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Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells

  • Authors:
    • Leqi Dong
    • Kelei Zhu
    • Mingliang Chen
    • Dingyao Li
    • Cunbin Jiang
    • Lei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Yinzhou People's Hospital Affiliated to Ningbo University School of Medicine, Ningbo, Zhejiang 315040, P.R. China, Department of Hepatobiliary Surgery, Yinzhou People's Hospital Affiliated to Ningbo University School of Medicine, Ningbo, Zhejiang 315040, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3377-3383
    |
    Published online on: March 17, 2020
       https://doi.org/10.3892/etm.2020.8604
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Abstract

Long non-coding RNA gastric cancer associated transcript 3 (GACAT3), is a newly identified non‑coding RNA, which has been found to be involved in the tumorigenesis of gastric cancer. However, the biological function of GACAT3 in liver cancer remains unclear. The present study aimed to determine the expression level and function of GACAT3 in liver cancer. The authors cultured liver cancer cells in vitro and GACAT3 was silenced in the cells. Cell proliferation, apoptosis and migration were determined by MTT assay, flow cytometric analysis and transwell assay, respectively. It was demonstrated that GACAT3 was upregulated in liver cancer tissues. The inhibition of GACAT3 decreased the ability of hepatoma cells to proliferate and migrate, and increased apoptosis of the cells. These findings provide the first evidence, to the best of our knowledge, of the exact role of GACAT3 in liver cancer, suggesting GACAT3 as a potential target for liver cancer therapy in the future.
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1 

Forner A, Reig M and Bruix J: Hepatocellular carcinoma. Lancet. 391:1301–1314. 2018.PubMed/NCBI View Article : Google Scholar

2 

European Association For The Study Of The Liver and European Organisation For Research And Treatment Of Cancer: EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol 56: 908-943, 2012.

3 

Pollutri D, Gramantieri L, Bolondi L and Fornari F: TP53/MicroRNA interplay in hepatocellular carcinoma. Int J Mol Sci. 17(12)2016.PubMed/NCBI View Article : Google Scholar

4 

Bruix J, Takayama T, Mazzaferro V, Chau GY, Yang J, Kudo M, Cai J, Poon RT, Han KH, Tak WY, et al: Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): A phase 3, randomised, double-blind, placebo-controlled trial. Lancet Oncol. 16:1344–1354. 2015.PubMed/NCBI View Article : Google Scholar

5 

Akhade VS, Pal D and Kanduri C: Long noncoding RNA: Genome organization and mechanism of action. Adv Exp Med Biol. 1008:47–74. 2017.PubMed/NCBI View Article : Google Scholar

6 

Carpenter S and Fitzgerald KA: Cytokines and long noncoding RNAs. Cold Spring Harb Perspect Biol. 10(a028589)2018.PubMed/NCBI View Article : Google Scholar

7 

Kwok ZH and Tay Y: Long noncoding RNAs: Lincs between human health and disease. Biochem Soc Trans. 45:805–812. 2017.PubMed/NCBI View Article : Google Scholar

8 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017.PubMed/NCBI View Article : Google Scholar

9 

Wu X, Tudoran OM, Calin GA and Ivan M: The many faces of long noncoding RNAs in cancer. Antioxid Redox Signal. 20:922–935. 2017.PubMed/NCBI View Article : Google Scholar

10 

Cheetham SW, Gruhl F, Mattick JS and Dinger ME: Long noncoding RNAs and the genetics of cancer. Br J Cancer. 108:2419–2425. 2013.PubMed/NCBI View Article : Google Scholar

11 

Falcon T, Freitas M, Mello AC, Coutinho L, Alvares-da-Silva MR and Matte U: Analysis of the cancer genome atlas data reveals novel putative ncRNAs targets in hepatocellular carcinoma. Biomed Res Int. 26(2864120)2018.PubMed/NCBI View Article : Google Scholar

