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Article

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

  • Authors:
    • Da‑Sen Yuan
    • Yue‑Qi Huang
    • Yuan‑Ji Fu
    • Juan Xie
    • Yuan‑Lu Huang
    • Shi‑Shan Zhou
    • Pei‑Yuan Sun
    • Xiao‑Qing Tang
  • View Affiliations / Copyright

    Affiliations: Institute of Neuroscience, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 671-677
    |
    Published online on: April 23, 2020
       https://doi.org/10.3892/etm.2020.8680
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Abstract

Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate if not treated promptly. Previous studies have demonstrated the beneficial effects of hydrogen sulfide (H2S) on the brain and liver. The present study aimed to investigate the potential protective effects of H2S in ALF. A mouse model of ALF was established following treatment with thioacetamide (TAA). Mice with TAA‑induced ALF were intraperitoneally injected with 30 or 100 µmol/kg/day sodium hydrosulfide (NaHS; a H2S donor drug) for two weeks. According to results from novel object recognition and Y‑maze tests, in the present study, NaHS treatment alleviated cognitive deficiency and preserved spatial orientation learning ability in TAA‑induced ALF mice compared with those of untreated mice. In addition, NaHS treatment reduced serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and the concentration of ammonia compared with those that received control treatment, resulting in weight loss prevention. These findings suggested a beneficial effect of H2S on liver function. In conclusion, results from the present study suggested that H2S treatment may alleviate cognitive deficiency and hepatic dysfunction in mice with ALF, indicating the potential therapeutic benefits of applying H2S for the treatment of ALF.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan DS, Huang YQ, Fu YJ, Xie J, Huang YL, Zhou SS, Sun PY and Tang XQ: Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure. Exp Ther Med 20: 671-677, 2020.
APA
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S. ... Tang, X. (2020). Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure. Experimental and Therapeutic Medicine, 20, 671-677. https://doi.org/10.3892/etm.2020.8680
MLA
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S., Sun, P., Tang, X."Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure". Experimental and Therapeutic Medicine 20.1 (2020): 671-677.
Chicago
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S., Sun, P., Tang, X."Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure". Experimental and Therapeutic Medicine 20, no. 1 (2020): 671-677. https://doi.org/10.3892/etm.2020.8680
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan DS, Huang YQ, Fu YJ, Xie J, Huang YL, Zhou SS, Sun PY and Tang XQ: Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure. Exp Ther Med 20: 671-677, 2020.
APA
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S. ... Tang, X. (2020). Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure. Experimental and Therapeutic Medicine, 20, 671-677. https://doi.org/10.3892/etm.2020.8680
MLA
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S., Sun, P., Tang, X."Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure". Experimental and Therapeutic Medicine 20.1 (2020): 671-677.
Chicago
Yuan, D., Huang, Y., Fu, Y., Xie, J., Huang, Y., Zhou, S., Sun, P., Tang, X."Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure". Experimental and Therapeutic Medicine 20, no. 1 (2020): 671-677. https://doi.org/10.3892/etm.2020.8680
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