Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway

Corrigendum in: /10.3892/etm.2024.12531
  • Authors:
    • Chunmao Jiang
    • Haifeng Yang
    • Xiaolan Chen
    • Shulei Qiu
    • Caihong Wu
    • Bin Zhang
    • Liqin Jin
  • View Affiliations / Copyright

    Affiliations: School of Veterinary Medicine, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China, School of Animal Pharmaceutical Sciences, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China, School of Pet Science and Technology, Jiangsu Agri‑animal Husbandry Vocational College, Taizhou, Jiangsu 225300, P.R. China
  • Pages: 1137-1144
    |
    Published online on: May 18, 2020
       https://doi.org/10.3892/etm.2020.8766
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Accumulating evidence demonstrates that Macleaya cordata extract exerts antiviral and anti‑inflammatory effects in various diseases. The present study aimed to investigate the potential effects of M. cordata on rotavirus SA11‑induced diarrhea in mice. Diarrhea severity, levels of inflammatory cytokines, histological changes in the small intestine and the underlying mechanisms were evaluated in rotavirus‑stimulated mice treated with 1, 2 and 4 mg/kg/day M. cordata or 4 mg/kg/day ribavirin (positive control). M. cordata treatment effectively ameliorated rotavirus‑induced diarrhea in a dose‑dependent manner by decreasing viral RNA levels. In addition, M. cordata reduced the release of pro‑inflammatory cytokines including migration inhibitory factor, interleukin (IL)‑8, IL‑β, interferon‑γ and tumor necrosis factor‑α, and elevated the secretion of the anti‑inflammatory cytokine IL‑10 following rotavirus infection. M. cordata inhibited intestinal epithelial cell apoptosis and improved intestinal inflammation after rotavirus infection. The study also revealed that M. cordata exerted antiviral and anti‑inflammatory effects on rotavirus‑induced diarrhea by suppressing the Janus kinase 2 (JAK2)/STAT3 pathway, as reflected by decreased protein expression of phosphorylated (p)‑JAK2 and p‑STAT3. Overall, M. cordata effectively inhibited the inflammation caused by rotavirus, which was closely associated with the suppression of JAK2/STAT3 phosphorylation. These data suggested that M. cordata may be applied as a treatment for rotavirus‑induced diarrhea.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Boshuizen JA, Reimerink JH, Korteland-van Male AM, van Ham VJ, Koopmans MP, Büller HA, Dekker J and Einerhand AW: Changes in small intestinal homeostasis, morphology, and gene expression during rotavirus infection of infant mice. J Virol. 77:13005–13016. 2003.PubMed/NCBI View Article : Google Scholar

2 

Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J and Parashar UD: WHO-coordinated Global Rotavirus Surveillance Network: 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programs: A systematic review and meta-analysis. Lancet Infect Dis. 12:136–141. 2012.PubMed/NCBI View Article : Google Scholar

3 

Pesavento JB, Crawford SE, Estes MK and Prasad BV: Rotavirus proteins: Structure and assembly. Curr Top Microbiol Immunol. 309:189–219. 2006.PubMed/NCBI View Article : Google Scholar

4 

Kawahara T, Tomono T, Hamauzu Y, Tanaka K and Yasui H: Inhibitory effect of a hot-water extract of leaves of Japanese big-leaf magnolia (magnolia obovata) on rotavirus-induced diarrhea in mouse pups. Evid Based Complement Alternat Med. 2014(365831)2014.PubMed/NCBI View Article : Google Scholar

5 

Anderson EJ: Rotavirus vaccines: Viral shedding and risk of transmission. Lancet Infect Dis. 8:642–649. 2008.PubMed/NCBI View Article : Google Scholar

6 

Lepage P and Vergison A: Prevention of childhood rotavirus disease through the use of Rotarix and RotaTeq vaccines. Expert Opin Biol Ther. 7:1881–1892. 2007.PubMed/NCBI View Article : Google Scholar

7 

Liu M, Lin YL, Chen XR, Liao CC and Poo WK: In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in normal and cancerous human lung cells. Exp Toxicol Pathol. 65:775–787. 2013.PubMed/NCBI View Article : Google Scholar

8 

Lin L, Liu YC, Huang JL, Liu XB, Qing ZX, Zeng JG and Liu ZY: Medicinal plants of the genus Macleaya (Macleaya cordata, Macleaya microcarpa): A review of their phytochemistry, pharmacology, and toxicology. Phytother Res. 32:19–48. 2018.PubMed/NCBI View Article : Google Scholar

9 

Ke W, Lin X, Yu Z, Sun Q and Zhang Q: Molluscicidal activity and physiological toxicity of Macleaya cordata alkaloids components on snail oncomelania hupensis. Pestic Biochem Physiol. 143:111–115. 2017.PubMed/NCBI View Article : Google Scholar

10 

Arnold M, Patton JT and McDonald SM: Culturing, storage, and quantification of rotaviruses. Curr Protoc Microbiol. 15(Unit 15C 3)2009.PubMed/NCBI View Article : Google Scholar