12 

Xie Z, Zhou F, Yang Y, Li L, Lei Y, Lin X, Li H, Pan X, Chen J, Wang G, et al: Lnc-PCDH9-13:1 is a hypersensitive and specific biomarker for early hepatocellular carcinoma. EBioMedicine. 33:57–67. 2018.PubMed/NCBI View Article : Google Scholar

13 

Shen W, Yuan Y, Zhao M, Li J, Xu J, Lou G, Zheng J, Bu S, Guo J and Xi Y: Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway. Tumour Biol. 37:14895–14902. 2016.PubMed/NCBI View Article : Google Scholar

14 

Feng L, Zhu Y, Zhang Y and Rao M: LncRNA GACAT3 promotes gastric cancer progression by negatively regulating miR-497 expression. Biomed Pharmacother. 97:136–142. 2018.PubMed/NCBI View Article : Google Scholar

15 

National Health and Family Planning Commission of the People's Republic of China: Diagnosis, treatment and treatment of hepatocellular carcinoma (V2017). J Clin Hepatol 33: 114-126, 2017.

16 

Xu C, Shao Y, Xia T, Yang Y, Dai J, Luo L, Zhang X, Sun W, Song H, Xiao B and Guo J: lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis. Tumour Biol. 35:9701–9706. 2014.PubMed/NCBI View Article : Google Scholar

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

18 

Gui Y and Zheng XL: Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. J Biol Chem. 278:53017–53025. 2003.PubMed/NCBI View Article : Google Scholar

19 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014.PubMed/NCBI View Article : Google Scholar

20 

Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL, Chen J, Liu X and Wang SK: Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget. 6:7899–7917. 2015.PubMed/NCBI View Article : Google Scholar

21 

Sui J, Yang X, Qi W, Guo K, Gao Z, Wang L and Sun D: Long non-coding RNA linc-USP16 functions as a tumour suppressor in hepatocellular carcinoma by regulating PTEN expression. Cell Physiol Biochem. 44:1188–1198. 2017.PubMed/NCBI View Article : Google Scholar

22 

Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M and Zatloukal K: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 132:330–342. 2007.PubMed/NCBI View Article : Google Scholar

23 

Zhong H, Yang J, Zhang B, Wang X, Pei L, Zhang L, Lin Z, Wang Y and Wang C: LncRNA GACAT3 predicts poor prognosis and promotes cell proliferation in breast cancer through regulation of miR-497/CCND2. Cancer Biomark. 22:787–797. 2018.PubMed/NCBI View Article : Google Scholar

24 

Zhou W, Wang L, Miao Y and Xing R: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. Onco Targets Ther. 11:1543–1552. 2018.PubMed/NCBI View Article : Google Scholar

25 

Yang X, Zhang W, Cheng SQ and Yang RL: High expression of lncRNA GACAT3 inhibits invasion and metastasis of non-small cell lung cancer to enhance the effect of radiotherapy. Eur Rev Med Pharmacol Sci. 22:1315–1322. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dong L, Zhu K, Chen M, Li D, Jiang C and Chen L: Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells. Exp Ther Med 19: 3377-3383, 2020.
APA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., & Chen, L. (2020). Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells. Experimental and Therapeutic Medicine, 19, 3377-3383. https://doi.org/10.3892/etm.2020.8604
MLA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19.5 (2020): 3377-3383.
Chicago
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3377-3383. https://doi.org/10.3892/etm.2020.8604
Copy and paste a formatted citation
x
Spandidos Publications style
Dong L, Zhu K, Chen M, Li D, Jiang C and Chen L: Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells. Exp Ther Med 19: 3377-3383, 2020.
APA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., & Chen, L. (2020). Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells. Experimental and Therapeutic Medicine, 19, 3377-3383. https://doi.org/10.3892/etm.2020.8604
MLA
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19.5 (2020): 3377-3383.
Chicago
Dong, L., Zhu, K., Chen, M., Li, D., Jiang, C., Chen, L."Long non‑coding RNA GACAT3 promotes liver cancer progression by regulating the proliferation, apoptosis and migration of tumor cells". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3377-3383. https://doi.org/10.3892/etm.2020.8604
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