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gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells

  • Authors:
    • Xinheng Zhang
    • Zhihong Liao
    • Yu Wu
    • Yiming Yan
    • Sheng  Chen
    • Shaoli Lin
    • Feng Chen
    • Qingmei Xie
  • View Affiliations / Copyright

    Affiliations: Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, P.R. China, Molecular Virology Laboratory, Virginia‑Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 530-542
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    Published online on: May 4, 2020
       https://doi.org/10.3892/etm.2020.8711
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Abstract

MicroRNAs (miRNAs/miRs) serve a key role in regulating the cell cycle and inducing tumorigenesis. Subgroup J of the avian leukosis virus (ALV‑J) belongs to the family Retroviridae, subfamily Orthoretrovirinae and genus Alpharetrovirus that causes tumors in susceptible chickens. gga‑miR‑375 is downregulated and Yes‑associated protein 1 (YAP1) is upregulated in ALV‑J‑induced tumors in the livers of chickens, and it has been further identified that YAP1 is the direct target gene of gga‑miR‑375. In the present study, it was found that ALV‑J infection promoted the cell cycle and proliferation in DF‑1 cells. As the cell cycle and cell proliferation are closely associated with tumorigenesis, further experiments were performed to determine whether gga‑miR‑375 and YAP1 were involved in these cellular processes. It was demonstrated that gga‑miR‑375 significantly inhibited the cell cycle by inhibiting G1 to S/G2 stage transition and decreasing cell proliferation, while YAP1 significantly promoted the cell cycle and proliferation. Furthermore, these cellular processes in DF‑1 cells were affected by gga‑miR‑375 through the targeting of YAP1. Collectively, the present results suggested that gga‑miR‑375, downregulated by ALV‑J infection, negatively regulated the cell cycle and proliferation via the targeting of YAP1.
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1 

Indiková I, Much P, Stipkovits L, Siebert-Gulle K, Szostak MP, Rosengarten R and Citti C: Role of the GapA and CrmA cytadhesins of mycoplasma gallisepticum in promoting virulence and host colonization. Infect Immun. 81:1618–1624. 2013.PubMed/NCBI View Article : Google Scholar

2 

Jenkins C, Geary SJ, Gladd M and Djordjevic SP: The mycoplasma gallisepticum OsmC-like protein MG1142 resides on the cell surface and binds heparin. Microbiology. 153:1455–1463. 2007.PubMed/NCBI View Article : Google Scholar

3 

Kato M and Slack FJ: microRNAs: Small molecules with big roles-C. elegans to human cancer. Biol Cell. 100:71–81. 2008.PubMed/NCBI View Article : Google Scholar

4 

Zhao Y, Wang Z, Hou Y, Zhang K and Peng X: gga-miR-99a targets SMARCA5 to regulate mycoplasma gallisepticum (HS strain) infection by depressing cell proliferation in chicken. Gene. 627:239–247. 2017.PubMed/NCBI View Article : Google Scholar

5 

Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P and Stoffel M: A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 432:226–230. 2004.PubMed/NCBI View Article : Google Scholar

6 

Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J and Zhou T: MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res. 20:784–793. 2010.PubMed/NCBI View Article : Google Scholar

7 

Wang P, Xu LL, Li L, Ren S, Tang J, Zhang M and Xu M: The microRNA-375 as a potentially promising biomarker to predict the prognosis of patients with head and neck or esophageal squamous cell carcinoma: A meta-analysis. Eur Arch Otorhinolaryngol. 276:957–968. 2019.PubMed/NCBI View Article : Google Scholar

8 

Winther M, Alsner J, Tramm T, Baeksgaard L, Holtved E and Nordsmark M: Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer. Acta Oncol. 54:1582–1591. 2015.PubMed/NCBI View Article : Google Scholar

9 

Fan YP, Liao JZ, Lu YQ, Tian DA, Ye F, Zhao PX, Xiang GY, Tang WX and He XX: MiR-375 and doxorubicin co-delivered by liposomes for combination therapy of hepatocellular carcinoma. Mol Ther-Nucleic Acids. 7:181–189. 2017.PubMed/NCBI View Article : Google Scholar

