Open Access

miR‑454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD

  • Authors:
    • Chaoqun Huang
    • Jiuyang Liu
    • Xuekai Pan
    • Chunwei Peng
    • Bin Xiong
    • Maohui Feng
    • Xiaojun Yang
  • View Affiliations

  • Published online on: April 9, 2020     https://doi.org/10.3892/etm.2020.8655
  • Pages: 3604-3610
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA‑454 (miR‑454), is involved in the progression of various types of cancers. The present study aimed to evaluate the effect of miR‑454 on the progression of gastric cancer. SGC‑7901 cells overexpressing or silencing miR454 were constructed via transfection and the survival rate of the cells was determined. The relationship between miR‑454 and cylindromatosis (CYLD) was explored and the influence of miR‑454 on oxaliplatin resistance was investigated in SGC‑7901 cells. It was determined that overexpression of miR‑454 increased the number of colonies and reduced apoptosis rate of SGC‑7901 cells. The CYLD gene was identified as a direct target of miR‑454. miR‑454 overexpression downregulated the expression of CYLD, leading to an increase in SGC‑7901 cell proliferation. Finally, miR‑454 was also demonstrated to induce resistance to oxaliplatin in gastric cancer cells. In conclusion, the present in vitro findings suggested that miR‑454 might be a novel therapeutic target for gastric cancer.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang C, Liu J, Pan X, Peng C, Xiong B, Feng M and Yang X: miR‑454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD. Exp Ther Med 19: 3604-3610, 2020.
APA
Huang, C., Liu, J., Pan, X., Peng, C., Xiong, B., Feng, M., & Yang, X. (2020). miR‑454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD. Experimental and Therapeutic Medicine, 19, 3604-3610. https://doi.org/10.3892/etm.2020.8655
MLA
Huang, C., Liu, J., Pan, X., Peng, C., Xiong, B., Feng, M., Yang, X."miR‑454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD". Experimental and Therapeutic Medicine 19.6 (2020): 3604-3610.
Chicago
Huang, C., Liu, J., Pan, X., Peng, C., Xiong, B., Feng, M., Yang, X."miR‑454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3604-3610. https://doi.org/10.3892/etm.2020.8655