Open Access

Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells

  • Authors:
    • Leqi Dong
    • Kelei Zhu
    • Mingliang Chen
    • Dingyao Li
    • Cunbin Jiang
    • Lei Chen
  • View Affiliations

  • Published online on: March 17, 2020     https://doi.org/10.3892/etm.2020.8604
  • Pages: 3377-3383
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long non-coding RNA gastric cancer associated transcript 3 (GACAT3), is a newly identified non‑coding RNA, which has been found to be involved in the tumorigenesis of gastric cancer. However, the biological function of GACAT3 in liver cancer remains unclear. The present study aimed to determine the expression level and function of GACAT3 in liver cancer. The authors cultured liver cancer cells in vitro and GACAT3 was silenced in the cells. Cell proliferation, apoptosis and migration were determined by MTT assay, flow cytometric analysis and transwell assay, respectively. It was demonstrated that GACAT3 was upregulated in liver cancer tissues. The inhibition of GACAT3 decreased the ability of hepatoma cells to proliferate and migrate, and increased apoptosis of the cells. These findings provide the first evidence, to the best of our knowledge, of the exact role of GACAT3 in liver cancer, suggesting GACAT3 as a potential target for liver cancer therapy in the future.

Related Articles

Journal Cover

May 2020
Volume 19 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., & Chen, L. (2020). Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells. Experimental and Therapeutic Medicine, 19, 3377-3383. https://doi.org/10.3892/etm.2020.8604
MLA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19.5 (2020): 3377-3383.
Chicago
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3377-3383. https://doi.org/10.3892/etm.2020.8604