Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis

  • Authors:
    • De‑Feng Li
    • Xin Chang
    • Xue Fang
    • Jian‑Yao Wang
    • Zhi‑Chao Yu
    • Cheng Wei
    • Feng Xiong
    • Zheng‑Lei Xu
    • Ding‑Guo Zhang
    • Ting‑Ting Liu
    • Ming‑Han Luo
    • Li‑Sheng Wang
    • Jun Yao
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Clinical Medicine College (Shenzhen People's Hospital) of Jinan University, Shenzhen, Guangdong 518020, P.R. China, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong 518020, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3211-3218
    |
    Published online on: March 12, 2020
       https://doi.org/10.3892/etm.2020.8597
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Current guidelines recommend temporary cessation of clopidogrel for 7‑10 days for patients on clopidogrel undergoing colonoscopy with polypectomy. However, recent prospective randomized controlled trials have advocated for uninterrupted clopidogrel, due to similar post‑polypectomy bleeding (PPB) rates with and without continued clopidogrel therapy. Thus, a meta‑analysis was conducted to assess the risk of PPB rate in patients on continued clopidogrel therapy. Systemically identified publications were used to compare the rate of PPB in patients on continued clopidogrel therapy with those who had interrupted clopidogrel therapy. The primary outcome was the incidence of PPB. The secondary outcomes were immediate PPB, delayed PPB and serious cardio‑thrombotic events. This study has been registered in PROSPERO (no. CRD42018118325). A total of five studies were identified, which included 655 patients in the continued clopidogrel group and 6620 patients in the control group. There was an increased risk of PPB with continued clopidogrel [P=0.0003; risk ratio (RR), 1.96; 95% confidence interval (CI), 1.36‑2.83). The rate of immediate PPB was slightly higher in the continued clopidogrel group (5.77% vs. 1.77%, respectively), but was not statistically significant (P=0.06; RR, 1.57; 95%CI, 0.98‑2.51). The rate of delayed PPB was increased in the continued clopidogrel group (P=0.0008; RR, 3.10; 95%CI, 1.60‑5.98). However, no significant difference in serious cardio‑thrombotic events was observed within 30 days (P=0.74; RR, 0.78; 95%CI, 0.18‑3.40). Although continued clopidogrel therapy decreased the incidence of serious cardio‑thrombotic events, the risk of delayed PPB was increased. Therefore, endoscopists should make all preparations to prevent bleeding in the perioperative period for patients at high thrombotic risk and on continued clopidogrel therapy, if polypectomy cannot be reasonably postponed.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Kim AS and Johnston SC: Global variation in the relative burden of stroke and ischemic heart disease. Circulation. 124:314–323. 2011.PubMed/NCBI View Article : Google Scholar

2 

Writing Group Members. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, et al: Executive summary: Heart disease and stroke statistics-2016 update: A report from the American heart association. Circulation. 133:447–454. 2016.PubMed/NCBI View Article : Google Scholar

3 

Rosen L, Bub DS, Reed JF III and Nastasee SA: Hemorrhage following colonoscopic polypectomy. Dis Colon Rectum. 36:1126–1131. 1993.PubMed/NCBI View Article : Google Scholar

4 

Reaume KT, Regal RE and Dorsch MP: Indications for dual antiplatelet therapy with aspirin and clopidogrel: Evidence-based recommendations for use. Ann Pharmacother. 42:550–557. 2008.PubMed/NCBI View Article : Google Scholar

5 

Spertus JA, Kettelkamp R, Vance C, Decker C, Jones PG, Rumsfeld JS, Messenger JC, Khanal S, Peterson ED, Bach RG, et al: Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: Results from the PREMIER registry. Circulation. 113:2803–2809. 2006.PubMed/NCBI View Article : Google Scholar

6 

Singh M, Mehta N, Murthy UK, Kaul V, Arif A and Newman N: Postpolypectomy bleeding in patients undergoing colonoscopy on uninterrupted clopidogrel therapy. Gastrointest Endosc. 71:998–1005. 2010.PubMed/NCBI View Article : Google Scholar

7 

Carter D, Beer-Gabel M, Eliakim R, Novis B, Avidan B and Bardan E: Management of antithrombotic agents for colonoscopic polypectomies in Israeli gastroenterologists relative to published guidelines. Clin Res Hepatol Gastroenterol. 37:514–518. 2013.PubMed/NCBI View Article : Google Scholar

8 

Feagins LA, Uddin FS, Davila RE, Harford WV and Spechler SJ: The rate of post-polypectomy bleeding for patients on uninterrupted clopidogrel therapy during elective colonoscopy is acceptably low. Dig Dis Sci. 56:2631–2638. 2011.PubMed/NCBI View Article : Google Scholar

9 

Feagins LA, Iqbal R, Harford WV, Halai A, Cryer BL, Dunbar KB, Davila RE and Spechler SJ: Low rate of postpolypectomy bleeding among patients who continue thienopyridine therapy during colonoscopy. Clin Gastroenterol Hepatol. 11:1325–1332. 2013.PubMed/NCBI View Article : Google Scholar

