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Article Open Access

Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation

  • Authors:
    • Hengyi Liang
    • Yuqi Cui
    • Haoran Bu
    • Hang Liu
    • Pengcheng Yan
    • Lianqun Cui
    • Liming Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Deparment of Cardiology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450014, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 211-218
    |
    Published online on: May 6, 2020
       https://doi.org/10.3892/etm.2020.8721
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Abstract

In-stent restenosis (ISR) after drug‑eluting stent (DES) placement has recently emerged as a major concern for cardiologists. Identification of biomarkers to predict ISR may be invaluable for tailored management strategies. The present study aimed to evaluate the prognostic utility of circulating S100 calcium‑binding protein A12 (S100A12) for ISR. Out of 2,443 patients with DES‑based percutaneous coronary intervention (PCI) and follow‑up angiography at ~1 year after DES‑based PCI, 258 patients were diagnosed with ISR and 258 patients without ISR were randomly selected as controls. Serum S100A12 levels were determined in the two subsets on admission. The association between ISR and the circulating levels of S100A12 was determined by constructing two multivariate stepwise logistic regression models. In addition, S100A12 was assessed for its ability to predict ISR using receiver operating characteristic (ROC) curve analysis. The serum levels of S100A12 at baseline were significantly elevated in patients in the ISR group compared with those in the non‑ISR group (P<0.001). In the multivariate logistic regression analysis, after adjusting for conventional cardiovascular risk factors, laboratory parameters and medication after the procedure, the S100A12 level was revealed to be independently associated with ISR. When a cut‑off for serum S100A12 levels of 34.75 ng/ml was used, the ROC curve was able to predict ISR with 72.8% sensitivity and 79.1% specificity, and the area under the ROC curve was 0.796 (95% CI: 0.757 to 0.834, P<0.001). Furthermore, addition of S100A12 to established risk factors significantly improved the predictive power of reference models for ISR. S100A12 may serve as an independent marker to predict ISR in patients undergoing coronary DES implantation.
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1 

Bague N, Nasr B, Chaillou P, Costargent A, Gouailler-Vulcain F and Goueffic Y: The role for DCBs in the treatment of ISR. J Cardiovasc Surg (Torino). 57:578–585. 2016.PubMed/NCBI

2 

Kang IS, Shehata I, Shin DH, Kim JS, Kim BK, Ko YG, Choi D, Jang Y and Hong MK: Comparison between drug-coated balloon angioplasty and second-generation drug-eluting stent placement for the treatment of in-stent restenosis after drug-eluting stent implantation. Heart Vessels. 31:1405–1411. 2016.PubMed/NCBI View Article : Google Scholar

3 

Baumann F, Willenberg T, Do DD, Keo HH, Baumgartner I and Diehm N: Endovascular revascularization of below-the-knee arteries: Prospective short-term angiographic and clinical follow-up. J Vasc Interv Radiol. 22:1665–1673. 2011.PubMed/NCBI View Article : Google Scholar

4 

He YH, Wang XQ, Zhang J, Liu ZH, Pan WQ, Shen Y, Zhu ZB, Wang LJ, Yan XX, Yang K, et al: Association of serum HMGB2 levels with in-stent restenosis: HMGB2 promotes neointimal hyperplasia in mice with femoral artery injury and proliferation and migration of VSMCs. Arterioscler Thromb Vasc Biol. 37:717–729. 2017.PubMed/NCBI View Article : Google Scholar

5 

Montone RA, Sabato V, Sgueglia GA and Niccoli G: Inflammatory mechanisms of adverse reactions to drug-eluting stents. Curr Vasc Pharmacol. 11:392–398. 2013.PubMed/NCBI View Article : Google Scholar

6 

Wang Z, Zhang T, Sun L, Li R, Wei Y, Fan X, Yuan Z, Liu J and Chen T: Pioglitazone attenuates drug-eluting stent-induced proinflammatory state in patients by blocking ubiquitination of PPAR. PPAR Res. 2016(7407153)2016.PubMed/NCBI View Article : Google Scholar

7 

Foell D, Wittkowski H, Vogl T and Roth J: S100 proteins expressed in phagocytes: A novel group of damage-associated molecular pattern molecules. J Leukoc Biol. 81:28–37. 2007.PubMed/NCBI View Article : Google Scholar

