O., An, H.J., Cho, S.H. ... Kim, N.K. (2020). Association between microRNA machinery gene polymorphisms and recurrent implantation failure. Experimental and Therapeutic Medicine, 19, 3113-3123. https://doi.org/10.3892/etm.2020.8556
MLA
Lee, Y., Ahn, E. H., Ryu, C. S., Kim, J. O., An, H. J., Cho, S. H., Kim, J. H., Kim, Y. R., Lee, W. S., Kim, N. K."Association between microRNA machinery gene polymorphisms and recurrent implantation failure". Experimental and Therapeutic Medicine 19.4 (2020): 3113-3123.
Chicago
Lee, Y., Ahn, E. H., Ryu, C. S., Kim, J. O., An, H. J., Cho, S. H., Kim, J. H., Kim, Y. R., Lee, W. S., Kim, N. K."Association between microRNA machinery gene polymorphisms and recurrent implantation failure". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3113-3123. https://doi.org/10.3892/etm.2020.8556
Copy and paste a formatted citation
x
Spandidos Publications style
Lee Y, Ahn EH, Ryu CS, Kim JO, An HJ, Cho SH, Kim JH, Kim YR, Lee WS, Kim NK, Kim NK, et al: Association between microRNA machinery gene polymorphisms and recurrent implantation failure. Exp Ther Med 19: 3113-3123, 2020.
APA
Lee, Y., Ahn, E.H., Ryu, C.S., Kim, J.O., An, H.J., Cho, S.H. ... Kim, N.K. (2020). Association between microRNA machinery gene polymorphisms and recurrent implantation failure. Experimental and Therapeutic Medicine, 19, 3113-3123. https://doi.org/10.3892/etm.2020.8556
MLA
Lee, Y., Ahn, E. H., Ryu, C. S., Kim, J. O., An, H. J., Cho, S. H., Kim, J. H., Kim, Y. R., Lee, W. S., Kim, N. K."Association between microRNA machinery gene polymorphisms and recurrent implantation failure". Experimental and Therapeutic Medicine 19.4 (2020): 3113-3123.
Chicago
Lee, Y., Ahn, E. H., Ryu, C. S., Kim, J. O., An, H. J., Cho, S. H., Kim, J. H., Kim, Y. R., Lee, W. S., Kim, N. K."Association between microRNA machinery gene polymorphisms and recurrent implantation failure". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3113-3123. https://doi.org/10.3892/etm.2020.8556
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