Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2020 Volume 19 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2020 Volume 19 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner

  • Authors:
    • Yuxu Niu
    • Dongfang Tang
    • Liwen Fan
    • Wen Gao
    • Hui Lin
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Thoracic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3571-3580
    |
    Published online on: April 2, 2020
       https://doi.org/10.3892/etm.2020.8635
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic potential in non‑small cell lung cancer (NSCLC) remains unclear. In the present study, immunohistochemistry was used to detect the expression and localization of CCR9, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)‑1 and MMP‑7 in lung cancer tissue and adjacent normal tissue. The association between the expression of CCR9 and clinical variables was also examined. Reverse transcription‑quantitative PCR and western blotting were conducted to detect the expression of VEGF‑C, VEGF‑D, MMP‑1 and MMP‑7 in lung cancer cell lines (A549 and SK‑MES‑1). Migration and invasion assays were conducted to examine cell migration and invasion. Survival and mutation analysis were conducted using published datasets. The expressions of CCR9, VEGF, MMP‑1 and MMP‑7 were upregulated in cancer tissue, compared with adjacent normal tissue (all P<0.05). Patients with lower expression of CCR9 or CCL25 had better overall survival (OS) compared with those with higher CCR9 or CCL25 expression (P<0.05 and P=0.05, respectively). Furthermore, the expressions of VEGF‑C, VEGF‑D, MMP‑1 and MMP‑7 were higher in the CCL25‑treated cell lines (all P<0.05), but MMP‑7 protein expression was not affected by CCL25 treatment in SK‑MES‑1 cells (P>0.05). Following treatment with CCL25, lung cancer cells demonstrated higher migratory and invasive potential, which could be blocked by the CCR9 antibody (P<0.05). Survival analysis demonstrated that low expression levels of both CCR9 and CCL25 mRNA indicated favorable OS in patients with NSCLC. Altogether, these results suggested that CCL25 enhanced the phenotype associated with migration and invasion in NSCLC by regulating the expression of VEGF‑C, VEGF‑D, MMP‑1 and MMP‑7.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019.PubMed/NCBI View Article : Google Scholar

2 

Fidler IJ: Critical factors in the biology of human cancer metastasis: Twenty-eighth GHA Clowes memorial award lecture. Cancer Res. 50:6130–6138. 1990.PubMed/NCBI

3 

Fidler IJ: Critical determinants of cancer metastasis: Rationale for therapy. Cancer Chemother Pharmacol. 43 (43 Suppl):S3–S10. 1999.PubMed/NCBI View Article : Google Scholar

4 

Strieter RM: Chemokines: Not just leukocyte chemoattractants in the promotion of cancer. Nat Immunol. 2:285–286. 2001.PubMed/NCBI View Article : Google Scholar

5 

Stein JV and Nombela-Arrieta C: Chemokine control of lymphocyte trafficking: A general overview. Immunology. 116:1–12. 2005.PubMed/NCBI View Article : Google Scholar

6 

Olson TS and Ley K: Chemokines and chemokine receptors in leukocyte trafficking. Am J Physiol Regulatory Integrative Comparative Physiol. 283:R7–R28. 2002.PubMed/NCBI View Article : Google Scholar

7 

Saintigny P, Massarelli E, Lin S, Ahn YH, Chen Y, Goswami S and Zhang L: CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma. Cancer Res. 73:571–582. 2013.PubMed/NCBI View Article : Google Scholar

8 

Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R and Xiong S: Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res. 11:8273–8280. 2005.PubMed/NCBI View Article : Google Scholar

9 

Hald SM, Kiselev Y, Al-Saad S, Richardsen E, Johannessen C, Eilertsen M and Bremnes RM: Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: Combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival. BMC Cancer. 15(441)2015.PubMed/NCBI View Article : Google Scholar

10 

Mukaida N, Sasaki SI and Baba T: Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment. Mediators Inflamm. 2014(170381)2014.PubMed/NCBI View Article : Google Scholar

11 

Zhu YM, Webster SJ, Flower D and Woll PJ: Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br J Cancer. 91(1970)2004.PubMed/NCBI View Article : Google Scholar

12 

Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP and Strieter RM: The stromal derived factor-1/CXCL12–CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med. 167:1676–1686. 2003.PubMed/NCBI View Article : Google Scholar

13 

Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH and Singh S: CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis. Oncotarget. 5(10170)2014.PubMed/NCBI View Article : Google Scholar

14 

Li B, Wang Z, Zhong Y, Lan J, Li X and Lin H: CCR9-CCL25 interaction suppresses apoptosis of lung cancer cells by activating the PI3K/Akt pathway. Med Oncol. 32(66)2015.PubMed/NCBI View Article : Google Scholar

15 

Zhong Y, Jiang L, Lin H, Li B, Lan J, Liang S, Shen B, Lei Z and Zheng W: Expression of CC chemokine receptor 9 predicts poor prognosis in patients with lung adenocarcinoma. Diagn Pathol. 10(101)2015.PubMed/NCBI View Article : Google Scholar

