|
1
|
Wang YC, McPherson K, Marsh T, Gortmaker
SL and Brown M: Health and economic burden of the projected obesity
trends in the USA and the UK. Lancet. 378:815–825. 2011.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Scheen AJ and Van Gaal LF: Combating the
dual burden: Therapeutic targeting of common pathways in obesity
and type 2 diabetes. Lancet Diabetes Endocrinol. 2:911–922.
2014.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Tiwari S and Ndisang JF: The role of
obesity in cardiomyopathy and nephropathy. Curr Pharm Des.
20:1409–1417. 2014.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Kenchaiah S, Evans JC, Levy D, Wilson PW,
Benjamin EJ, Larson MG, Kannel WB and Vasan RS: Obesity and the
risk of heart failure. New Engl J Med. 347:305–313. 2002.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Cohn JN, Ferrari R and Sharpe N: Cardiac
remodeling-concepts and clinical implications: A consensus paper
from an international forum on cardiac remodeling. Behalf of an
international forum on cardiac remodeling. J Am Coll Cardiol.
35:569–582. 2000.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Rhee SG and Bae SH: The antioxidant
function of sestrins is mediated by promotion of autophagic
degradation of Keap1 and Nrf2 activation and by inhibition of
mTORC1. Free Radic Biol Med. 88:205–211. 2015.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Bae SH, Sung SH, Oh SY, Lim JM, Lee SK,
Park YN, Lee HE, Kang D and Rhee SG: Sestrins activate Nrf2 by
promoting p62-dependent autophagic degradation of Keap1 and prevent
oxidative liver damage. Cell Metab. 17:73–84. 2013.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Suzuki T, Motohashi H and Yamamoto M:
Toward clinical application of the Keap1-Nrf2 pathway. Trends
Pharmacol Sci. 34:340–346. 2013.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Foretz M, Guigas B, Bertrand L, Pollak M
and Viollet B: Metformin: From mechanisms of action to therapies.
Cell Metab. 20:953–966. 2014.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Calvert JW, Gundewar S, Jha S, Greer JJ,
Bestermann WH, Tian R and Lefer DJ: Acute metformin therapy confers
cardioprotection against myocardial infarction via
AMPK-eNOS-mediated signaling. Diabetes. 57:696–705. 2008.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Soraya H, Khorrami A and Garjani A,
Maleki-Dizaji N and Garjani A: Acute treatment with metformin
improves cardiac function following isoproterenol induced
myocardial infarction in rats. Pharmacol Rep. 64:1476–1484.
2012.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Burlá AK, Lobato NS, Fortes ZB, Oigman W
and Neves MF: Cardiac fibrosis and vascular remodeling are
attenuated by metformin in obese rats. Int J Cardiol. 165:483–487.
2011.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Fu YN, Xiao H, Ma XW, Jiang SY, Xu M and
Zhang YY: Metformin attenuates pressure overload-induced cardiac
hypertrophy via AMPK activation. Acta Pharmacol Sin. 32:879–887.
2011.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Cha HN, Choi JH, Kim YW, Kim JY, Ahn MW
and Park SY: Metformin inhibits isoproterenol-induced cardiac
hypertrophy in mice. Korean J Physiol Pharmacol. 14:377–384.
2010.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Clark JD, Gebhart GF, Gonder JC, Keeling
ME and Kohn DF: Special Report: The 1996 guide for the care and use
of laboratory animals. ILAR J. 38:41–48. 1997.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Canis R, Demirkok SS, Osar Z, Balci H and
Can G: Effects of inhaled budesonide on insulin sensitivity in
nondiabetic patients with asthma and chronic obstructive pulmonary
disease. Adv Ther. 24:560–570. 2007.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin
MW and Liu H: Pentamethylquercetin induces adipose browning and
exerts beneficial effects in 3T3-L1 adipocytes and high-fat
diet-fed mice. Sci Rep. 7(1123)2017.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Matthews DR, Hosker JP, Rudenski AS,
Naylor BA, Treacher DF and Turner RC: Homeostasis model assessment:
Insulin resistance and beta-cell function from fasting plasma
glucose and insulin concentrations in man. Diabetologia.