10 

Gandhi S, Narula N, Mosleh W, Marshall JK and Farkouh M: Meta-analysis: Colonoscopic post-polypectomy bleeding in patients on continued clopidogrel therapy. Aliment Pharmacol Ther. 37:947–952. 2013.PubMed/NCBI View Article : Google Scholar

11 

Shalman D and Gerson LB: Systematic review with meta-analysis: The risk of gastrointestinal haemorrhage post-polypectomy in patients receiving anti-platelet, anti-coagulant and/or thienopyridine medications. Aliment Pharmacol Ther. 42:949–956. 2015.PubMed/NCBI View Article : Google Scholar

12 

Kato M, Uedo N, Hokimoto S, Ieko M, Higuchi K, Murakami K and Fujimoto K: Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment: 2017 appendix on anticoagulants including direct oral anticoagulants. Dig Endosc. 30:433–440. 2018.PubMed/NCBI View Article : Google Scholar

13 

Chan FKL, Goh KL, Reddy N, Fujimoto K, Ho KY, Hokimoto S, Jeong YH, Kitazono T, Lee HS, Mahachai V, et al: Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: Joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines. Gut. 67:405–417. 2018.PubMed/NCBI View Article : Google Scholar

14 

Mehran R, Baber U, Steg PG, Ariti C, Weisz G, Witzenbichler B, Henry TD, Kini AS, Stuckey T, Cohen DJ, et al: Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet. 382:1714–1722. 2013.PubMed/NCBI View Article : Google Scholar

15 

Eisenberg MJ, Richard PR, Libersan D and Filion KB: Safety of short-term discontinuation of antiplatelet therapy in patients with drug-eluting stents. Circulation. 119:1634–1642. 2009.PubMed/NCBI View Article : Google Scholar

16 

Chan FKL, Kyaw MH, Hsiang JC, Suen BY, Kee KM, Tse YK, Ching JYL, Cheong PK, Ng D, Lam K, et al: Risk of postpolypectomy bleeding with uninterrupted clopidogrel therapy in an industry-independent, double-blind, randomized trial. Gastroenterology. 156:918–925. 2019.PubMed/NCBI View Article : Google Scholar

17 

Plumé Gimeno G, Bustamante-Balén M, Satorres Paniagua C, Díaz Jaime FC and Cejalvo Andújar MJ: Endoscopic resection of colorectal polyps in patients on antiplatelet therapy: An evidence-based guidance for clinicians. Rev Esp Enferm Dig. 109:49–59. 2017.PubMed/NCBI View Article : Google Scholar

18 

Abdel Samie A, Theilmann L and Labenz J: ALGK : Endoscopic procedures in patients under clopidogrel or dual antiplatelet therapy: A survey among German gastroenterologists and current guidelines. Z Gastroenterol. 52:425–428. 2014.PubMed/NCBI View Article : Google Scholar

19 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Ann Intern Med. 151:W65–W94. 2009.PubMed/NCBI View Article : Google Scholar

20 

Nelson DB, McQuaid KR, Bond JH, Lieberman DA, Weiss DG and Johnston TK: Procedural success and complications of large-scale screening colonoscopy. Gastrointest Endosc. 55:307–314. 2002.PubMed/NCBI View Article : Google Scholar

21 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA and Thacker SB: Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000.PubMed/NCBI View Article : Google Scholar

22 

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ and McQuay HJ: Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 17:1–12. 1996.PubMed/NCBI View Article : Google Scholar

23 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003.PubMed/NCBI View Article : Google Scholar

24 

Grossman EB, Maranino AN, Zamora DC, et al: Antiplatelet Medications Increase the Risk of Post-Polypectomy Bleeding. GastrointestEndosc. 71(AB138)2010.

25 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018.PubMed/NCBI View Article : Google Scholar

26 

Zhao D, Liu J, Wang M, Zhang X and Zhou M: Epidemiology of cardiovascular disease in China: Current features and implications. Nat Rev Cardiol. 16:203–212. 2019.PubMed/NCBI View Article : Google Scholar

27 

Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G, Airoldi F, Chieffo A, Montorfano M, Carlino M, et al: Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA. 293:2126–2130. 2005.PubMed/NCBI View Article : Google Scholar

28 

Kim HS, Kim TI, Kim WH, Kim YH, Kim HJ, Yang SK, Myung SJ, Byeon JS, Lee MS, Chung IK, et al: Risk factors for immediate postpolypectomy bleeding of the colon: A multicenter study. Am J Gastroenterol. 101:1333–1341. 2006.PubMed/NCBI View Article : Google Scholar

29 

Sawhney MS, Salfiti N, Nelson DB, Lederle FA and Bond JH: Risk factors for severe delayed postpolypectomy bleeding. Endoscopy. 40:115–119. 2008.PubMed/NCBI View Article : Google Scholar

