Open Access

Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial

  • Authors:
    • Gehui Li
    • Yuci Xiao
    • Xiaofei Qi
    • Hao Wang
    • Xiaoguang Wang
    • Jing Sun
    • Yong Li
    • Yuantao Li
  • View Affiliations

  • Published online on: May 7, 2020     https://doi.org/10.3892/etm.2020.8730
  • Pages: 454-460
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2‑agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine for epidural labor analgesia was investigated. A total of 108 parturient women receiving labor epidural analgesia were randomly divided into three groups: i) Group RD received 0.1% ropivacaine + 0.5 µg/ml Dex; ii) Group RS received 0.1% ropivacaine + 0.5 µg/ml sufentanil; and iv) Group RDS received 0.1% ropivacaine + 0.25 µg/ml Dex + 0.25 µg/ml sufentanil. Patients received a 10 ml loading dose followed by a maintenance by patient controlled epidural analgesia. The visual analog scale scores, onset time, local anesthetic requirements, motor blockage and adverse effects were recorded. Group RDS displayed an improved labor analgesia effect compared with Groups RD and RS. Group RDS displayed a shorter onset time compared with Groups RD and RS, and a reduced local anesthetic requirement compared with Group RS. The motor blockage in Groups RDS and RS was significantly lower compared with Group RD, and the incidence of pruritus in Groups RDS and RD was lower compared with Group RS. In conclusion, the combined use of 0.25 µg/ml Dex and 0.25 µg/ml sufentanil as adjuvants to 0.1% ropivacaine for epidural labor analgesia displayed an improved analgesia effect compared with the use of either 0.5 µg/ml sufentanil or 0.5 µg/ml Dex alone. The present study was registered with the Chinese Clinical Trial Registry Center on 23 February, 2018 (registration no. ChiCTR‑IOR‑1800014943).
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July-2020
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Spandidos Publications style
Li G, Xiao Y, Qi X, Wang H, Wang X, Sun J, Li Y and Li Y: Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Exp Ther Med 20: 454-460, 2020
APA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J. ... Li, Y. (2020). Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Experimental and Therapeutic Medicine, 20, 454-460. https://doi.org/10.3892/etm.2020.8730
MLA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20.1 (2020): 454-460.
Chicago
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20, no. 1 (2020): 454-460. https://doi.org/10.3892/etm.2020.8730