10 

He J, Xie G, Tong J, Peng Y, Huang H, Li J, Wang N and Liang H: Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. Cell Biochem Biophys. 70:1343–1350. 2014.PubMed/NCBI View Article : Google Scholar

11 

Shaker OG, Mohammed SR, Mohammed AM and Mahmoud Z: Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer. J Clin Lab Anal. 32:2018.PubMed/NCBI View Article : Google Scholar

12 

Cheng Z, Liu J, Cui Z and Zhang L: Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China. J Vet Med Sci. 72:1027–1033. 2010.PubMed/NCBI View Article : Google Scholar

13 

Payne LN, Howes K, Gillespie AM and Smith LM: Host range of Rous sarcoma virus pseudotype RSV(HPRS-103) in 12 avian species: Support for a new avian retrovirus envelope subgroup, designated J. J Gen Virol. 73:2995–2997. 1992.PubMed/NCBI View Article : Google Scholar

14 

Meng F, Li Q, Zhang Y, Cui Z, Chang S and Zhao P: Isolation and characterization of subgroup J Avian Leukosis virus associated with hemangioma in commercial Hy-Line chickens. Poult Sci. 97:2667–2674. 2018.PubMed/NCBI View Article : Google Scholar

15 

Liang X, Gu Y, Chen X, Li T, Gao Y, Wang X, Fang C, Fang S and Yang Y: Identification and characterization of a novel natural recombinant avian leucosis virus from Chinese indigenous chicken flock. Virus Genes. 55:726–733. 2019.PubMed/NCBI View Article : Google Scholar

16 

Li X, Lin W, Chang S, Zhao P, Zhang X, Liu Y, Chen W, Li B, Shu D, Zhang H, et al: Isolation, identification and evolution analysis of a novel subgroup of avian leukosis virus isolated from a local Chinese yellow broiler in south China. Arch Virol. 161:2717–2725. 2016.PubMed/NCBI View Article : Google Scholar

17 

Meng F, Li Q, Zhang Y, Zhang Z, Tian S, Cui Z, Chang S and Zhao P: Characterization of subgroup J avian Leukosis virus isolated from Chinese indigenous chickens. Virol J. 15(33)2018.PubMed/NCBI View Article : Google Scholar

18 

Li H, Shang H, Shu D, Zhang H, Ji J, Sun B, Li H and Xie Q: gga-miR-375 plays a key role in tumorigenesis post subgroup J Avian Leukosis virus infection. PLos One. 9:2014.PubMed/NCBI View Article : Google Scholar

19 

Wang D, He J, Dong J, Meyer TF and Xu T: The HIPPO pathway in gynecological malignancies. Am J Cancer Res. 10:610–629. 2020.PubMed/NCBI

20 

Ma Y, Yang Y, Wang F, Wei Q and Qin H: Hippo-YAP signaling pathway: A new paradigm for cancer therapy. Int J Cancer. 137:2275–2286. 2015.PubMed/NCBI View Article : Google Scholar

21 

Johnson R and Halder G: The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov. 13:63–79. 2014.PubMed/NCBI View Article : Google Scholar

22 

Bao YJ, Hata Y, Ikeda M and Withanage K: Mammalian Hippo pathway: From development to cancer and beyond. J Biochem. 149:361–379. 2011.PubMed/NCBI View Article : Google Scholar

23 

Machado-Neto JA, Lazarini M, Favaro P, Franchi-GC Jr, Nowill AE, Saad ST and Traina F: ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Exp Cell Res. 324:137–145. 2014.PubMed/NCBI View Article : Google Scholar

24 

Edgar BA: From cell structure to transcription: Hippo forges a new path. Cell. 124:267–273. 2006.PubMed/NCBI View Article : Google Scholar

25 

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, et al: Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Sci Signal. 8(ra98)2015.PubMed/NCBI View Article : Google Scholar

26 

Wang H, Du YC, Zhou XJ, Liu H and Tang SC: The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy. Cancer Metastasis Rev. 33:173–181. 2014.PubMed/NCBI View Article : Google Scholar

