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Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial

  • Authors:
    • Gehui Li
    • Yuci Xiao
    • Xiaofei Qi
    • Hao Wang
    • Xiaoguang Wang
    • Jing Sun
    • Yong Li
    • Yuantao Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518028, P.R. China, Department of Food Safety, Market Supervision Administration of Shenzhen Municipality, Shenzhen, Guangdong 518040, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 454-460
    |
    Published online on: May 7, 2020
       https://doi.org/10.3892/etm.2020.8730
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Abstract

Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2‑agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine for epidural labor analgesia was investigated. A total of 108 parturient women receiving labor epidural analgesia were randomly divided into three groups: i) Group RD received 0.1% ropivacaine + 0.5 µg/ml Dex; ii) Group RS received 0.1% ropivacaine + 0.5 µg/ml sufentanil; and iv) Group RDS received 0.1% ropivacaine + 0.25 µg/ml Dex + 0.25 µg/ml sufentanil. Patients received a 10 ml loading dose followed by a maintenance by patient controlled epidural analgesia. The visual analog scale scores, onset time, local anesthetic requirements, motor blockage and adverse effects were recorded. Group RDS displayed an improved labor analgesia effect compared with Groups RD and RS. Group RDS displayed a shorter onset time compared with Groups RD and RS, and a reduced local anesthetic requirement compared with Group RS. The motor blockage in Groups RDS and RS was significantly lower compared with Group RD, and the incidence of pruritus in Groups RDS and RD was lower compared with Group RS. In conclusion, the combined use of 0.25 µg/ml Dex and 0.25 µg/ml sufentanil as adjuvants to 0.1% ropivacaine for epidural labor analgesia displayed an improved analgesia effect compared with the use of either 0.5 µg/ml sufentanil or 0.5 µg/ml Dex alone. The present study was registered with the Chinese Clinical Trial Registry Center on 23 February, 2018 (registration no. ChiCTR‑IOR‑1800014943).
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Copy and paste a formatted citation
Spandidos Publications style
Li G, Xiao Y, Qi X, Wang H, Wang X, Sun J, Li Y and Li Y: Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Exp Ther Med 20: 454-460, 2020.
APA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J. ... Li, Y. (2020). Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Experimental and Therapeutic Medicine, 20, 454-460. https://doi.org/10.3892/etm.2020.8730
MLA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20.1 (2020): 454-460.
Chicago
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20, no. 1 (2020): 454-460. https://doi.org/10.3892/etm.2020.8730
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Xiao Y, Qi X, Wang H, Wang X, Sun J, Li Y and Li Y: Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Exp Ther Med 20: 454-460, 2020.
APA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J. ... Li, Y. (2020). Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. Experimental and Therapeutic Medicine, 20, 454-460. https://doi.org/10.3892/etm.2020.8730
MLA
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20.1 (2020): 454-460.
Chicago
Li, G., Xiao, Y., Qi, X., Wang, H., Wang, X., Sun, J., Li, Y., Li, Y."Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial". Experimental and Therapeutic Medicine 20, no. 1 (2020): 454-460. https://doi.org/10.3892/etm.2020.8730
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