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Article

Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome

  • Authors:
    • Alexandra Chira
    • Cornelia Braicu
    • Liviuta Budisan
    • Romeo Ioan Chira
    • Ioana Berindan‑Neagoe
    • Dan Lucian Dumitrascu
  • View Affiliations / Copyright

    Affiliations: Second Medical Clinic, Department of Internal Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania, Research Center for Functional Genomics, Biomedicine and Translational Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, First Medical Clinic, Division of Gastroenterology, Department of Internal Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania
  • Pages: 24-30
    |
    Published online on: April 15, 2020
       https://doi.org/10.3892/etm.2020.8665
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Abstract

Irritable bowel syndrome (IBS) is one the most frequent and common functional gastrointestinal disorders that has a multifactorial etiopathogenesis. Multiple biomarkers have been tested in search for a reliable and specific biomarker, but there is not yet a specific biomarker for IBS. The aim of this study was to evaluate two biomarkers of different putative pathways of the pathogenesis of IBS: the monocyte chemotactic protein‑1 (MCP‑1) and nitrotyrosine, in order to establish their role as potential biomarkers. We enrolled 42 consecutive IBS patients diagnosed by Rome III criteria and 35 consecutive healthy controls. Serum concentrations for the two biomarkers (MCP‑1 and nitrotyrosine) were determined using commercial ELISA kits. Serum levels of MCP‑1 were not statistically significantly higher in IBS patients than in controls (204±130 vs. 174±73 pg/ml; P=0.311). Nitrotyrosine levels were statistically significantly lower in IBS patients than in controls (30±12 vs. 353±14 nM; P=0.050). MCP‑1 levels were higher in IBS patients with metabolic syndrome versus IBS patients without metabolic syndrome (239±153 vs. 168±120 pg/ml; P=0.948) and in controls with metabolic syndrome (174±56 pg/ml). MCP‑1 serum levels were statistically significantly higher in IBS patients with metabolic syndrome than in controls (239±153 vs. 157±89 pg/ml; P=0.037), suggesting multiple factors being involved, particularly the diet and its relation with the metabolic syndrome, and it suggests that MCP‑1 could be a marker of subclinical atherosclerosis. Low‑grade inflammation might be related to oxidative stress, which plays an underestimated role in the pathogenesis of IBS.
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Copy and paste a formatted citation
Spandidos Publications style
Chira A, Braicu C, Budisan L, Chira RI, Berindan‑Neagoe I and Dumitrascu DL: Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome. Exp Ther Med 20: 24-30, 2020.
APA
Chira, A., Braicu, C., Budisan, L., Chira, R.I., Berindan‑Neagoe, I., & Dumitrascu, D.L. (2020). Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome. Experimental and Therapeutic Medicine, 20, 24-30. https://doi.org/10.3892/etm.2020.8665
MLA
Chira, A., Braicu, C., Budisan, L., Chira, R. I., Berindan‑Neagoe, I., Dumitrascu, D. L."Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome". Experimental and Therapeutic Medicine 20.1 (2020): 24-30.
Chicago
Chira, A., Braicu, C., Budisan, L., Chira, R. I., Berindan‑Neagoe, I., Dumitrascu, D. L."Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome". Experimental and Therapeutic Medicine 20, no. 1 (2020): 24-30. https://doi.org/10.3892/etm.2020.8665
Copy and paste a formatted citation
x
Spandidos Publications style
Chira A, Braicu C, Budisan L, Chira RI, Berindan‑Neagoe I and Dumitrascu DL: Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome. Exp Ther Med 20: 24-30, 2020.
APA
Chira, A., Braicu, C., Budisan, L., Chira, R.I., Berindan‑Neagoe, I., & Dumitrascu, D.L. (2020). Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome. Experimental and Therapeutic Medicine, 20, 24-30. https://doi.org/10.3892/etm.2020.8665
MLA
Chira, A., Braicu, C., Budisan, L., Chira, R. I., Berindan‑Neagoe, I., Dumitrascu, D. L."Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome". Experimental and Therapeutic Medicine 20.1 (2020): 24-30.
Chicago
Chira, A., Braicu, C., Budisan, L., Chira, R. I., Berindan‑Neagoe, I., Dumitrascu, D. L."Monocyte chemotactic protein‑1 and nitrotyrosine in irritable bowel syndrome". Experimental and Therapeutic Medicine 20, no. 1 (2020): 24-30. https://doi.org/10.3892/etm.2020.8665
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