Open Access

Dynamics of digital ulcers in systemic sclerosis

  • Authors:
    • Carmen Bobeică
    • Alin Laurențiu Tatu
    • Mihaela Crăescu
    • Laura Solovăstru
  • View Affiliations

  • Published online on: February 27, 2020     https://doi.org/10.3892/etm.2020.8572
  • Pages: 61-67
  • Copyright: © Bobeică et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. A group of 22 patients diagnosed with SSc, hospitalized in a university clinic in Bucharest was included in an observational study. The evolution of digital ulcers was evaluated as an indicator of vasculopathy and their status and dynamics were correlated with clinical elements reflecting the fibrotic aspect of the disease. The present study shows that the Raynaud phenomenon is almost always present during the course of the disease, but its presence is not always associated with digital ulcers. The existing data in the literature show that fibrosis is subsequent to vasculopathy, but this study did not reveal causality between these two aspects of pathogenesis. The presence of microstomia and digital contracture was identified in the presence of digital ulcers, but also in their absence. The etiopathogenic mechanisms with multiple unknown involved factors open the opportunity to investigate many aspects of SSc for optimal aiming of therapeutic interventions.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bobeică C, Tatu AL, Crăescu M and Solovăstru L: Dynamics of digital ulcers in systemic sclerosis. Exp Ther Med 20: 61-67, 2020
APA
Bobeică, C., Tatu, A.L., Crăescu, M., & Solovăstru, L. (2020). Dynamics of digital ulcers in systemic sclerosis. Experimental and Therapeutic Medicine, 20, 61-67. https://doi.org/10.3892/etm.2020.8572
MLA
Bobeică, C., Tatu, A. L., Crăescu, M., Solovăstru, L."Dynamics of digital ulcers in systemic sclerosis". Experimental and Therapeutic Medicine 20.1 (2020): 61-67.
Chicago
Bobeică, C., Tatu, A. L., Crăescu, M., Solovăstru, L."Dynamics of digital ulcers in systemic sclerosis". Experimental and Therapeutic Medicine 20, no. 1 (2020): 61-67. https://doi.org/10.3892/etm.2020.8572