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Article

Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children

  • Authors:
    • Lun Qin Liu
    • Zhi Hua Wang
    • Hai Yun Yao
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    Affiliations: Department of Inspection, Infectious Diseases Hospital of Jinan, Jinan, Shandong 250021, P.R. China, Department of Pediatrics, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, P.R. China, Department of Inspection, Jinan Blood Center, Jinan, Shandong 250001, P.R. China
  • Pages: 3432-3438
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    Published online on: March 12, 2020
       https://doi.org/10.3892/etm.2020.8596
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Abstract

The objective of the present study was to explore the role of hepatocyte growth factor (HGF) in directing treatment of Mycoplasma pneumoniae pneumonia (MP). Serum levels of HGF were assessed using ELISA in 65 pediatric patients with MP, 42 with bacterial pneumonia and 30 healthy controls. Serum levels of C‑reactive protein (CRP), the standard guide for MP treatment, were also examined in severe and non‑severe MP. The sensitivity and specificity of HGF and CRP in assessing the outcome of azithromycin treatment of MP were compared using receiver operating characteristic curves. HGF levels were elevated in MP and bacterial pneumonia patients compared with healthy controls. HGF levels were also significantly higher in severe MP than in non‑severe MP. HGF showed higher sensitivity and specificity than CRP in assessing outcomes of azithromycin treatment of MP. The results of the present study indicated that HGF may be used to detect severe MP and to direct its management. Furthermore, HGF may be better predictive marker to assess the effectiveness of azithromycin treatment of MP than CRP.
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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Wang Z and Yao H: Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children. Exp Ther Med 19: 3432-3438, 2020.
APA
Liu, L., Wang, Z., & Yao, H. (2020). Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children. Experimental and Therapeutic Medicine, 19, 3432-3438. https://doi.org/10.3892/etm.2020.8596
MLA
Liu, L., Wang, Z., Yao, H."Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children". Experimental and Therapeutic Medicine 19.5 (2020): 3432-3438.
Chicago
Liu, L., Wang, Z., Yao, H."Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3432-3438. https://doi.org/10.3892/etm.2020.8596
Copy and paste a formatted citation
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Spandidos Publications style
Liu L, Wang Z and Yao H: Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children. Exp Ther Med 19: 3432-3438, 2020.
APA
Liu, L., Wang, Z., & Yao, H. (2020). Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children. Experimental and Therapeutic Medicine, 19, 3432-3438. https://doi.org/10.3892/etm.2020.8596
MLA
Liu, L., Wang, Z., Yao, H."Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children". Experimental and Therapeutic Medicine 19.5 (2020): 3432-3438.
Chicago
Liu, L., Wang, Z., Yao, H."Hepatocyte growth factor can guide treatment of Mycoplasma pneumoniae pneumonia in children". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3432-3438. https://doi.org/10.3892/etm.2020.8596
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