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Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials

  • Authors:
    • Qing‑Bo Wei
    • Ning Ding
    • Jiao‑Jiao Wang
    • Wei Wang
    • Wei‑Ping Gao
  • View Affiliations / Copyright

    Affiliations: Ophthalmology Department of Traditional Chinese Medicine, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, School of Healthcare Sciences, Cardiff University, Cardiff, CF10 3AT, UK
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2851-2860
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    Published online on: February 26, 2020
       https://doi.org/10.3892/etm.2020.8561
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Abstract

The effectiveness of acupuncture in the treatment of dry eye has been confirmed, but the association between acupoint selection and therapeutic effect has remained to be elucidated. In the present study, a systematic review and meta‑analysis were performed to evaluate the effect of periocular acupoints and periocular acupoints plus body acupoints compared with AT for the treatment of dry eye disease (DED). The PubMed, Cochrane Library, Embase, Ovid, China National Knowledge Infrastructure and Chonqing VIP Information, Co., Ltd. databases were searched with entries until 10 July 2018 considered. Only randomized controlled trials (RCTs) were included. Meta‑analyses were performed to compare the effects of acupuncture with those of conventional treatment (including AT or other non‑acupuncture therapies). The primary outcomes, including tear break‑up time (BUT), Schirmer's I test (SIT) result and Symptom scores were analyzed. Subgroup analysis was performed for periocular acupoints only and periocular acupoints plus body acupoints. A total of 12 studies comprising 900 participants were included. In the primary meta‑analysis, a significant improvement in the BUT [n=1,209, weighted mean difference (WMD)=1.01, 95% CI: 0.56‑1.84, P<0.00001], SIT result (n=1,107, WMD=1.98, 95% CI: 0.44‑3.34, P<0.00001) and Symptom scores (n=402, WMD=‑1.02, 95% CI: ‑1.33 to ‑0.72, P<0.00001) was obtained to evaluate the clinical efficacy of acupuncture and AT. Furthermore, periocular acupoints plus body acupoints were more effective in the treatment of DED. However, the total sample size of subjects with only periocular acupoints in the treatment of DED was too small to get any firm conclusions. Further large RCTs are warranted.
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Copy and paste a formatted citation
Spandidos Publications style
Wei QB, Ding N, Wang JJ, Wang W and Gao WP: Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials. Exp Ther Med 19: 2851-2860, 2020.
APA
Wei, Q., Ding, N., Wang, J., Wang, W., & Gao, W. (2020). Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 19, 2851-2860. https://doi.org/10.3892/etm.2020.8561
MLA
Wei, Q., Ding, N., Wang, J., Wang, W., Gao, W."Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 19.4 (2020): 2851-2860.
Chicago
Wei, Q., Ding, N., Wang, J., Wang, W., Gao, W."Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2851-2860. https://doi.org/10.3892/etm.2020.8561
Copy and paste a formatted citation
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Spandidos Publications style
Wei QB, Ding N, Wang JJ, Wang W and Gao WP: Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials. Exp Ther Med 19: 2851-2860, 2020.
APA
Wei, Q., Ding, N., Wang, J., Wang, W., & Gao, W. (2020). Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 19, 2851-2860. https://doi.org/10.3892/etm.2020.8561
MLA
Wei, Q., Ding, N., Wang, J., Wang, W., Gao, W."Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 19.4 (2020): 2851-2860.
Chicago
Wei, Q., Ding, N., Wang, J., Wang, W., Gao, W."Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2851-2860. https://doi.org/10.3892/etm.2020.8561
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