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

17 

Győrffy B, Surowiak P, Budczies J and Lánczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 8(e82241)2013.PubMed/NCBI View Article : Google Scholar

18 

Campbell JD, Alexandrov A, Kim J, Wala J, Berger AH, Pedamallu CS and Imielinski M: Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 48(607)2016.PubMed/NCBI View Article : Google Scholar

19 

Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E and Sougnez C: Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 150:1107–1120. 2012.PubMed/NCBI View Article : Google Scholar

20 

Ellrott K, Bailey MH, Saksena G, Covington KR, Kandoth C, Stewart C and Sofia HJ: Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines. Cell Systems. 6:271–281. 2018.PubMed/NCBI View Article : Google Scholar

21 

Cancer Genome Atlas Research Network: Comprehensive genomic characterization of squamous cell lung cancers. Nature 489: 519, 2012.

22 

Skov BG, Høgdall E, Clementsen P, Krasnik M, Larsen KR, Sørensen JB and Mellemgaard A: The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population. APMIS. 123:108–115. 2015.PubMed/NCBI View Article : Google Scholar

23 

Shi Y, Li J, Zhang S, Wang M, Yang S, Li N and Zheng M: Molecular epidemiology of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology-Mainland China subset analysis of the PIONEER study. PLoS One. 10(e0143515)2015.PubMed/NCBI View Article : Google Scholar

24 

Hirsch FR and Bunn PA Jr: EGFR testing in lung cancer is ready for prime time. Lancet Oncol. 5:432–433. 2009.PubMed/NCBI View Article : Google Scholar

25 

Haratake N, Seto T, Takamori S, Toyozawa R, Nosaki K, Miura N, Ohba T, Toyokawa G, Taguchi K, Yamaguchi M, et al: Short progression-free survival of ALK inhibitors sensitive to secondary mutations in ALK-positive NSCLC patients. Thorac Cancer. 10:1779–1787. 2019.PubMed/NCBI View Article : Google Scholar

26 

Zlotnik A and Yoshie O: Chemokines: A new classification system and their role in immunity. Immunity. 12:121–127. 2000.PubMed/NCBI View Article : Google Scholar

27 

Nishikawa G, Kawada K, Nakagawa J, Toda K, Ogawa R, Inamoto S and Sakai Y: Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5. Cell Death Dis. 10(264)2019.PubMed/NCBI View Article : Google Scholar

28 

Zhu F, Liu Y, Liu L, Zhou Y, Zhou P, Yan Q and Ding S: CKLF1 enhances Inflammation-mediated carcinogenesis and prevents Doxorubicin-induced apoptosis via IL-6/STAT3 signaling in HCC. Clin Cancer Res. 25:4141–4154. 2019.

29 

Steele CW, Karim SA, Leach JD, Bailey P, Upstill-Goddard R, Rishi L and Eberlein C: CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell. 29:832–845. 2016.PubMed/NCBI View Article : Google Scholar

30 

Oonakahara KI, Matsuyama W, Higashimoto I, Kawabata M, Arimura K and Osame M: Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol. 30:671–677. 2004.PubMed/NCBI View Article : Google Scholar

31 

Yusen W, Xia W, Shengjun Y, Shaohui Z and Hongzhen Z: The expression and significance of tumor associated macrophages and CXCR4 in non-small cell lung cancer. J BUON. 23:398–402. 2018.PubMed/NCBI

32 

Choi YH, Burdick MD, Strieter BA, Mehrad B and Strieter RM: CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells. Mol Cancer Res. 12:38–47. 2014.PubMed/NCBI View Article : Google Scholar

33 

Siegel G, Malmsten M and Klüssendorf D: Tumor cell locomotion and metastatic spread. Microsc Res Tech. 43:276–282. 1998.PubMed/NCBI View Article : Google Scholar

34 

Navolotski A, Rumjnzev A, Lü H, Proft D, Bartholmes P and Zänker KS: Migration and gap junctional intercellular communication determine the metastatic phenotype of human tumor cell lines. Cancer Lett. 118:181–187. 1997.PubMed/NCBI View Article : Google Scholar

35 

Achen MG and Stacker SA: Molecular control of lymphatic metastasis. Ann N Y Acad Sci. 1131:225–234. 2008.PubMed/NCBI View Article : Google Scholar

36 

Yonemura Y, Endo Y, Tabata K, Kawamura T, Yun HY, Bandou E, Sasaki T and Miura M: Role of VEGF-C and VEGF-D in lymphangiogenesis in gastric cancer. Int J Clin Oncol. 10:318–327. 2005.PubMed/NCBI View Article : Google Scholar

37 

Marchiò S, Primo L, Pagano M, Palestro G, Albini A, Veikkola T, Cascone I, Alitalo K and Bussolino F: Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells. J Biol Chem. 274:27617–27622. 1999.PubMed/NCBI View Article : Google Scholar

38 

Timoshenko AV, Rastogi S and Lala PK: Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells. Br J Cancer. 97:1090–1098. 2007.PubMed/NCBI View Article : Google Scholar