11 

Tian Z, Shen Z, He H, Zhang J, Li J and Wu Y: Antiviral effects of cyclosporin a in neonatal mice with rotavirus-induced diarrhea. J Pediatr Gastroenterol Nutr. 60:11–17. 2015.PubMed/NCBI View Article : Google Scholar

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

13 

Shen Z, He H, Wu Y and Li J: Cyclosporin a inhibits rotavirus replication and restores interferon-beta signaling pathway in vitro and in vivo. PLoS One. 8(e71815)2013.PubMed/NCBI View Article : Google Scholar

14 

Liu G, Guan G, Fang J, Martínez Y, Chen S, Bin P, Duraipandiyan V, Gong T, Tossou MC, Al-Dhabi NA and Yin Y: Macleaya cordata extract decreased diarrhea score and enhanced intestinal barrier function in growing piglets. Biomed Res Int. 2016(1069585)2016.PubMed/NCBI View Article : Google Scholar

15 

Dung TT, Phat VV, Nga TV, My PV, Duy PT, Campbell JI, Thuy CT, Hoang NV, Van Minh P, Le Phuc H, et al: The validation and utility of a quantitative one-step multiplex RT real-time PCR targeting rotavirus A and norovirus. J Virol Methods. 187:138–143. 2013.PubMed/NCBI View Article : Google Scholar

16 

Alfajaro MM, Kim HJ, Park JG, Ryu EH, Kim JY, Jeong YJ, Kim DS, Hosmillo M, Son KY, Lee JH, et al: Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virol J. 9(310)2012.

17 

Ciarlet M, Conner ME, Finegold MJ and Estes MK: Group A rotavirus infection and age-dependent diarrheal disease in rats: A new animal model to study the pathophysiology of rotavirus infection. J Virol. 76:41–57. 2002.PubMed/NCBI View Article : Google Scholar

18 

Guerin-Danan C, Meslin JC, Lambre F, Charpilienne A, Serezat M, Bouley C, Cohen J and Andrieux C: Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea. J Virol. 72:9298–9302. 1998.PubMed/NCBI

19 

Ward RL: Possible mechanisms of protection elicited by candidate rotavirus vaccines as determined with the adult mouse model. Viral Immunol. 16:17–24. 2003.PubMed/NCBI View Article : Google Scholar

20 

Lei Q, Liu H, Peng Y and Xiao P: In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui). Chin Med. 10(37)2015.PubMed/NCBI View Article : Google Scholar

21 

Freitas K, Carroll FI and Damaj MI: The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J Pharmacol Exp Ther. 344:264–275. 2013.PubMed/NCBI View Article : Google Scholar

22 

Jiang B, Snipes-Magaldi L, Dennehy P, Keyserling H, Holman RC, Bresee J, Gentsch J and Glass RI: Cytokines as mediators for or effectors against rotavirus disease in children. Clin Diagn Lab Immunol. 10:995–1001. 2003.PubMed/NCBI View Article : Google Scholar

23 

Khadem A, Soler L, Everaert N and Niewold TA: Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties. Br J Nutr. 112:1110–1118. 2014.PubMed/NCBI View Article : Google Scholar

24 

Vrba J, Orolinova E and Ulrichova J: Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264. .7 cells. Fitoterapia. 83:329–335. 2012.PubMed/NCBI View Article : Google Scholar

25 

Fagone P, Patti F, Mangano K, Mammana S, Coco M, Touil-Boukoffa C, Chikovani T, Di Marco R and Nicoletti F: Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis. J Neuroimmunol. 261:82–86. 2013.PubMed/NCBI View Article : Google Scholar

26 

Ronco C, Ronco F and Mccullough PA: A call to action to develop integrated curricula in cardiorenal medicine. Rev Cardiovasc Med. 18:93–99. 2017.PubMed/NCBI View Article : Google Scholar

27 

Jin J, Liu Y, Huang L and Tan H: Advances in epigenetic regulation of vascular aging. Rev Cardiovasc Med. 20:19–25. 2019.PubMed/NCBI View Article : Google Scholar

28 

Yilmaz E, Coskun EI, Gul M, Sahin N, Tuncay G and Simsek Y: Nuclear factor-kappa β pathway and endometrial cancer: A pilot study. Eur J Gynaecol Oncol. 38:536–540. 2017.PubMed/NCBI View Article : Google Scholar

29 

Tian JS, Zhai QJ, Zhao Y, Chen R and Zhao LD: 2-(2-benzofuranyl)-2-imidazoline (2-BFI) improved the impairments in AD rat models by inhibiting oxidative stress, inflammation and apoptosis. J Integr Neurosci. 16:385–400. 2017.PubMed/NCBI View Article : Google Scholar

30 

Fagone P, Mazzon E, Cavalli E, Bramanti A, Petralia MC, Mangano K, Al-Abed Y, Bramati P and Nicoletti F: Contribution of the macrophage migration inhibitory factor superfamily of cytokines in the pathogenesis of preclinical and human multiple sclerosis: In silico and in vivo evidences. J Neuroimmunol. 322:46–56. 2018.PubMed/NCBI View Article : Google Scholar