8 

Farokhzadian J, Mangolian Shahrbabaki P and Bagheri V: S100A12-CD36 axis: A novel player in the pathogenesis of atherosclerosis? Cytokine. 122(154104)2019.PubMed/NCBI View Article : Google Scholar

9 

Bagheri V: S100A12: Friend or foe in pulmonary tuberculosis? Cytokine. 92:80–82. 2017.PubMed/NCBI View Article : Google Scholar

10 

Han EC, Cho SB, Ahn KJ, Oh SH, Kim J, Kim DS, Lee KH and Bang D: Expression of pro-inflammatory protein S100A12 (EN-RAGE) in behcet's disease and its association with disease activity: A pilot study. Ann Dermatol. 23:313–320. 2011.PubMed/NCBI View Article : Google Scholar

11 

Oesterle A and Bowman MA: S100A12 and the S100/calgranulins: Emerging biomarkers for atherosclerosis and possibly therapeutic targets. Arterioscler Thromb Vasc Boil. 35:2496–2507. 2015.PubMed/NCBI View Article : Google Scholar

12 

Leach ST, Yang Z, Messina I, Song C, Geczy CL, Cunningham AM and Day AS: Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease. Scand J Gastroenterol. 42:1321–1331. 2007.PubMed/NCBI View Article : Google Scholar

13 

Yan WX, Armishaw C, Goyette J, Yang Z, Cai H, Alewood P and Geczy CL: Mast cell and monocyte recruitment by S100A12 and its hinge domain. J Biol Chem. 283:13035–13043. 2008.PubMed/NCBI View Article : Google Scholar

14 

Hofmann Bowman MA, Gawdzik J, Bukhari U, Husain AN, Toth PT, Kim G, Earley J and McNally EM: S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol. 31:337–344. 2011.PubMed/NCBI View Article : Google Scholar

15 

Burke AP, Kolodgie FD, Zieske A, Fowler DR, Weber DK, Varghese PJ, Farb A and Virmani R: Morphologic findings of coronary atherosclerotic plaques in diabetics: A postmortem study. Arterioscler Thromb Vasc Boil. 24:1266–1271. 2004.PubMed/NCBI View Article : Google Scholar

16 

Mahajan N, Malik N, Bahl A and Dhawan V: Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease. Atherosclerosis. 207:597–602. 2009.PubMed/NCBI View Article : Google Scholar

17 

Ligthart S, Sedaghat S, Ikram MA, Hofman A, Franco OH and Dehghan A: EN-RAGE: A novel inflammatory marker for incident coronary heart disease. Arterioscler Thromb Vasc Biol. 34:2695–2699. 2014.PubMed/NCBI View Article : Google Scholar

18 

Saito T, Hojo Y, Ogoyama Y, Hirose M, Ikemoto T, Katsuki T, Shimada K and Kario K: S100A12 as a marker to predict cardiovascular events in patients with chronic coronary artery disease. Circ J. 76:2647–2652. 2012.PubMed/NCBI View Article : Google Scholar

19 

Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, et al: 2018 ESC/ESH guidelines for the management of arterial hypertension. Kardiol Pol. 77:71–159. 2019.PubMed/NCBI View Article : Google Scholar : (In Polish).

20 

Introduction: Standards of medical care in diabetes-2019. Diabetes Care. 42 (Suppl 1):S1–S2. 2019.PubMed/NCBI View Article : Google Scholar

21 

National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 106:3143–3421. 2002.PubMed/NCBI

22 

Schillinger M, Exner M, Mlekusch W, Rumpold H, Ahmadi R, Sabeti S, Haumer M, Wagner O and Minar E: Vascular inflammation and percutaneous transluminal angioplasty of the femoropopliteal artery: Association with restenosis. Radiology. 225:21–26. 2002.PubMed/NCBI View Article : Google Scholar

23 

Buyukterzi Z, Can U, Alpaydin S, Guzelant A, Karaarslan S, Kocyigit D and Gurses KM: Enhanced S100A9 and S100A12 expression in acute coronary syndrome. Biomark Med. 11:229–237. 2017.PubMed/NCBI View Article : Google Scholar