28:412–419. 1985.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Simon J, Nemeth E, Nemes A, Husveth-Toth
M, Radovits T, Foldes G, Kiss L, Bagyura Z, Skopal J, Merkely B and
Gara E: Circulating relaxin-1 level is a surrogate marker of
myocardial fibrosis in HFrEF. Front Physiol. 10(690)2019.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) methods. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Ng M, Fleming T, Robinson M, Thomson B,
Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF,
et al: Global, regional, and national prevalence of overweight and
obesity in children and adults during 1980-2013: A systematic
analysis for the Global Burden of Disease Study 2013. Lancet.
384:766–781. 2014.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Brady TM: The role of obesity in the
development of left ventricular hypertrophy among children and
adolescents. Curr Hypertens Rep. 18(3)2016.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Zhang Y, Fang X, Dai M, Cao Q, Tan T, He
W, Huang Y, Chu L and Bao M: Cardiac-specific down-regulation of
carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac
remodeling in obese mice. Obesity (Silver Spring). 24:2533–2543.
2016.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Sasaki H, Asanuma H, Fujita M, Takahama H,
Wakeno M, Ito S, Ogai A, Asakura M, Kim J, Minamino T, et al:
Metformin prevents progression of heart failure in dogs: Role of
AMP-activated protein kinase. Circulation. 119:2568–2577.
2009.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Xie Z, Lau K, Eby B, Lozano P, He C,
Pennington B, Li H, Rathi S, Dong Y, Tian R, et al: Improvement of
cardiac functions by chronic metformin treatment is associated with
enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes.
60:1770–1778. 2011.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Daugan M, Dufaÿ Wojcicki A, d Hayer B and
Boudy V: Metformin: An anti-diabetic drug to fight cancer.
Pharmacol Res. 113:675–685. 2016.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Barzilai N, Crandall JP, Kritchevsky SB
and Espeland MA: Metformin as a tool to target aging. Cell Metab.
23:1060–1065. 2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Luo T, Nocon A, Fry J, Sherban A, Rui X,
Jiang B, Xu XJ, Han J, Yan Y, Yang Q, et al: AMPK Activation by
metformin suppresses abnormal extracellular matrix remodeling in
adipose tissue and ameliorates insulin resistance in obesity.
Diabetes. 65:2295–2310. 2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M,
Shen Q, Zhu Y and Zhang Y: Metformin attenuates cardiac fibrosis by
inhibiting the TGFbeta1-Smad3 signalling pathway. Cardiovasc Res.
87:504–513. 2010.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Batchuluun B, Inoguchi T, Sonoda N, Sasaki
S, Inoue T, Fujimura Y, Miura D and Takayanagi R: Metformin and
liraglutide ameliorate high glucose-induced oxidative stress via
inhibition of PKC-NAD(P)H oxidase pathway in human aortic
endothelial cells. Atherosclerosis. 232:156–164. 2014.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Kawabata H and Ishikawa K:
Cardioprotection by metformin is abolished by a nitric oxide
synthase inhibitor in ischemic rabbit hearts. Hypertens Res.
26:107–110. 2003.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Ashabi G, Khalaj L, Khodagholi F,
Goudarzvand M and Sarkaki A: Pre-treatment with metformin activates
Nrf2 antioxidant pathways and inhibits inflammatory responses
through induction of AMPK after transient global cerebral ischemia.
Metab Brain Dis. 30:747–754. 2015.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Li J, Ichikawa T, Jin Y, Hofseth LJ,
Nagarkatti P, Nagarkatti M, Windust A and Cui T: An essential role
of Nrf2 in American ginseng-mediated anti-oxidative actions in
cardiomyocytes. J Ethnopharmacol. 130:222–230. 2010.PubMed/NCBI View Article : Google Scholar
|