27 

Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H and Sekido Y: YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene. 31:5117–5122. 2012.PubMed/NCBI View Article : Google Scholar

28 

Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS and Haber DA: Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA. 103:12405–12410. 2006.PubMed/NCBI View Article : Google Scholar

29 

Zhang X, Yan Y, Lin W, Li A, Zhang H, Lei X, Dai Z, Li X, Li H, Chen W, et al: Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition. RNA Biol. 16:118–132. 2019.PubMed/NCBI View Article : Google Scholar

30 

Frampton D, Schwenzer H, Marino G, Butcher LM, Pollara G, Kriston-Vizi J, Venturini C, Austin R, de-Castro KF, Ketteler R, et al: Molecular signatures of regression of the canine transmissible venereal tumor. Cancer Cell. 33(620-633.e6)2018.PubMed/NCBI View Article : Google Scholar

31 

Morgan TM, Mehra R, Tiemeny P, Wolf JS, Wu S, Sangale Z, Brawer M, Stone S, Wu CL and Feldman AS: A multigene signature based on cell cycle proliferation improves prediction of mortality within 5 yr of radical nephrectomy for renal cell carcinoma. Eur Urol. 73:763–769. 2018.PubMed/NCBI View Article : Google Scholar

32 

Sun F, Zhang Y, Xu L, Li S, Chen X, Zhang L, Wu Y and Li J: Proteasome inhibitor MG132 enhances cisplatin-induced apoptosis in osteosarcoma cells and inhibits tumor growth. Oncol Res. 26:655–664. 2018.PubMed/NCBI View Article : Google Scholar

33 

Zhu Y, Gu J, Li Y, Peng C, Shi M, Wang X, Wei G, Ge O, Wang D, Zhang B, et al: MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes. Cancer Lett. 412:59–68. 2018.PubMed/NCBI View Article : Google Scholar

34 

Liao Z, Dai Z, Cai C, Zhang X, Li A, Zhang H, Yan Y, Lin W, Wu Y, Li H, et al: Knockout of Atg5 inhibits proliferation and promotes apoptosis of DF-1 cells. In Vitro Cell Dev Biol Anim. 55:341–348. 2019.PubMed/NCBI View Article : Google Scholar

35 

Giotis ES, Ross CS, Robey RC, Nohturfft A, Goodbourn S and Skinner MA: Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells. Sci Rep. 7(17485)2017.PubMed/NCBI View Article : Google Scholar

36 

Abu-Bonsrah KD, Zhang D and Newgreen DF: CRISPR/Cas9 targets chicken embryonic somatic cells in vitro and in vivo and generates phenotypic abnormalities. Sci Rep. 6(34524)2016. View Article : Google Scholar

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

38 

Warren JSA, Xiao YX and Lamar JM: YAP/TAZ activation as a target for treating metastatic cancer. Cancers. 10:2018.PubMed/NCBI View Article : Google Scholar

39 

Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H and Hong W: The Hippo pathway in biological control and cancer development. J Cell Physiol. 226:928–939. 2011.PubMed/NCBI View Article : Google Scholar

40 

Zhang Y, Guan X, Chen Z, Cao D, Kang Z, Shen Q, Lei Q, Li F, Li H, Leghari MF, et al: The high conserved cellular receptors of avian leukosis virus subgroup J in Chinese local chickens contributes to its wide host range. Poult Sci. 97:4187–4192. 2018.PubMed/NCBI View Article : Google Scholar

41 

Ross CL, Kaushik S, Valdes-Rodriguez R and Anvekar R: MicroRNAs in cutaneous melanoma: Role as diagnostic and prognostic biomarkers. J Cell Physiol. 233:5133–5141. 2018.PubMed/NCBI View Article : Google Scholar

42 

Panagiotakopoulou M, Lendenmann T, Pramotton FM, Giampietro C, Stefopoulos G, Poulikakos D and Ferrari A: Cell cycle-dependent force transmission in cancer cells. Mol Biol Cell. 29:2528–2539. 2018.PubMed/NCBI View Article : Google Scholar

