Open Access

Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells

  • Authors:
    • Dongmei Wu
    • Zihui Zheng
    • Shaohua Fan
    • Xin Wen
    • Xinrui Han
    • Shan Wang
    • Yongjian Wang
    • Zifeng Zhang
    • Qun Shan
    • Mengqiu Li
    • Bin Hu
    • Yuanlin Zheng
    • Jun Lu
  • View Affiliations

  • Published online on: May 13, 2020     https://doi.org/10.3892/etm.2020.8742
  • Pages: 854-859
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Epilepsy is a prevalent neurological disorder and it is a significant health risk, affecting >50 million people worldwide. The development of novel and appropriate strategies is required for ameliorating the progression and/or limiting the detrimental consequences of epilepsy. In the current study, kainic acid (KA), a neurotoxin, was used to induce seizures in mice. The flavonoid quercetin has recently been reported to have neuroprotective effects. Therefore, the effects of quercetin on KA‑induced epilepsy and the potential underlying molecular mechanisms were examined. It was noted that quercetin attenuated the KA‑induced seizure score and proinflammatory cytokine production, including tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β), and activation of nuclear factor κB (NF‑κB) in mice. Quercetin attenuated KA‑induced proinflammatory cytokine (TNF‑α and IL‑1β) release from microglia cells, as well as activation of NF‑κB and ionized calcium binding adapter molecule 1 in microglia cells. Therefore, quercetin inhibited KA‑induced epilepsy by microglia cell inactivation and the production of NF‑κB, TNF‑α and IL‑1β.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Wu, D., Zheng, Z., Fan, S., Wen, X., Han, X., Wang, S. ... Lu, J. (2020). Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells. Experimental and Therapeutic Medicine, 20, 854-859. https://doi.org/10.3892/etm.2020.8742
MLA
Wu, D., Zheng, Z., Fan, S., Wen, X., Han, X., Wang, S., Wang, Y., Zhang, Z., Shan, Q., Li, M., Hu, B., Zheng, Y., Lu, J."Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells". Experimental and Therapeutic Medicine 20.2 (2020): 854-859.
Chicago
Wu, D., Zheng, Z., Fan, S., Wen, X., Han, X., Wang, S., Wang, Y., Zhang, Z., Shan, Q., Li, M., Hu, B., Zheng, Y., Lu, J."Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells". Experimental and Therapeutic Medicine 20, no. 2 (2020): 854-859. https://doi.org/10.3892/etm.2020.8742