39 

Zhao L, Zhu Z, Yao C, Huang Y, Zhi E, Chen H, Tian R, Li P, Yuan Q, Xue Y, et al: VEGFC/VEGFR3 signaling regulates mouse Spermatogonial cell proliferation via the activation of AKT/MAPK and cyclin D1 pathway and mediates the apoptosis by affecting caspase 3/9 and Bcl-2. Cell Cycle. 17:225–239. 2018.PubMed/NCBI View Article : Google Scholar

40 

Schmid MC and Varner JA: Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 250:1–8. 2007.PubMed/NCBI View Article : Google Scholar

41 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002.PubMed/NCBI View Article : Google Scholar

42 

Movahedi K, Laoui D, Gysemans C, Baeten M, Stangé G, Van den Bossche, Mack M, Pipeleers D, In't Veld P, De Baetselier P and Van Ginderachter JA: Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70:5728–5739. 2010.PubMed/NCBI View Article : Google Scholar

43 

Volk-Draper LD, Hall KL, Wilber AC and Ran S: Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS One. 12(e0179257)2017.PubMed/NCBI View Article : Google Scholar

44 

Alitalo A and Detmar M: Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene. 31(4499)2012.PubMed/NCBI View Article : Google Scholar

45 

Achen MG and Stacker SA: Vascular endothelial growth factor-D: Signaling mechanisms, biology, and clinical relevance. Growth Factors. 30:283–296. 2012.PubMed/NCBI View Article : Google Scholar

46 

Stacker SA, Achen MG, Jussila L, Baldwin ME and Alitalo K: Metastasis: Lymphangiogenesis and cancer metastasis. Nature Rev Cancer. 2(573)2002.PubMed/NCBI View Article : Google Scholar

47 

Chen Y, Liu Y, Wang Y, Li W, Wang X, Liu X, Chen Y, Ouyang C and Wang J: Quantification of STAT3 and VEGF expression for molecular diagnosis of lymph node metastasis in breast cancer. Medicine (Baltimore). 96(e8488)2017.PubMed/NCBI View Article : Google Scholar

48 

Guo J, Lou W, Ji Y and Zhang S: Effect of CCR7, CXCR4 and VEGF-C on the lymph node metastasis of human pancreatic ductal adenocarcinoma. Oncol Lett. 5:1572–1578. 2013.PubMed/NCBI View Article : Google Scholar

49 

Sánchez-Lorencio MI, Saenz L, Ramirez P, Villalba-López F, de la Orden V, Mediero-Valeros B, Revilla Nuin B, Gonzalez MR, Cascales-Campos PA, Ferreras-Martínez D, et al: Matrix metalloproteinase 1 as a novel biomarker for monitoring hepatocellular carcinoma in liver transplant patients. Transplant Proc. 50:623–627. 2018.PubMed/NCBI View Article : Google Scholar

50 

Gao Y, Nan X, Shi X, Mu X, Liu B, Zhu H, Yao B, Liu X, Yang T, Hu Y and Liu S: SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation. BMC Cancer. 19(685)2019.PubMed/NCBI View Article : Google Scholar

51 

Yokoi A, Yoshioka Y, Yamamoto Y, Ishikawa M, Ikeda SI, Kato T, Kiyono T, Takeshita F, Kajiyama H, Kikkawa F and Ochiya T: Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. Nat Commun. 8(14470)2017.PubMed/NCBI View Article : Google Scholar

52 

Sizemore ST, Sizemore GM, Booth CN, Thompson CL, Silverman P, Bebek G, Abdul-Karim FW, Avril S and Keri RA: Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors. Breast Cancer Res Treat. 146:25–40. 2014.PubMed/NCBI View Article : Google Scholar

53 

Yuan S, Lin LS, Gan RH, Huang L, Wu XT, Zhao Y, Su BH, Zheng D and Lu YG: Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma. BMC Cancer. 20(33)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Niu Y, Tang D, Fan L, Gao W and Lin H: CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Exp Ther Med 19: 3571-3580, 2020.
APA
Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and Therapeutic Medicine, 19, 3571-3580. https://doi.org/10.3892/etm.2020.8635
MLA
Niu, Y., Tang, D., Fan, L., Gao, W., Lin, H."CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner". Experimental and Therapeutic Medicine 19.6 (2020): 3571-3580.
Chicago
Niu, Y., Tang, D., Fan, L., Gao, W., Lin, H."CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3571-3580. https://doi.org/10.3892/etm.2020.8635
Copy and paste a formatted citation
x
Spandidos Publications style
Niu Y, Tang D, Fan L, Gao W and Lin H: CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Exp Ther Med 19: 3571-3580, 2020.
APA
Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and Therapeutic Medicine, 19, 3571-3580. https://doi.org/10.3892/etm.2020.8635
MLA
Niu, Y., Tang, D., Fan, L., Gao, W., Lin, H."CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner". Experimental and Therapeutic Medicine 19.6 (2020): 3571-3580.
Chicago
Niu, Y., Tang, D., Fan, L., Gao, W., Lin, H."CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3571-3580. https://doi.org/10.3892/etm.2020.8635
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team