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Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy

  • Authors:
    • Shu‑Hong Guan
    • Ming Zhang
    • Su‑Juan Zhang
    • Qiu‑Di Zhang
    • Qian‑Qian Xu
    • Jun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Changzhou No. 1 Hospital, Changzhou, Jiangsu 213000, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 810-817
    |
    Published online on: May 12, 2020
       https://doi.org/10.3892/etm.2020.8734
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Abstract

The aim of the present study was to determine the indications for radial endobronchial ultrasound‑guided transbronchial lung biopsy (rEBUS‑D‑TBLB) for the diagnosis of peripheral pulmonary lesions (PPL) located at the bronchopulmonary segments and subsegments. Data collected from 774 patients who underwent rEBUS‑D‑TBLB for suspected PPL, including clinical information, distribution of lesions, diagnostic spectrum and diagnostic rate, were collected and retrospectively reviewed. Additionally, the Wilcoxon signed‑rank test was performed to analyze the diagnostic yield of lesions in bronchopulmonary subsegments under the lesion diameter limit of 3 cm. In total, 802 lesions were found in 774 patients. The diagnostic yield of rEBUS‑D‑TBLB for all lesions was 67.18%. Overall, 362 cases of malignant disease and 158 cases of benign disease were diagnosed, with sensitivities of 70.98 and 79.00% respectively. Lesions were distributed throughout the 18 bronchopulmonary segments of the lungs. The bronchopulmonary segments with >5% of the majority of the discovered lesions were LB1+2, LB3, LB6, LB10, RB1‑4 and RB9. The diagnostic yield of rEBUS‑D‑TBLB was found to be >65% for lesions located at LB3, RB1‑3 and RB9. Further rEBUS‑D‑TBLB examinations of the LB1+2a, LB6a and RB4b segments produced diagnostic yields of 81.25, 66.67 and 71.43% respectively. Finally, at segment RB4a, rEBUS‑D‑TBLB examination was more effective for lesions with diameters >3 cm compared with lesions with diameters <3 cm. The diagnostic yields for PPL distributed at LB1+2a, LB3, LB6a, RB1‑3, RB4a (diameter >3 cm), RB4b, and RB9 using rEBUS‑D‑TBLB were higher compared with for other segments, providing a theoretical basis for the clinical application of rEBUS‑D‑TBLB for the diagnosis of PPL in patients.
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Copy and paste a formatted citation
Spandidos Publications style
Guan SH, Zhang M, Zhang SJ, Zhang QD, Xu QQ and Zhou J: Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy. Exp Ther Med 20: 810-817, 2020.
APA
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., & Zhou, J. (2020). Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy. Experimental and Therapeutic Medicine, 20, 810-817. https://doi.org/10.3892/etm.2020.8734
MLA
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., Zhou, J."Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy". Experimental and Therapeutic Medicine 20.2 (2020): 810-817.
Chicago
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., Zhou, J."Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy". Experimental and Therapeutic Medicine 20, no. 2 (2020): 810-817. https://doi.org/10.3892/etm.2020.8734
Copy and paste a formatted citation
x
Spandidos Publications style
Guan SH, Zhang M, Zhang SJ, Zhang QD, Xu QQ and Zhou J: Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy. Exp Ther Med 20: 810-817, 2020.
APA
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., & Zhou, J. (2020). Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy. Experimental and Therapeutic Medicine, 20, 810-817. https://doi.org/10.3892/etm.2020.8734
MLA
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., Zhou, J."Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy". Experimental and Therapeutic Medicine 20.2 (2020): 810-817.
Chicago
Guan, S., Zhang, M., Zhang, S., Zhang, Q., Xu, Q., Zhou, J."Analysis of indications for pulmonary peripheral lesions diagnosed using radial endobronchial ultrasound‑guided transbronchial lung biopsy". Experimental and Therapeutic Medicine 20, no. 2 (2020): 810-817. https://doi.org/10.3892/etm.2020.8734
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