43 

Chen BW, Chen W, Liang H, Liu H, Liang C, Zhi X, Hu LQ, Yu XZ, Wei T, Ma T, et al: Inhibition of mTORC2 induces cell-cycle arrest and enhances the cytotoxicity of doxorubicin by suppressing MDR1 expression in HCC cells. Mol Cancer Ther. 14:1805–1815. 2015.PubMed/NCBI View Article : Google Scholar

44 

Li JL, Fu FQ, Wan XC, Huang SS, Wu DL and Li Y: Up-regulated miR-29c inhibits cell proliferation and glycolysis by inhibiting SLC2A3 expression in prostate cancer. Gene. 665:26–34. 2018.PubMed/NCBI View Article : Google Scholar

45 

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS and Johnson JM: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. 2005.PubMed/NCBI View Article : Google Scholar

46 

Chen J: The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression. Cold Spring Harb Perspect Med. 6(a026104)2016.PubMed/NCBI View Article : Google Scholar

47 

Li H, Ji J, Xie Q, Shang H, Zhang H, Xin X, Chen F, Sun B, Xue C, Ma J and Bi Y: Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus. Virus Res. 169:268–271. 2012. View Article : Google Scholar

48 

Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR and Camargo FD: Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell. 144:782–795. 2011.PubMed/NCBI View Article : Google Scholar

49 

von Gise A, Lin ZQ, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD and Pu WT: YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci USA. 109:2394–2399. 2012.PubMed/NCBI View Article : Google Scholar

50 

Yang Z, Zhang M, Xu K, Liu L, Hou WK, Cai YZ, Xu P and Yao JF: Knockdown of YAP1 inhibits the proliferation of osteosarcoma cells in vitro and in vivo. Oncol Rep. 32:1265–1272. 2014.PubMed/NCBI View Article : Google Scholar

51 

Oak C, Khalifa AO, Isali I, Bhaskaran N, Walker E and Shukla S: Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest. Int J Oncol. 53:835–843. 2018.PubMed/NCBI View Article : Google Scholar

52 

Lu HF, Chen YS, Yang JS, Chen JC, Lu KW, Chiu TH, Liu KC, Yeh CC, Chen GW, Lin HJ and Chung JG: Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells. In Vivo. 22:215–221. 2008. View Article : Google Scholar

53 

Qie S and Diehl JA: Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl). 94:1313–1326. 2016.PubMed/NCBI View Article : Google Scholar

54 

Luhtala S, Staff S, Tanner M and Isola J: Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer. Tumour Biol. 37:9813–9823. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Liao Z, Wu Y, Yan Y, Chen S, Lin S, Chen F and Xie Q: gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells. Exp Ther Med 20: 530-542, 2020.
APA
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S. ... Xie, Q. (2020). gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells. Experimental and Therapeutic Medicine, 20, 530-542. https://doi.org/10.3892/etm.2020.8711
MLA
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S., Chen, F., Xie, Q."gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells". Experimental and Therapeutic Medicine 20.1 (2020): 530-542.
Chicago
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S., Chen, F., Xie, Q."gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells". Experimental and Therapeutic Medicine 20, no. 1 (2020): 530-542. https://doi.org/10.3892/etm.2020.8711
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Liao Z, Wu Y, Yan Y, Chen S, Lin S, Chen F and Xie Q: gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells. Exp Ther Med 20: 530-542, 2020.
APA
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S. ... Xie, Q. (2020). gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells. Experimental and Therapeutic Medicine, 20, 530-542. https://doi.org/10.3892/etm.2020.8711
MLA
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S., Chen, F., Xie, Q."gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells". Experimental and Therapeutic Medicine 20.1 (2020): 530-542.
Chicago
Zhang, X., Liao, Z., Wu, Y., Yan, Y., Chen, S., Lin, S., Chen, F., Xie, Q."gga‑microRNA‑375 negatively regulates the cell cycle and proliferation by targeting Yes‑associated protein 1 in DF‑1 cells". Experimental and Therapeutic Medicine 20, no. 1 (2020): 530-542. https://doi.org/10.3892/etm.2020.8711
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