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Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma

  • Authors:
    • Huiwu Li
    • Hui Li
    • Yibulayin Waresijiang
    • Yan Chen
    • Ying Li
    • Liang Yu
    • Yike Li
    • Ling Liu
  • View Affiliations / Copyright

    Affiliations: Medical Research Center, Yubei People's Hospital, Shantou University, Shaoguan, Guangdong 512025, P.R. China, Department of Central Laboratory, Xinjiang Medical University, Xinshi, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, Department of Thoracic Surgery, Affiliated Cancer Hospital, Xinjiang Medical University, Xinshi, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, Department of Basic Medical College, Xinjiang Medical University, Xinshi, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, First Clinical Medical College, Xinjiang Medical University, Xinshi, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 315-324
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    Published online on: April 29, 2020
       https://doi.org/10.3892/etm.2020.8697
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Abstract

The present study analyzed the expression of the histone deacetylase (HDAC) 1, 2 and 3 in primary esophageal squamous cell carcinoma (ESCC) samples and how their levels correlate with clinicopathological parameters. ESCC patients (n=88) in the present study had received no previous treatment before undergoing surgical excision. The mRNA expression of HDAC1, ‑2 and ‑3 were detected by semi‑quantified PCR in ESCC samples and distal normal samples. The relationship of HDAC1, ‑2 and ‑3 expression with clinicopathological parameters was analyzed by χ2 test. The correlation among these HDACs was analyzed by Pearson's correlation test. Compared with distal normal tissues, ESCC samples had higher expression of HDAC1, but not HDAC2 or HDAC3 (P<0.05). The expression of HDACs was different between Kazak and Han ethnicities. The expression of HDAC2 was correlated with invasion depth (P<0.05), but not with sex, age, metastasis, or the degree of tumor differentiation (P>0.05). There was no association between HDAC1 or HDAC3 and clinicopathological parameters (P>0.05). For the Kazak and Han ethnicities, HDAC1 expression was present in male patients, patients with well/moderate differentiated ESCC and T3 and T4 ESCC (P<0.01). HDAC1 in patients aged <60 was associated with ethnicity (P<0.05). HDAC2 expression was different in positive LN metastasis, well/moderate differentiation and T3 and T4 ESCC (P<0.01). HDAC3 expression in male patients, patients with negative LN metastasis and well/moderate differentiation ESCC was associated with ethnicity (P<0.05). Additionally, the expression levels of HDAC1, ‑2 and ‑3 did not correlate with each other. Thus, HDAC1 expression may be used as a risk factor for ESCC and HDAC2 levels may be used to predict invasion depth. The expression of HDAC1, ‑2 and ‑3 has ethnic differences.
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Spandidos Publications style
Li H, Li H, Waresijiang Y, Chen Y, Li Y, Yu L, Li Y and Liu L: Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma. Exp Ther Med 20: 315-324, 2020.
APA
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L. ... Liu, L. (2020). Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 20, 315-324. https://doi.org/10.3892/etm.2020.8697
MLA
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L., Li, Y., Liu, L."Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 20.1 (2020): 315-324.
Chicago
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L., Li, Y., Liu, L."Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 20, no. 1 (2020): 315-324. https://doi.org/10.3892/etm.2020.8697
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Spandidos Publications style
Li H, Li H, Waresijiang Y, Chen Y, Li Y, Yu L, Li Y and Liu L: Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma. Exp Ther Med 20: 315-324, 2020.
APA
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L. ... Liu, L. (2020). Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 20, 315-324. https://doi.org/10.3892/etm.2020.8697
MLA
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L., Li, Y., Liu, L."Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 20.1 (2020): 315-324.
Chicago
Li, H., Li, H., Waresijiang, Y., Chen, Y., Li, Y., Yu, L., Li, Y., Liu, L."Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 20, no. 1 (2020): 315-324. https://doi.org/10.3892/etm.2020.8697
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