24 

Zhao P, Wu M, Yu H, Huang Y, Wang Y, Wang W and Yin W: Serum S100A12 levels are correlated with the presence and severity of coronary artery disease in patients with type 2 diabetes mellitus. J Investig Med. 61:861–866. 2013.PubMed/NCBI View Article : Google Scholar

25 

Schillinger M, Exner M, Mlekusch W, Haumer M, Rumpold H, Ahmadi R, Sabeti S, Wagner O and Minar E: Endovascular revascularization below the knee: 6-month results and predictive value of C-reactive protein level. Radiology. 227:419–425. 2003.PubMed/NCBI View Article : Google Scholar

26 

Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, et al: Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 153:425–434. 2010.PubMed/NCBI View Article : Google Scholar

27 

Liu J, Ren YG, Zhang LH, Tong YW and Kang L: Serum S100A12 concentrations are correlated with angiographic coronary lesion complexity in patients with coronary artery disease. Scand J Clin Lab Investig. 74:149–154. 2014.PubMed/NCBI View Article : Google Scholar

28 

Li H and Sun B: Toll-like receptor 4 in atherosclerosis. J Cell Mol Med. 11:88–95. 2007.PubMed/NCBI View Article : Google Scholar

29 

Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, et al: RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides. Cell. 97:889–901. 1999.PubMed/NCBI View Article : Google Scholar

30 

Rahel BM, Visseren FL, Suttorp MJ, Plokker TH, Kelder JC, de Jongh BM, Bouter KP and Diepersloot RJ: Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention. Cardiovasc Res. 60:136–140. 2003.PubMed/NCBI View Article : Google Scholar

31 

Yang Z, Tao T, Raftery MJ, Youssef P, Di Girolamo N and Geczy CL: Proinflammatory properties of the human S100 protein S100A12. J Leukoc Biol. 69:986–994. 2001.PubMed/NCBI

32 

Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, et al: Hck/Fgr kinase deficiency reduces plaque growth and stability by blunting monocyte recruitment and intraplaque motility. Circulation. 132:490–501. 2015.PubMed/NCBI View Article : Google Scholar

33 

Gallo G, Pierelli G, Forte M, Coluccia R, Volpe M and Rubattu S: Role of oxidative stress in the process of vascular remodeling following coronary revascularization. Int J Cardiol. 268:27–33. 2018.PubMed/NCBI View Article : Google Scholar

34 

Tardif MR, Chapeton-Montes JA, Posvandzic A, Page N, Gilbert C and Tessier PA: Secretion of S100A8, S100A9, and S100A12 by neutrophils involves reactive oxygen species and potassium efflux. J Immunol Res. 2015(296149)2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liang H, Cui Y, Bu H, Liu H, Yan P, Cui L and Chen L: Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation. Exp Ther Med 20: 211-218, 2020.
APA
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., & Chen, L. (2020). Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation. Experimental and Therapeutic Medicine, 20, 211-218. https://doi.org/10.3892/etm.2020.8721
MLA
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., Chen, L."Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation". Experimental and Therapeutic Medicine 20.1 (2020): 211-218.
Chicago
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., Chen, L."Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation". Experimental and Therapeutic Medicine 20, no. 1 (2020): 211-218. https://doi.org/10.3892/etm.2020.8721
Copy and paste a formatted citation
x
Spandidos Publications style
Liang H, Cui Y, Bu H, Liu H, Yan P, Cui L and Chen L: Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation. Exp Ther Med 20: 211-218, 2020.
APA
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., & Chen, L. (2020). Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation. Experimental and Therapeutic Medicine, 20, 211-218. https://doi.org/10.3892/etm.2020.8721
MLA
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., Chen, L."Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation". Experimental and Therapeutic Medicine 20.1 (2020): 211-218.
Chicago
Liang, H., Cui, Y., Bu, H., Liu, H., Yan, P., Cui, L., Chen, L."Value of S100A12 in predicting in‑stent restenosis in patients with coronary drug‑eluting stent implantation". Experimental and Therapeutic Medicine 20, no. 1 (2020): 211-218. https://doi.org/10.3892/etm.2020.8721
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