Open Access

Effects of nanoparticle‑mediated delivery of pitavastatin on atherosclerotic plaques in ApoE‑knockout mice and THP‑1‑derived macrophages

  • Authors:
    • Yujiao Sun
    • Ling Chen
    • Shijie Zhao
    • Liye Shi
    • Hua Li
    • Wen Tian
    • Guoxian Qi
  • View Affiliations

  • Published online on: April 1, 2020     https://doi.org/10.3892/etm.2020.8632
  • Pages: 3787-3797
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The treatment of atherosclerosis remains complex. Pitavastatin serves an important role in the prevention and treatment of atherosclerosis. The present study aimed to investigate the effects of nanoparticle (NP)‑mediated delivery of pitavastatin into atherosclerotic plaques as a novel treatment method for atherosclerosis. The results of the present study demonstrated that pitavastatin‑NP was more effective in attenuating the size of atherosclerotic plaques and enhancing the stability of plaques in vitro compared with pitavastatin alone. In an apolipoprotein E (ApoE)‑knockout mouse model of atherosclerosis, a single intravenous injection of fluorescein isothiocyanate‑NP resulted in the delivery of NP into atherosclerotic plaques for up to 7 days post‑injection. In ApoE‑knockout mice and THP‑1‑derived macrophages, pitavastatin‑NP attenuated the development of atherosclerosis, which was associated with regulating lipid metabolism, and inhibited the secretion of inflammatory markers compared with pitavastatin alone. Additionally, the treatment advantages of pitavastatin‑NP were independent of lipid lowering. The results demonstrated that pitavastatin‑NP administration was more effective in attenuating the development of atherosclerotic plaques compared with systemic administration of pitavastatin.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sun Y, Chen L, Zhao S, Shi L, Li H, Tian W and Qi G: Effects of nanoparticle‑mediated delivery of pitavastatin on atherosclerotic plaques in ApoE‑knockout mice and THP‑1‑derived macrophages. Exp Ther Med 19: 3787-3797, 2020
APA
Sun, Y., Chen, L., Zhao, S., Shi, L., Li, H., Tian, W., & Qi, G. (2020). Effects of nanoparticle‑mediated delivery of pitavastatin on atherosclerotic plaques in ApoE‑knockout mice and THP‑1‑derived macrophages. Experimental and Therapeutic Medicine, 19, 3787-3797. https://doi.org/10.3892/etm.2020.8632
MLA
Sun, Y., Chen, L., Zhao, S., Shi, L., Li, H., Tian, W., Qi, G."Effects of nanoparticle‑mediated delivery of pitavastatin on atherosclerotic plaques in ApoE‑knockout mice and THP‑1‑derived macrophages". Experimental and Therapeutic Medicine 19.6 (2020): 3787-3797.
Chicago
Sun, Y., Chen, L., Zhao, S., Shi, L., Li, H., Tian, W., Qi, G."Effects of nanoparticle‑mediated delivery of pitavastatin on atherosclerotic plaques in ApoE‑knockout mice and THP‑1‑derived macrophages". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3787-3797. https://doi.org/10.3892/etm.2020.8632