30 

Watabe H, Yamaji Y, Okamoto M, Kondo S, Ohta M, Ikenoue T, Kato J, Togo G, Matsumura M, Yoshida H, et al: Risk assessment for delayed hemorrhagic complication of colonic polypectomy: Polyp-related factors and patient-related factors. Gastrointest Endosc. 64:73–78. 2006.PubMed/NCBI View Article : Google Scholar

31 

Rutter MD, Nickerson C, Rees CJ, Patnick J and Blanks RG: Risk factors for adverse events related to polypectomy in the English Bowel Cancer Screening Programme. Endoscopy. 46:90–97. 2014.PubMed/NCBI View Article : Google Scholar

32 

Choung BS, Kim SH, Ahn DS, Kwon DH, Koh KH, Sohn JY, Park WS, Kim IH, Lee SO, Lee ST and Kim SW: Incidence and risk factors of delayed postpolypectomy bleeding: A retrospective cohort study. J Clin Gastroenterol. 48:784–789. 2014.PubMed/NCBI View Article : Google Scholar

33 

Heldwein W, Dollhopf M, Rösch T, Meining A, Schmidtsdorff G, Hasford J, Hermanek P, Burlefinger R, Birkner B, Schmitt W, et al: The Munich Polypectomy Study (MUPS): Prospective analysis of complications and risk factors in 4000 colonic snare polypectomies. Endoscopy. 37:1116–1122. 2005.PubMed/NCBI View Article : Google Scholar

34 

Rabeneck L, Paszat LF, Hilsden RJ, Saskin R, Leddin D, Grunfeld E, Wai E, Goldwasser M, Sutradhar R and Stukel TA: Bleeding and perforation after outpatient colonoscopy and their risk factors in usual clinical practice. Gastroenterology. 135:1899–1906.e1891. 2008.PubMed/NCBI View Article : Google Scholar

35 

Parikh ND, Zanocco K, Keswani RN and Gawron AJ: A cost-efficacy decision analysis of prophylactic clip placement after endoscopic removal of large polyps. Clin Gastroenterol Hepatol. 11:1319–1324. 2013.PubMed/NCBI View Article : Google Scholar

36 

Matsumoto M, Kato M, Oba K, Abiko S, Tsuda M, Miyamoto S, Mizushima T, Ono M, Omori S, Takahashi M, et al: Multicenter randomized controlled study to assess the effect of prophylactic clipping on post-polypectomy delayed bleeding. Dig Endosc. 28:570–576. 2016.PubMed/NCBI View Article : Google Scholar

37 

Boumitri C, Mir FA, Ashraf I, Matteson-Kome ML, Nguyen DL, Puli SR and Bechtold ML: Prophylactic clipping and post-polypectomy bleeding: A meta-analysis and systematic review. Ann Gastroenterol. 29:502–508. 2016.PubMed/NCBI View Article : Google Scholar

38 

Dokoshi T, Fujiya M, Tanaka K, Sakatani A, Inaba Y, Ueno N, Kashima S, Goto T, Sasajima J, Tominaga M, et al: A randomized study on the effectiveness of prophylactic clipping during endoscopic resection of colon polyps for the prevention of delayed bleeding. Biomed Res Int. 2015(490272)2015.PubMed/NCBI View Article : Google Scholar

39 

Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV and Kaltenbach T: Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications. Gastrointest Endosc. 87:1106–1113. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li DF, Chang X, Fang X, Wang JY, Yu ZC, Wei C, Xiong F, Xu ZL, Zhang DG, Liu TT, Liu TT, et al: Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis. Exp Ther Med 19: 3211-3218, 2020.
APA
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C. ... Yao, J. (2020). Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 19, 3211-3218. https://doi.org/10.3892/etm.2020.8597
MLA
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C., Xiong, F., Xu, Z., Zhang, D., Liu, T., Luo, M., Wang, L., Yao, J."Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 19.5 (2020): 3211-3218.
Chicago
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C., Xiong, F., Xu, Z., Zhang, D., Liu, T., Luo, M., Wang, L., Yao, J."Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3211-3218. https://doi.org/10.3892/etm.2020.8597
Copy and paste a formatted citation
x
Spandidos Publications style
Li DF, Chang X, Fang X, Wang JY, Yu ZC, Wei C, Xiong F, Xu ZL, Zhang DG, Liu TT, Liu TT, et al: Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis. Exp Ther Med 19: 3211-3218, 2020.
APA
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C. ... Yao, J. (2020). Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 19, 3211-3218. https://doi.org/10.3892/etm.2020.8597
MLA
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C., Xiong, F., Xu, Z., Zhang, D., Liu, T., Luo, M., Wang, L., Yao, J."Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 19.5 (2020): 3211-3218.
Chicago
Li, D., Chang, X., Fang, X., Wang, J., Yu, Z., Wei, C., Xiong, F., Xu, Z., Zhang, D., Liu, T., Luo, M., Wang, L., Yao, J."Colonoscopic post‑polypectomy bleeding in patients on uninterruptedclopidogrel therapy: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3211-3218. https://doi.org/10.3892/etm.2020.8597
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team