Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the
JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531

Jiang,Chunmao; Yang,Haifeng; Chen,Xiaolan; Qiu,Shulei; Wu,Caihong; Zhang,Bin; Jin,Liqin

doi:10.3892/etm.2020.8766

Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway

Corrigendum in: /10.3892/etm.2024.12531

Authors:
- Chunmao Jiang
- Haifeng Yang
- Xiaolan Chen
- Shulei Qiu
- Caihong Wu
- Bin Zhang
- Liqin Jin
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Affiliations: School of Veterinary Medicine, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China, School of Animal Pharmaceutical Sciences, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China, School of Pet Science and Technology, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China
Published online on: May 18, 2020 https://doi.org/10.3892/etm.2020.8766
Pages: 1137-1144

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Abstract

Accumulating evidence demonstrates that Macleaya cordata extract exerts antiviral and anti‑inflammatory effects in various diseases. The present study aimed to investigate the potential effects of M. cordata on rotavirus SA11‑induced diarrhea in mice. Diarrhea severity, levels of inflammatory cytokines, histological changes in the small intestine and the underlying mechanisms were evaluated in rotavirus‑stimulated mice treated with 1, 2 and 4 mg/kg/day M. cordata or 4 mg/kg/day ribavirin (positive control). M. cordata treatment effectively ameliorated rotavirus‑induced diarrhea in a dose‑dependent manner by decreasing viral RNA levels. In addition, M. cordata reduced the release of pro‑inflammatory cytokines including migration inhibitory factor, interleukin (IL)‑8, IL‑β, interferon‑γ and tumor necrosis factor‑α, and elevated the secretion of the anti‑inflammatory cytokine IL‑10 following rotavirus infection. M. cordata inhibited intestinal epithelial cell apoptosis and improved intestinal inflammation after rotavirus infection. The study also revealed that M. cordata exerted antiviral and anti‑inflammatory effects on rotavirus‑induced diarrhea by suppressing the Janus kinase 2 (JAK2)/STAT3 pathway, as reflected by decreased protein expression of phosphorylated (p)‑JAK2 and p‑STAT3. Overall, M. cordata effectively inhibited the inflammation caused by rotavirus, which was closely associated with the suppression of JAK2/STAT3 phosphorylation. These data suggested that M. cordata may be applied as a treatment for rotavirus‑induced diarrhea.

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