31 

Presti M, Mazzon E, Basile MS, Petralia MC, Bramanti A, Colletti G, Bramanti P, Nicoletti F and Fagone P: Overexpression of macrophage migration inhibitory factor and functionally-related genes, D-DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma. Oncol Lett. 16:2881–2886. 2018.PubMed/NCBI View Article : Google Scholar

32 

Lang T, Lee JPW, Elgass K, Pinar AA, Tate MD, Aitken EH, Fan H, Creed SJ, Deen NS, Traore DAK, et al: Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nat Commun. 9(2223)2018.PubMed/NCBI View Article : Google Scholar

33 

Gandhi GR, Santos VS, Denadai M, da Silva Calisto VK, de Souza Siqueira Quintans J, de Oliveira E Silva AM, de Souza Araújo AA, Narain N, Cuevas LE, Júnior LJQ and Gurgel RQ: Cytokines in the management of rotavirus infection: A systematic review of in vivo studies. Cytokine. 96:152–160. 2017.PubMed/NCBI View Article : Google Scholar

34 

Feng N, Kim B, Fenaux M, Nguyen H, Vo P, Omary MB and Greenberg HB: Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol. 82:7578–7590. 2008.PubMed/NCBI View Article : Google Scholar

35 

Liu M, Zhao G, Cao S, Zhang Y, Li X and Lin X: Development of certain protein kinase inhibitors with the components from traditional chinese medicine. Front Pharmacol. 7(523)2017.PubMed/NCBI View Article : Google Scholar

36 

Mammana S, Bramanti P, Mazzon E, Cavalli E, Basile MS, Fagone P, Petralia MC, McCubrey JA, Nicoletti F and Mangano K: Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis. Oncotarget. 9:8263–8277. 2018.PubMed/NCBI View Article : Google Scholar

37 

Horie R, Nakamura O, Yamagami Y, Mori M, Nishimura H, Fukuoka N and Yamamoto T: Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells. Int J Oncol. 48:37–44. 2016.PubMed/NCBI View Article : Google Scholar

38 

Yin Y, Dang W, Zhou X, Xu L, Wang W, Cao W, Chen S, Su J, Cai X, Xiao S, et al: PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target. Virulence. 9:83–98. 2018.PubMed/NCBI View Article : Google Scholar

39 

Raible DJ, Frey LC and Brooks-Kayal AR: Effects of JAK2-STAT3 signaling after cerebral insults. JAKSTAT. 3(e29510)2014.PubMed/NCBI View Article : Google Scholar

40 

Sansone P and Bromberg J: Targeting the interleukin6/Jak/stat pathway in human malignancies. J Clin Oncol. 30:1005–1014. 2012.PubMed/NCBI View Article : Google Scholar

41 

Cui J, Zhang F, Cao W, Wang Y, Liu J, Liu X, Chen T, Li L, Tian J and Yu B: Erythropoietin alleviates hyperglycaemia-associated inflammation by regulating macrophage polarization via the JAK2/STAT3 signalling pathway. Mol Immunol. 101:221–228. 2018.PubMed/NCBI View Article : Google Scholar

42 

Yang X, Jia J, Yu Z, Duanmu Z, He H, Chen S and Qu C: Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit. BMC Cardiovasc Disord. 20(133)2020.PubMed/NCBI View Article : Google Scholar

43 

Li CH, Xu LL, Zhao JX, Sun L, Yao ZQ, Deng XL, Liu R, Yang L, Xing R and Liu XY: CXCL16 upregulates RANKL expression in rheumatoid arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway. Inflamm Res. 65:193–202. 2016.PubMed/NCBI View Article : Google Scholar

44 

Liu Y, Holdbrooks AT, De Sarno P, Rowse AL, Yanagisawa LL, McFarland BC, Harrington LE, Raman C, Sabbaj S, Benveniste EN and Qin H: Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol. 192:59–72. 2014.PubMed/NCBI View Article : Google Scholar

45 

Villarino AV, Kanno Y, Ferdinand JR and O'Shea JJ: Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol. 194:21–27. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang C, Yang H, Chen X, Qiu S, Wu C, Zhang B and Jin L: Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Exp Ther Med 20: 1137-1144, 2020.
APA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., & Jin, L. (2020). Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Experimental and Therapeutic Medicine, 20, 1137-1144. https://doi.org/10.3892/etm.2020.8766
MLA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20.2 (2020): 1137-1144.
Chicago
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1137-1144. https://doi.org/10.3892/etm.2020.8766
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang C, Yang H, Chen X, Qiu S, Wu C, Zhang B and Jin L: Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Exp Ther Med 20: 1137-1144, 2020.
APA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., & Jin, L. (2020). Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Experimental and Therapeutic Medicine, 20, 1137-1144. https://doi.org/10.3892/etm.2020.8766
MLA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20.2 (2020): 1137-1144.
Chicago
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1137-1144. https://doi.org/10.3892/etm.2020.8766
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team